Clinical trials: sponsored by Johns Hopkins University
Critical Illness
PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children
Recent decreases in Pediatric Intensive Care Unit (PICU) mortality rates have been offset by increased morbidity and length of stay for vulnerable young patients.
- Trial name
- PICU Up! (NCT03860168)
- Testing
- PICU Up!
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Johns Hopkins University
Glioblastoma Multiforme of Brain
MRSI to Predict Response to RT/TMZ ± Belinostat in GBM
In the first phase of this study (Cohort 1), the investigators will determine the feasibility of adding MRSI to the evaluation of newly-diagnosed GBM patients treated with standard RT/TMZ and determine whether magnetic resonance…
- Trial name
- NCT02137759
- Testing
- Standard Radiation Therapy, Standard Temozolomide, Belinostat
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Chronic Pain, Opioid-use Disorder
Pain and Opioids: Integrated Treatment In Veterans
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD).
- Conditions
- Chronic Pain, Opioid-use Disorder, Opioids; Harmful Use
- Trial name
- POSITIVE (NCT04648228)
- Testing
- ACT+MBRP, Education control
- Where
- 4 sites in United States
- Volunteers
- 157 people
- Sponsor
- University of New Mexico
Behavior Problem
Tailoring CPP for the Foster Care Setting
The primary objective of this study is to tailor the Chicago Parent Program, an evidence-based parent training program, for the foster care setting and pilot the content in two cohorts of foster and kinship caregivers (Gross et…
- Trial name
- CPP-FC (NCT05856435)
- Testing
- Chicago Parent Program for Foster Care
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cognitive Impairment, Perceived Stress
Robot-Assisted Meditation for Older Adults With Cognitive Concerns
While traditional app-based mindfulness meditation programs relying solely on audio guidance have shown potential benefits for older adults, the programs often face challenges such as low engagement.
- Trial name
- NCT07435220
- Testing
- Robot-Guided Meditation, Audio-Only Robot
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Transplant;Failure,Kidney, Transplant; Failure, Liver
Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant
Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation?…
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Liver, Adherence, Medication, Adherence, Patient
- Trial name
- NCT05613010
- Testing
- mHealth Messaging Intervention Group
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Johns Hopkins University
HIV, Violence, Gender-Based
Development and Evaluation of a PrEP Decision Aid for Women Seeking Domestic Violence Services in Baltimore
This study is designed to develop and test an individual decision aid for pre-exposure prophylaxis (PrEP) tailored to Black women who have been exposed to intimate partner violence and are working with a domestic violence service…
- Conditions
- HIV, Violence, Gender-Based, Pre-Exposure Prophylaxis
- Trial name
- NCT05614492
- Testing
- Individual PrEP Decision Aid, CDC PrEP Video, Shared PrEP Decision Aid
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Opioid Use Disorder
Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment
This is the third phase of the mPeer4Life study - the Trial Phase, will be evaluating the intervention that was developed based on the Formative and Pilot Phases.
- Trial name
- mPeer4Life (NCT07900828)
- Testing
- Mobile phone-assisted intervention, Peer navigator, Standard of care referral for out-patient MAT
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Medical Visualization, Medical Illustration
Consensus And Norms for Medical Visualization Academic Standards Study - A Modified Delphi Study
The goal of this observational study (modified Delphi consensus study) is to establish an international expert consensus on professional standards for medical visualization in medical visualization experts from from around the…
- Conditions
- Medical Visualization, Medical Illustration, Consensus
- Trial name
- CANVAS (NCT07684703)
- Testing
- Delphi procedure
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neuropathic Pain, Chronic Pain
Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain
This is a study evaluating the Scrambler Therapy device as a non-invasive treatment for neuropathic pain in pediatric oncology patients with metastatic bone disease.
- Trial name
- PEACE-NP (NCT07264920)
- Testing
- Scrambler Therapy MC-5A Device
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University
Behavior Problem, Parenting
Chicago Parent Program for Foster and Kinship Caregivers
The primary objective of this study is to test the effects of an evidence-based prevention intervention (CPP) adapted for foster and kinship caregivers of young children (FC; foster care) on caregiver competence and child…
- Trial name
- NCT06170047
- Testing
- Chicago Parent Program for Foster Care, Usual Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetes, Cerebrovascular Disease
Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)
The Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study is an interdisciplinary, community-based, prospective longitudinal epidemiologic study examining the influences of race and socioeconomic status…
- Conditions
- Diabetes, Cerebrovascular Disease, Age-Associated Decline, Cardiovascular Disease
- Trial name
- NCT01323322
- Where
- United States
- Volunteers
- 3,720 people
- Sponsor
- National Institute on Aging (NIA)
Genetic Counseling, Inherited Cardiac Disease
Clinical Trial of the Sequence of Cardiovascular Genetic Counseling and Testing
Although pre-test genetic counseling is widely recommended and has come to dominate genetic counseling practice, tailored results-focused genetic counseling could both increase genetic counseling efficiency and improve genetic…
- Trial name
- RESEQUENCEGC (NCT05422573)
- Testing
- post-test cardiovascular genetic counseling with pre-test education by video, required phone call with genetic counselor pre-test, optional phone call with genetic counselor pre-test
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Johns Hopkins University
Breast Cancer, Breast Cyst
Advanced Ultrasound Signal Processing of Suspicious Breast Images
This study aims to investigate recent developments in ultrasound signal processing to determine if these new techniques can enhance the visibility of important features of interest in breast ultrasound images.
- Conditions
- Breast Cancer, Breast Cyst, Microcalcification
- Trial name
- AUSPICIOUS (NCT07206888)
- Testing
- Imaging
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Health Equity, Cardiovascular Diseases
Techquity by FAITH!
The goal of this clinical trial is to engage African-American churches via an established community-academic partnership (FAITH! Program) to build capacity to promote cardiovascular health and digital health equity in…
- Trial name
- NCT06187077
- Testing
- DHA-Enhanced FAITH! App, FAITH! App
- Where
- United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bladder Cancer
Gender Related Coping and Survivorship for Genitourinary Cancers
This research is being done to learn more about coping and survivorship of women with bladder cancer, specifically regarding psychosocial distress and sexual dysfunction.
- Trial name
- NCT05649306
- Testing
- Additional Education, Questionnaires, Attendance Diary
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
HIV, HIV - Human Immunodeficiency Virus
Bwelela Easy Study
Treatment interruption in HIV care is one of the most enduring challenges to HIV programs globally and is associated with high rates of detectable virus in the blood and overall morbidity and mortality.
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Treatment Interruption, Reengagement
- Trial name
- NCT07900750
- Testing
- Standard of Care - Routine Phone Outreach / Standard of Care - Routine Care and Counseling (SOC-RPO/SOC-RCC), Standard of Care - Routine Phone Outreach / Navigation (SOC-RPO/NAV), Standard of Care - Routine Phone Outreach / Navigation plus Community-Based Medication Delivery (SOC-RPO/NAV+CB-Med)
- Where
- Zambia
- Volunteers
- 1,500 people
- Sponsor
- Washington University School of Medicine
Food Allergy
Oral Food Challenge After One to Two Doses of Omalizumab Treatment for Food Allergy
The goal of this clinical trial is to learn how quickly omalizumab begins to work in people with food allergy. The main question it aims to answer is: Does omalizumab begin to work as early as 2 to 4 weeks after after starting…
- Trial name
- NCT07845552
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder, Alcohol Related Liver Disease
Peer Support for Liver Transplant Recipients With History of ALD
Liver transplant (LT) recipients with a history of alcohol-related liver disease (ALD) may encounter various psychosocial and medical challenges during post-LT recovery, even beyond the initial post-transplant period.
- Conditions
- Alcohol Use Disorder, Alcohol Related Liver Disease, Liver Transplant Recipient
- Trial name
- THRIVE (NCT07397598)
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins University
Healthy
Deliver-EE: Evaluating Effects of Meal Delivery
This study will randomly assign 2,300 older adults on waiting lists at fourteen Meals on Wheels programs in Florida, Illinois, Maryland, Tennessee, Texas, North Carolina, South Carolina, and California into two groups who will…
- Trial name
- NCT05357261
- Testing
- Wellness Check and Socialization, Prepared Meals
- Where
- 14 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Brown University
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