Clinical trials: sponsored by Karolinska Institutet
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study
Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07292090
- Testing
- Intervention yogabased movements
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD
Brief Summary: Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07348783
- Testing
- Intervention yoga based exercises
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Knee Arthroplasty, Total, Robotic-assisted
RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques
Rationale for conducting the study: The ROCKET study evaluates the clinical and economic outcomes of robot-assisted total knee arthroplasty (RTKR) compared with conventional total knee arthroplasty (TKR).
- Conditions
- Knee Arthroplasty, Total, Robotic-assisted, Osteoarthritis of the Knee
- Trial name
- ROCKETS (NCT06389435)
- Testing
- Robot-assisted total knee arthroplasty, Conventional total knee arthroplasty
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Danderyd Hospital
Nonsuicidal Self Injury, Nonsuicidal Self-Injury
Psychological Treatment for Adolescents With Self-injury Within Intensive Mental Health Outpatient Services: Randomized Controlled Pilot Trial
The overarching aim of this study is to develop and evaluate a new blended treatment format, which combines face-to-face and digital treatment components, for Emotion Regulation Individual Therapy for Adolescents (ERITA).
- Conditions
- Nonsuicidal Self Injury, Nonsuicidal Self-Injury, Self-Harm
- Trial name
- NCT07755774
- Testing
- Blended ERITA, Treatment as Usual (TAU), Concomitant care
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Autism, Sociocommunicative Challenges
Improving Autism Program Quality in Special Education Units: The Use of an APERS-based Model to Support Student Learning and Participation
This study assesses the effect of using the Autism Program Environment Rating Scale (APERS) as a tool for providing feedback, in-service training, and coaching to school staff in order to improve program quality in special…
- Trial name
- NCT07830160
- Testing
- APERS+
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung)
TailorDose Lung: Decentralized TDM of Taxanes and ALK Inhibitors Using Capillary Self-Sampling
This study will evaluate whether people with non-small cell lung cancer (NSCLC) can collect small blood samples themselves using a finger-prick sampling kit.
- Trial name
- TD-Lung (NCT07823725)
- Testing
- True Dose® Capillary Self-Sampling System
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Unresectable Pancreatic Cancer
Efficacy of PERT for PEI in Unresectable Pancreatic Cancer.
This will a be an open label, multicentre, randomized, controlled study in patients with unresectable pancreatic cancer, locally advanced or metastatic, with significant weight loss, and the tumour located in the head of the…
- Trial name
- PERTseverance (NCT06099119)
- Testing
- creon 35.000 Ph.U (R), Best Standarard of Care
- Where
- 4 sites in Italy, Spain and 1 more
- Volunteers
- 100 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Asthma
Primary Care Asthma FeNO Trial
Asthma is a chronic inflammatory respiratory disease that affects people of all ages and of both sexes. It is a common disease and is present in 8-10 % of the population.
- Trial name
- CRAFT (NCT05853809)
- Testing
- FeNO measurement
- Where
- Sweden
- Volunteers
- 3,254 people
- Sponsor
- Region Stockholm
AKI - Acute Kidney Injury, Critical Illness
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive…
- Trial name
- CIILOS (NCT07586059)
- Testing
- continuous renal replacement therapy
- Volunteers
- 500,000 people
- Sponsor
- Karolinska Institutet
Child Behavior Problem, Disruptive Behavior
Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems
The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden…
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559800
- Testing
- YourSkills: Cognitive behavioral therapy for children/youth with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Child Behavior Problem, Disruptive Behavior
Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems
The main aim of this pilot trial is to evaluate preliminary effects and feasibility of a new parent training program for parents of children aged 8-16 years with disruptive behavior (e.g., angry, aggressive or defiant behavior).
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559813
- Testing
- Step-by-step: A cognitive behavioral parent program with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Karolinska Institutet
Backpain, Neck and Shoulder Pain
Implementation of Evidence-based Guidelines for Assessment and Counseling of Patients With Neck and Back Pain in Health Care Centers
The overall aim is to investigate the health outcomes and consequences, from an individual and a societal perspective, of adding licensed Manual Therapists as first-contact healthcare providers in Primary Health Care centers to…
- Trial name
- ALIGN (NCT07825116)
- Testing
- Manual terapeut management
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Alcohol Abuse, Harmful Alcohol Use
Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment
Many people who have risky alcohol use or alcohol dependence do not seek help, often is due to concerns about potential consequences or feelings of shame.
- Conditions
- Alcohol Abuse, Harmful Alcohol Use, Hazardous Alcohol Use, Hazardous Drinking
- Trial name
- NCT06675812
- Testing
- Information intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorders
Effectiveness and Costs of Internet-based Treatment for Harmful Alcohol Use and Face-to-face Treatment in Addiction Care
The purpose of this trial is to compare the effectiveness and costs of a five-module Internet-based treatment program (including therapist support) for harmful alcohol use with the effectiveness and cost of the same treatment…
- Trial name
- NCT02671019
- Testing
- Guide to better alcohol habits
- Where
- Sweden
- Volunteers
- 303 people
- Sponsor
- Karolinska Institutet
Cardio Vascular Disease, Diabetes (DM)
Holistic CRM Care vs Standard of Care in a Primary Care Setting
Cardiovascular disease, high blood pressure, chronic kidney disease, and type 2 diabetes, collectively referred to as Cardio-Renal-Metabolic (CRM) conditions, are among the most common chronic diseases in society.
- Conditions
- Cardio Vascular Disease, Diabetes (DM), Chronic Kidney Disease
- Trial name
- HOPE-CRM (NCT07819383)
- Testing
- CRM care
- Volunteers
- 6,000 people
- Sponsor
- Danderyd Hospital
Obsessive-Compulsive Disorder, Autism Spectrum Disorder
ICBT for OCD in Children With Autism
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the effect durability of a therapist-guided, internet-delivered cognitive-behavior therapy intervention for obsessive-compulsive disorder…
- Trial name
- NCT06582225
- Testing
- Internet-delivered exposure and response prevention (I-ERP), Internet-delivered stress management (I-SM)
- Where
- 3 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Karolinska Institutet
Chiari Malformation Type I
Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey
The goal of this observational survey study is to investigate factors that may affect the health-related quality of life (HRQoL) in adults with Chiari malformation type 1 (CM1).
- Trial name
- NCT07818122
- Where
- Sweden
- Volunteers
- 1,004 people
- Sponsor
- Karolinska Institutet
Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma
Prognostic Evaluation and Systematic Re-Assessment of Cholangiocarcinoma Therapy
Prospective observational cohort study including patients with a diagnosis of intrahepatic/perihilar cholangiocarcinoma at the central regional multidisciplinary conference, to assess therapy response, patient-reported quality of…
- Trial name
- Re-ACT (NCT07814586)
- Volunteers
- 900 people
- Sponsor
- Karolinska University Hospital
Childhood Obesity, Treatment Adherence
The Evira Study: Additional Support During Obesity Treatment
The goal of this clinical trial is to evaluate the effect of adding a digi-physical treatment tool as a complement to the local treatment with obesity medication in adolescents with obesity.
- Trial name
- NCT06836284
- Testing
- Digi-physical treatment tool, Evira, Obesity medication with liraglutide or semaglutide
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
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