Clinical trials: not yet recruiting
Blood Donors, Apheresis
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use
Background: Many different research projects need a steady supply of human blood. Blood donated by screened, healthy people may be used to test new drugs, for example, or to learn how blood cells work.
- Trial name
- NCT07877259
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Clostridioides Difficile Infection
Epidemiology of Clostridioides Difficile Infection (CDI) in Long-term Care Facilities, Assessment of Professional Practices Related to CDI Risk Prevention, and Strategies for Improving Care.
Clostridioides difficile infection (CDI) is the leading cause of infectious diarrhea among older adults. The epidemiology of community-acquired CDI, particularly among residents of long-term care facilities, remains poorly…
- Trial name
- EpiCE (NCT07920627)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cardiometabolic Risk Factors, Mental Health
A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Cross-Sectional Bhutanese Community of Central Ohio Health Study to Understand Acculturation as Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating ...
Background: As of 2021, almost 45 million people in the United States were foreign-born immigrants. South Asians, including people from Bhutan, are the fastest-growing immigrant subgroup in the US.
- Trial name
- NCT06991751
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Breast Cancer Stage I, Colorectal Cancer
Mind-Body Interventions for the Improvement of Quality of Life, Stress, and Sleep Quality Among Survivors of Breast, Prostate, Endometrial, or Colorectal Cancer
This clinical trial studies how well mind-body interventions work in improving quality of life (QOL), stress, and sleep quality among survivors of breast, prostate, endometrial, or colorectal cancer.
- Trial name
- NCT07745023
- Testing
- Media Intervention, Mind-body intervention, Meditation Therapy
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute
Limited Stage Small-Cell Lung Cancer
A Randomized Trial of Standard vs. Hypofractionated Accelerated Radiotherapy for Progression in Limited-Stage Small Cell Lung Cancer
This study aims to determine whether an abbreviated course of thoracic radiotherapy, delivered in five fractions over one week between chemotherapy cycles, improves progression-free survival compared with standard radiotherapy…
- Trial name
- SHARP SCLC (NCT07920549)
- Testing
- Radiation Therapy, Hypofractionated Radiation Therapy, Chemotherapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Focal Onset Seizure
A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Orally Administered Cannabidiol Capsules (AVAT-121) and Epidyolex® in Healthy Adults
This Phase 1 study will evaluate the safety, tolerability, and pharmacokinetics of AVAT-121 in healthy adults. The study includes three parts: Part A: single ascending dose.
- Trial name
- NCT07918469
- Testing
- AVAT-121, AVAT-121 and Epidyolex®
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Avata Biosciences Holdings Ltd
Relapsing Multiple Sclerosis
A Study of Subcutaneously Administered RO7845860 in Participants With Relapsing Multiple Sclerosis
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK) and, pharmacodynamics (PD) of subcutaneously administered RO7845860 in participants with relapsing multiple sclerosis (RMS).
- Trial name
- NOVA-BEAM (NCT07749157)
- Testing
- RO7845860
- Volunteers
- 85 people
- Sponsor
- Hoffmann-La Roche
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids
This phase II trial studies whether psilocybin with psychotherapy is safe and if it works for improving chronic pain in cancer patients who require opioids to manage their pain.
- Trial name
- NCT06827054
- Testing
- Biospecimen Collection, Functional Magnetic Resonance Imaging, Interview
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Tricuspid Regurgitation, Tricuspid Regurgitation Functional
TRI-SUCCESS - Tricuspid Regurgitation Study of the Unica™ Cross-Caval System for the Evaluation of Efficacy and Safety in Significant TR Subjects
Prospective, multi-center, randomized, open-label, controlled pivotal study to assess the safety and effectiveness of the Innoventric Unica™ heterotopic cross-caval stent with OMT compared to OMT alone in the treatment of severe…
- Trial name
- TRI-SUCCESS (NCT07919366)
- Testing
- Innoventric Unica™ System
- Volunteers
- 510 people
- Sponsor
- Innoventric LTD
Respiratory Tract Infections (RTI), Lung Ultrasound
Ultrasound Findings in a Pediatric Population
The purpose of this study is to investigate whether focused ultrasound of the chest can be used in a practical way in children with respiratory symptoms.
- Trial name
- NCT07919613
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Odense University Hospital
Post-Acute COVID-19 Syndrome
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years.
- Trial name
- NCT07388550
- Testing
- Keytruda
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ebola-Bundibugyo Virus Disease (Ebola-BDBV)
A Study to Investigate the Safety and Immunogenicity of mRNA-1469 in African Participants 1 to 65 Years of Age
The main objective of this trial is to evaluate the safety of mRNA-1469
- Trial name
- NCT07919197
- Testing
- mRNA-1469
- Where
- Uganda
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Substance Use Disorder (SUD), Opioid Use Disorder
Disease Intervention Specialist (DIS) for SUD
This prospective observational study evaluates three Disease Intervention Specialist service models designed to proactively identify and support adults at risk for substance use disorder.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use
- Trial name
- DIS-SUD (NCT07875361)
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Ohio State University
Hemiplegic Shoulder Pain
Laser Therapy Versus Transcutaneous Electical Nerve Stimulation at Hemiplegic Shoulder Pain
This study aimed to investigate whether laser and Transcutaneous Electirical Nerve Stimulationapplied in addition to conventional physical therapy exercises in hemiplegic shoulder pain seen in patients with stroke provides an…
- Trial name
- NCT07918157
- Testing
- Laser therapy, Transcutaneus electirical nerve stimulation, control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hitit University
Bladder Cancer
DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder Cancer
This is a prospective, open-label, single-arm exploratory clinical study evaluating the efficacy and safety of disitamab vedotin (RC48) plus toripalimab with cetirizine and mecobalamin in patients with locally advanced…
- Trial name
- NCT07853053
- Testing
- Disitamab Vedotin, Toripalimab, Cetirizine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
An Overview of Vaccination Coverage Among Patients Receiving Treatment for Breast Cancer at the ICO: Identifying Factors Associated With Vaccination Uptake and Improved Prevention
Primary prevention, vaccination, ,state of vaccination coverage in oncology, , breast cancer patients, factors influencing adherence in order to improve prevention.
- Trial name
- VAC-SEIN (NCT07888881)
- Testing
- questionnaire on vaccination status
- Volunteers
- 312 people
- Sponsor
- Institut Cancerologie de l'Ouest
Stroke
The Effects of an Augmented Reality-Based Mirror Therapy System in Patients With Stroke
Objective The aim of this study is to investigate the effects of an augmented reality-based mirror therapy system (MirrARm), developed using sensor-based tracking and visual feedback principles, on upper extremity motor recovery…
- Trial name
- NCT07533734
- Testing
- Augmented Reality-Based Mirror Therapy, Conventional Mirror Therapy, Conventional Physiotherapy Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Pain
Screening Protocol
This study is a screening evaluation for volunteers who are interested in participating in National Center for Complementary and Integrative Health (NCCIH) research studies about pain and related processes, such as emotion, mood…
- Trial name
- NCT07712874
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Idiopathic Parkinson Disease
Longitudinal Observation of Neurodegeneration in Parkinson's Disease Using Molecular Imaging and Blood Biomarkers
This is a single-center, prospective observational study of patients with moderate-to-advanced primary Parkinson's disease (PD). PD is the second most common neurodegenerative disease.
- Trial name
- PD (NCT07919262)
- Testing
- Brain PET Examination, Clinical assessment, blood sampling and brain PET examination
- Volunteers
- 36 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Lymphoblastic Leukemia, Hematopoietic Stem Cell Transplantation
Busulfan-Based Versus TBI-Based Conditioning for Adult ALL-CR2 Allo-HSCT
This is an multicenter, non-inferiority randomized controlled trial. Adult patients (14-65 years) with acute lymphoblastic leukemia in second complete remission (CR2) scheduled for allogeneic hematopoietic stem-cell…
- Trial name
- NCT07919470
- Testing
- Chemotherapy-based Conditioning Regimen, TBI-based conditioning
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University People's Hospital
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