Clinical trials: sponsored by Karolinska Institutet
RSV Immunisation
RSV Immunogenicity Study in the Elderly (RISE)
Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections leading to hospitalizations in infants and in elderly.
- Trial name
- RISE (NCT07203365)
- Testing
- This study examines immune response differences Arexvy between individuals aged 80+ and adults aged 60-65
- Where
- 2 sites in Sweden
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Karin Karin Loré
Hip Osteoarthritis
MOVE-HIP: Ceramic Hip Resurfacing Versus Total Hip Arthroplasty Using Activity Monitoring
MOVE-HIP is a pragmatic, multicenter randomized clinical trial comparing ceramic hip resurfacing arthroplasty with contemporary total hip arthroplasty in adults with symptomatic hip osteoarthritis who are considered clinically…
- Trial name
- MOVE-HIP (NCT07839403)
- Testing
- Ceramic-on-Ceramic Hip Resurfacing Arthroplasty, Contemporary Total Hip Arthroplasty
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Danderyd Hospital
Intoxication, Delirium Tremens (DTs)
Preventox - a Digital Intervention for Patients With Intoxications in Intensive Care
Background and purpose At present, occasional referral to psychiatric or addiction services is the only aftercare option offered following an intoxication/overdose requiring intensive care.
- Conditions
- Intoxication, Delirium Tremens (DTs), Poisoning by Psychoactive Substances, Suicidal Attempt
- Trial name
- NCT07819500
- Testing
- Preventox, a digital self-help tool for patients with intoxications in intensive care., Preventox control group
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD
Brief Summary: Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07348783
- Testing
- Intervention yoga based exercises
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study
Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07292090
- Testing
- Intervention yogabased movements
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Mental Health Issue, Mental Disorder
A Trial of Two Universal Programs for Parents of Teenagers
Group-based and internet-delivered parenting programs may help parents improve their communication and relationships with their children.
- Conditions
- Mental Health Issue, Mental Disorder, Adolescent Behavior, Adolescent Development
- Trial name
- NCT06366438
- Testing
- ABC-teen, ParentWeb
- Where
- 58 sites in Sweden
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Autism, Sociocommunicative Challenges
Improving Autism Program Quality in Special Education Units: The Use of an APERS-based Model to Support Student Learning and Participation
This study assesses the effect of using the Autism Program Environment Rating Scale (APERS) as a tool for providing feedback, in-service training, and coaching to school staff in order to improve program quality in special…
- Trial name
- NCT07830160
- Testing
- APERS+
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Nonsuicidal Self Injury, Nonsuicidal Self-Injury
Psychological Treatment for Adolescents With Self-injury Within Intensive Mental Health Outpatient Services: Randomized Controlled Pilot Trial
The overarching aim of this study is to develop and evaluate a new blended treatment format, which combines face-to-face and digital treatment components, for Emotion Regulation Individual Therapy for Adolescents (ERITA).
- Conditions
- Nonsuicidal Self Injury, Nonsuicidal Self-Injury, Self-Harm
- Trial name
- NCT07755774
- Testing
- Blended ERITA, Treatment as Usual (TAU), Concomitant care
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Knee Arthroplasty, Total, Robotic-assisted
RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques
Rationale for conducting the study: The ROCKET study evaluates the clinical and economic outcomes of robot-assisted total knee arthroplasty (RTKR) compared with conventional total knee arthroplasty (TKR).
- Conditions
- Knee Arthroplasty, Total, Robotic-assisted, Osteoarthritis of the Knee
- Trial name
- ROCKETS (NCT06389435)
- Testing
- Robot-assisted total knee arthroplasty, Conventional total knee arthroplasty
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Danderyd Hospital
Unresectable Pancreatic Cancer
Efficacy of PERT for PEI in Unresectable Pancreatic Cancer.
This will a be an open label, multicentre, randomized, controlled study in patients with unresectable pancreatic cancer, locally advanced or metastatic, with significant weight loss, and the tumour located in the head of the…
- Trial name
- PERTseverance (NCT06099119)
- Testing
- creon 35.000 Ph.U (R), Best Standarard of Care
- Where
- 4 sites in Italy, Spain and 1 more
- Volunteers
- 100 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung)
TailorDose Lung: Decentralized TDM of Taxanes and ALK Inhibitors Using Capillary Self-Sampling
This study will evaluate whether people with non-small cell lung cancer (NSCLC) can collect small blood samples themselves using a finger-prick sampling kit.
- Trial name
- TD-Lung (NCT07823725)
- Testing
- True Dose® Capillary Self-Sampling System
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Child Behavior Problem, Disruptive Behavior
Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems
The main aim of this pilot trial is to evaluate preliminary effects and feasibility of a new parent training program for parents of children aged 8-16 years with disruptive behavior (e.g., angry, aggressive or defiant behavior).
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559813
- Testing
- Step-by-step: A cognitive behavioral parent program with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Karolinska Institutet
Asthma
Primary Care Asthma FeNO Trial
Asthma is a chronic inflammatory respiratory disease that affects people of all ages and of both sexes. It is a common disease and is present in 8-10 % of the population.
- Trial name
- CRAFT (NCT05853809)
- Testing
- FeNO measurement
- Where
- Sweden
- Volunteers
- 3,254 people
- Sponsor
- Region Stockholm
Child Behavior Problem, Disruptive Behavior
Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems
The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden…
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559800
- Testing
- YourSkills: Cognitive behavioral therapy for children/youth with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
AKI - Acute Kidney Injury, Critical Illness
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive…
- Trial name
- CIILOS (NCT07586059)
- Testing
- continuous renal replacement therapy
- Volunteers
- 500,000 people
- Sponsor
- Karolinska Institutet
Backpain, Neck and Shoulder Pain
Implementation of Evidence-based Guidelines for Assessment and Counseling of Patients With Neck and Back Pain in Health Care Centers
The overall aim is to investigate the health outcomes and consequences, from an individual and a societal perspective, of adding licensed Manual Therapists as first-contact healthcare providers in Primary Health Care centers to…
- Trial name
- ALIGN (NCT07825116)
- Testing
- Manual terapeut management
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorders
Effectiveness and Costs of Internet-based Treatment for Harmful Alcohol Use and Face-to-face Treatment in Addiction Care
The purpose of this trial is to compare the effectiveness and costs of a five-module Internet-based treatment program (including therapist support) for harmful alcohol use with the effectiveness and cost of the same treatment…
- Trial name
- NCT02671019
- Testing
- Guide to better alcohol habits
- Where
- Sweden
- Volunteers
- 303 people
- Sponsor
- Karolinska Institutet
Alcohol Abuse, Harmful Alcohol Use
Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment
Many people who have risky alcohol use or alcohol dependence do not seek help, often is due to concerns about potential consequences or feelings of shame.
- Conditions
- Alcohol Abuse, Harmful Alcohol Use, Hazardous Alcohol Use, Hazardous Drinking
- Trial name
- NCT06675812
- Testing
- Information intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Cardio Vascular Disease, Diabetes (DM)
Holistic CRM Care vs Standard of Care in a Primary Care Setting
Cardiovascular disease, high blood pressure, chronic kidney disease, and type 2 diabetes, collectively referred to as Cardio-Renal-Metabolic (CRM) conditions, are among the most common chronic diseases in society.
- Conditions
- Cardio Vascular Disease, Diabetes (DM), Chronic Kidney Disease
- Trial name
- HOPE-CRM (NCT07819383)
- Testing
- CRM care
- Volunteers
- 6,000 people
- Sponsor
- Danderyd Hospital