Clinical trials: Early Phase 1, open to volunteers
Autoimmune Diseases
CD19 CAR-T in the Treatment of Relapsed/Refractory Autoimmune Diseases
Autoimmune diseases such as systemic lupus erythematosus (SLE), diffuse cutaneous systemic sclerosis (dcSSc), antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (AAV), idiopathic inflammatory myopathy (IIM), and…
- Trial name
- NCT06680388
- Testing
- Drug：CD19 CAR-T
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Tauopathies
Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A
The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 18F-JSS20-183A. The goal of this radiotracer is to quantify 4Repeat Tau (4Rtau) protein that is abnormally deposited in the brain…
- Trial name
- NCT06932809
- Testing
- 18F-JSS20-183A PET, Brain MRI, Amyloid PET
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Pennsylvania
IgG4 Related Disease
An Exploratory Clinical Study on the Safety and Efficacy of CD19/BCMA CAR-NK in the Treatment of Relapsed and Refractory IgG4-related Disease
A single arm, open-label pilot study is designed to determine the safety and effectiveness of CD19/BCMA CAR NK cells (KN5601) in patients with IgG4 related diseases.
- Trial name
- NCT07298590
- Testing
- CD19/BCMA CAR NK
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital
Cervical Spinal Cord Injury
Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System
Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system.
- Trial name
- NCT07299734
- Testing
- AR + FES
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY)
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
This study aims to understand the heart and blood sugar health benefits of using an adjunctive therapy to lower high insulin levels in people with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY), MODY2 Diabetes, Healthy Volunteer
- Trial name
- ACT T1D (NCT06609356)
- Testing
- Study Visit 1, Study Visit 2, Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Advanced Malignant Solid Tumor of Digestive System
A Clinical Study on Evaluating Intravenous Administration of IDOV-SAFE
Subjects were Chinese patients with histologically or cytologically confirmed advanced malignant solid tumors (mainly focused on MSS type colon and rectal cancer) who had failed standard systemic therapy and were inoperable.
- Trial name
- NCT06380309
- Testing
- IIA1：1E9 PFU of oncolytic virus, sequentially combination, IIA2：3E9 PFU of oncolytic virus, sequentially combination, IIC1：1E9 PFU of oncolytic virus, early combination
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Peking University
Type 2 Diabetes
Precision Dosing of Metformin in Youth With T2D
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
- Trial name
- PRECISE_T2D (NCT06120881)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glioblastoma Multiforme
Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme
This is a single-arm pilot study that will recruit 12 patients with newly diagnosed Glioblastoma, a malignant brain tumor with a poor prognosis.
- Trial name
- NCT05423210
- Testing
- Atezolizumab + FSRT radiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Chronic Non-specific Low Back Pain
Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP)
Chronic non-specific low back pain (CNSLBP) is among the most prevalent causes of disability on the planet, which often proves to be refractory to conventional pharmacological, interventional, and rehabilitation approaches.
- Trial name
- NCT07296653
- Testing
- Dextrose 15% and lidocaine 1% infiltration, Lidocaine 1% infiltration
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Ureteral Stent Placement, Kidney Stone
NSAIDs Stent Study
This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment…
- Trial name
- NCT03638999
- Testing
- Ketorolac Trometamol 30Mg/1mL Injection, Normal saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Multiple Myeloma
A Clinical Study to Evaluate LVIVO-TaVec200 for the Treatment of Relapsed/Refractory Multiple Myeloma
This is a prospective, single-arm, open-label dose-escalation clinical study to evaluate LVIVO-TaVec200 in the treatment of relapsed/refractory multiple myeloma.
- Trial name
- NCT07294625
- Testing
- LVIVO-TaVec200 product
- Where
- 5 sites in China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gut Microbiome, Healthy Adult Male
Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial
The goal of this clinical trial is to learn how the antifungal drug fluconazole affects the gut microbiome and immune system in healthy volunteers.
- Conditions
- Gut Microbiome, Healthy Adult Male, Antifungal Therapy
- Trial name
- FAME (NCT07295314)
- Testing
- Fluconazole 200mg tab
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Liver Cancer, Adult
NIR-II Fluorescence-Guided Hepatectomy Using ICG-Cisplatin Nanoprobes for HCC
This prospective, single-arm exploratory study evaluates the feasibility and safety of a novel ICG-Cisplatin self-assembled nanoprobe (NIR-II NanoM) for fluorescence-guided surgery in patients with Hepatocellular Carcinoma (HCC).
- Trial name
- NCT07295262
- Testing
- ICG-Cisplatin Nanoprobe (NIR-II NanoM), Fluorescence-guided Hepatectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- West China Hospital
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
HPV
PANHPVAX, Study of a New HPV Vaccine in Healthy Volunteers
First-in-human, phase I, single-center, open-label, dose-escalation trial in healthy volunteers. Investigation of safety and tolerability of ascending doses of PANHPVAX, a vaccine against human papilloma L2 antigens formulated…
- Trial name
- PANHPVAX (NCT05208710)
- Testing
- Vaccination with PANHPVAX 10µg, Vaccination with PANHPVAX 40µg, Vaccination with PANHPVAX 100µg
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Contrast-induced Nephropathy
Role of Amlodipine in Reduction of CIN
The aim is to assess the benefit of low dose oral amlodipine in renal protection from contrast induced nephropathy in diabetic patients in intensive care unit
- Trial name
- NCT07291375
- Testing
- Calcium channel blocker, Hydration
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minia University
Analgesia
RM1 Project 1 - tAN Naloxone
This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute transcutaneous auricular neurostimulation (tAN)…
- Trial name
- NCT05490134
- Testing
- Naloxone, Saline
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
IBS - Irritable Bowel Syndrome, Diarrhea
Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator
The purpose of this research is to study the added benefit of treating IBS symptoms with a medication called mirtazapine in treating IBS symptoms when paired with a low-FODMAP diet compared to a low-FODMAP diet alone.
- Trial name
- NCT06684470
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
The goal of this study is to determine how a drug class called glucagon-like peptide-1 receptor agonists (GLP-1Ra) affects people during an early stage of Type 1 Diabetes undergoing clinical teplizumab treatment.
- Trial name
- GLP-TEP (NCT06338553)
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University Medical Center
Non-invasive CAR-T Cell Monitoring, BCMA-targeted PET Imaging
CAR-T Cell Efficacy With Molecular Imaging in Multiple Myeloma
⁶⁸Ga-NOTA-BCMA is a novel, targeted PET tracer under clinical investigation. It is designed to provide a non-invasive method for monitoring the biodistribution and persistence of BCMA CAR-T cells in patients.
- Conditions
- Non-invasive CAR-T Cell Monitoring, BCMA-targeted PET Imaging, CAR-T Cell Biodistribution and Persistence, GMP-compliant Radiopharmaceutical Preparation
- Trial name
- NCT07280793
- Testing
- BCMA-Targeting CAR-T Cell Therapy, PET/CT Imaging
- Volunteers
- 10 people
- Sponsor
- Xuzhou Medical University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.