Clinical trials: sponsored by National Heart, Lung, and Blood Institute (NHLBI)
Cancer, Cardiovascular Disease
Vitamin D and Omega-3 Trial (VITAL)
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram)…
- Trial name
- VITAL (NCT01169259)
- Testing
- vitamin D3, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Severe Aplastic Anemia, MDS (Myelodysplastic Syndrome)
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells
Background: Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia.
- Trial name
- NCT01174108
- Testing
- Miltenyi CD34 Reagent System, Donor derived G-CSF mobilized PBC
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Infection, Bronchial Diseases
Cross-sectional Characterization of Idiopathic Bronchiectasis
Background: Bronchiectasis is a type of lung condition in which the lungs airways are abnormally stretched and widened. This stretching and widening makes it difficult for mucus and other substances to move out of the lungs…
- Conditions
- Infection, Bronchial Diseases, Respiratory Tract Diseases
- Trial name
- NCT01264055
- Where
- 6 sites in United States, Canada
- Volunteers
- 275 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Arterial Hypertension
Spironolactone for Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. In spite of recent advances in treatment, the death rate remains unacceptably high.
- Trial name
- NCT01712620
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV
Quantitative Measurement and Correlates of the Latent HIV Reservoir in Virally Suppressed Ugandans
Background: Human Immunodeficiency Virus (HIV) is the virus that causes AIDS. HIV can hide in the blood for many years, even in people who have their HIV infection under control.
- Trial name
- NCT02154035
- Where
- Uganda
- Volunteers
- 130 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Suicide, Adolescent Behavior
Wearable Suicidal Early Warning System for Adolescents
This study is prospectively enrolling a cohort of adolescent patients who present to the Emergency Department and an inpatient psychiatric adolescent unit with acute suicidality.
- Trial name
- NCT03030924
- Testing
- Solace
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Oregon Health and Science University
Sickle Cell Disease
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
Background: Sickle Cell Disease (SCD) is a blood disorder that occurs mainly in people of African descent. Researchers want to learn more about the painful attacks and complications associated with SCD.
- Trial name
- NCT03049475
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Cardiovascular Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
Background: Heart disease is the leading cause of death, disability, and healthcare expense in the United States. Researchers think a new drug called Fx-5A may be useful to treat different cardiovascular diseases and…
- Trial name
- NCT04216342
- Testing
- Fx-5A peptide complex
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Familial LCAT Deficiency
Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)
Background: High density lipoprotein (HDL), or good cholesterol, moves cholesterol from the artery walls back to the liver. A blood enzyme known as LCAT maintains HDL levels and helps it remove cholesterol from the body.
- Trial name
- NCT04737720
- Testing
- Recombinant LCAT
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Childhood, Metabolic Syndrome
FIT Families Multicomponent Obesity Intervention for African American Adolescents
Obesity is one of the most prevalent medical problems facing children and adolescents today, particularly among African American adolescents where the rate is alarmingly high.
- Trial name
- NCT04974554
- Testing
- FIT, Home-Based Family Support
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Medical University of South Carolina
Cardiac Disease, Critically Ill
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating…
- Conditions
- Cardiac Disease, Critically Ill, Children, Adult
- Trial name
- OPTIC (NCT05055830)
- Testing
- The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care.
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Shift-work Disorder
Role of Sleep Reactivity in Shift Work Disorder
The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental…
- Trial name
- REACT (NCT05424406)
- Testing
- Active phototherapy, Control phototherapy, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Asthma, Asthma Chronic
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
- Conditions
- Asthma, Asthma Chronic, Overweight and Obesity
- Trial name
- NCT06273072
- Testing
- Metformin hydrochloride extended-release tablets
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease
Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management
The Icahn School of Medicine at Mount Sinai will conduct a randomized controlled trial of a self-management support intervention for predominantly minoritized and low-income adults with chronic obstructive pulmonary disease…
- Trial name
- SAMBA COPD (NCT06634810)
- Testing
- Self-Management Support, COPD Education
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypersensitivity Pneumonitis
Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis
The central hypothesis is that a peer coach-delivered intervention that includes cognitive behavioral principles combined with theory-driven patient education will improve health-related quality of life (HRQOL) of patients with…
- Trial name
- RISE-HP (NCT06811389)
- Testing
- Re-imagining Interventions for Support and Education in Hypersensitivity Pneumonitis (RISE-HP), Staying Well
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Weill Medical College of Cornell University
Frailty, Lung Tranplant Candidate
Exercise-based Frailty Intervention in Lung Transplantation (XFIT)
The goal of XFIT study is to measure the safety of an 8-week telehealth-delivered exercise and behavioral training program to treat frailty in lung transplant candidates in their own home.
- Trial name
- XFIT (NCT06960421)
- Testing
- XFIT
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Alpha 1-Antitrypsin Deficiency
Gene Therapy for Alpha 1- Antitrypsin Deficiency
This is a study of gene therapy to treat alpha 1-antitrypsin (AAT) deficiency. This study aims to treat AAT deficiency with a single administration of AAV8hAAT(AVL), a gene therapy that codes for an oxidation resistant form of…
- Trial name
- NCT06996756
- Testing
- AAV8hAAT(AVL)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Weill Medical College of Cornell University
Patient-Reported Outcome Measures (PROMs), Pragmatic Trial
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
The goal of this pragmatic clinical trial is to learn if the WE BEAT program, a 5-week group-based online wellbeing and skill-building program, can help teens with congenital heart disease (CHD) improve their ability to handle…
- Conditions
- Patient-Reported Outcome Measures (PROMs), Pragmatic Trial, Adolescent Congenital Heart Disease, Resiliency-building Intervention
- Trial name
- PHN WBC (NCT07525843)
- Testing
- Telemedicine-based resiliency-building intervention
- Where
- 14 sites in United States
- Volunteers
- 390 people
- Sponsor
- Carelon Research
Diabete Mellitus
Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Study- Formative Aim 3
The purpose of the second phase of the Hypertension Treatment in Nigeria (HTN 2.0) Program is to build upon the success of the first phase of the HTN Program (2020-2023), which implemented the WHO HEARTS package across 60 primary…
- Trial name
- HTN2 (NCT07589387)
- Testing
- Implementation of program based on WHO HEARTS-D guidelines, Metformin, Glimepiride
- Where
- 10 sites in Nigeria
- Volunteers
- 2,800 people
- Sponsor
- Washington University School of Medicine