Clinical trials: sponsored by Duke University
Hepatocellular Carcinoma (HCC), Liver Cirrhosis
FAST (Focused Abbreviated Screening Technique)-MRI Study
The purpose of this study is to compare the diagnostic value of a reconstructed abbreviated Magnetic Resonance Imaging (MRI) from a full clinical exam, compared to ultrasound (US) for screening of liver cancer.
- Trial name
- NCT04539717
- Where
- 2 sites in United States
- Volunteers
- 820 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Pain
Group Acupuncture for Pain
The goal of this study is to learn if group acupuncture is acceptable and feasible as a treatment for chronic pain in adults living in rural North Carolina, with the aim of improving access to equitable pain care.
- Trial name
- GAIN (NCT07909473)
- Testing
- Group Acupuncture Intervention
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Duke University
Pancreatic Ductal Adenocarcinoma (PDAC)
A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer
The purpose of this study is to assess the safety, feasibility, and recommended dose of navlimetostat (BMS-986504) combined with mFOLFIRINOX before and after surgery in patients with localized pancreatic cancer with MTAP deletion.
- Trial name
- M-POP (NCT07905131)
- Testing
- Navlimetostat, mFOLFIRINOX Treatment Regimen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Daniel Nussbaum, M.D.
Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta.
- Trial name
- TITAN:SvS (NCT03536312)
- Testing
- Thoracic Aortic Surgery
- Where
- 31 sites in United States, Canada and 1 more
- Volunteers
- 610 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Central Post-Stroke Pain, Stroke
Accelerated Theta-Burst Stimulation for Refractory Central Post-Stroke Pain
This pilot study aims to evaluate the feasibility, safety, and preliminary efficacy of accelerated intermittent theta burst stimulation (aiTBS) as a noninvasive neuromodulation treatment for individuals with severe, refractory…
- Conditions
- Central Post-Stroke Pain, Stroke, Ischemic Stroke and Hemorrhagic Stroke
- Trial name
- NCT07909954
- Testing
- High-dose accelerated intermittent theta burst stimulation (aiTBS), Low-dose accelerated intermittent theta burst stimulation (aiTBS)
- Volunteers
- 30 people
- Sponsor
- Duke University
Cancer
Improving Adherence to Chronic Disease Medication Regimens Among Patients With Recently Diagnosed Cancer
This pilot study evaluates a pharmacist-led medication adherence intervention and Medisafe mobile application among patients with newly diagnosed cancer and multimorbidity.
- Trial name
- NCT07811258
- Testing
- Medisafe Medication Management Program, Pharmacist-Led Medication Review
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Chronic Pain, Opioid-use Disorder
Pain and Opioids: Integrated Treatment In Veterans
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD).
- Conditions
- Chronic Pain, Opioid-use Disorder, Opioids; Harmful Use
- Trial name
- POSITIVE (NCT04648228)
- Testing
- ACT+MBRP, Education control
- Where
- 4 sites in United States
- Volunteers
- 157 people
- Sponsor
- University of New Mexico
Malaria,Falciparum, Malaria in Pregnancy
Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics
The purpose of the INTREPiD study is to compare 1st trimester screening for malaria parasites with a high-sensitivity malaria rapid diagnostic test followed by treatment of test-positive women with artemether-lumefantrine (AL)…
- Conditions
- Malaria,Falciparum, Malaria in Pregnancy, Malaria in Childbirth, Pregnancy
- Trial name
- INTREPiD (NCT05757167)
- Testing
- Malaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL)
- Where
- 2 sites in Democratic Republic of the Congo, Kenya
- Volunteers
- 2,174 people
- Sponsor
- Duke University
Percutaneous Coronary Intervention, Peripheral Endovascular Intervention
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization.
- Trial name
- V-INTERVENTION (NCT06909565)
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 149 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- Duke University
Coronavirus Infection
Pancoronavirus Vaccine Study in Healthy Adults Ages 18-55
The purpose of this Phase I trial is to determine the breadth of immune response elicited by vaccination against betacoronaviruses and assess the safety, reactogenicity, and immunogenicity of Cov-RBD-scNP-001 with or without…
- Trial name
- NCT07902583
- Testing
- Cov-RBD-scNP-001, ACU-026-001-1
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer, Arthralgia
Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia
The main goal of this clinical trial is to test benefits of completing online pain coping skills training program in women who have been diagnosed with stage I-III breast cancer, who have completed their primary cancer treatment…
- Conditions
- Breast Cancer, Arthralgia, Pain, Chronic
- Trial name
- NCT05703178
- Testing
- Online Pain Coping Skills Training, Education
- Where
- 2 sites in United States
- Volunteers
- 452 people
- Sponsor
- Northwestern University
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Community-Empowerment and Environmental Enrichment-based Co-management (CEEEC) Model and Mechanisms for Improving Health of Older Stroke Patients With Multimorbidity
This study is a cluster randomized controlled trial with a 2×2 factorial design conducted in community health centers in Kunshan, Wuhan and Shanghai, China.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity, Stroke
- Trial name
- CEEEC (NCT06975501)
- Testing
- Exercise Intervention, Cognitive Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Duke Kunshan University
Emotion Dysregulation
DBT-P Treatment Study
The goal of this study is to find out if improving emotion regulation skills use during pregnancy reduces maternal stress and improves heart rate.
- Trial name
- REACH (NCT06963801)
- Testing
- Moms2B, DBT-P
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Cardiac Arrest
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest.
- Trial name
- NCT04660526
- Testing
- Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use.
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Duke University
Dementia
The Impact of Music Intervention on Sleep
The primary purpose of this Stage 1b NIH-funded clinical trial (K23AG073618, PI Petrovsky) is to determine the efficacy of a 1-month music intervention (Calming Music Personalized for Sleep Enhancement in PeRsons living with…
- Trial name
- NCT06088810
- Testing
- CoMPoSER intervention group, Sleep Education
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Duke University
Myocardial Infarction
Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
The purpose of this registry is to address optimal platelet inhibition during the early management of MI patients prior to coronary angiography or CABG.
- Trial name
- CAMEO (NCT04076813)
- Where
- 11 sites in United States
- Volunteers
- 5,050 people
- Sponsor
- Chiesi USA, Inc.
Overweight or Obesity
Healthy Living BEYOND Weight Study
The Healthy Living BEYOND Weight Study is an observational research study of participants living with overweight and obesity. The principal objectives for this project will be to answer fundamental unanswered questions regarding…
- Trial name
- NCT07075341
- Testing
- None - Observational study
- Where
- United States
- Volunteers
- 1,000,000 people
- Sponsor
- American Heart Association
Amyotrophic Lateral Sclerosis ALS
ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments
GenieUs developed an analysis platform that will be tested to separate study participants with ALS into four categories based on blood work.
- Trial name
- NCT06429059
- Testing
- Astaxanthin, Protandim, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Hypertension, HIV
Community Health Worker Optimization of Antihypertensive Care in HIV
To adapt and assess the implementation and preliminary effectiveness of an integrated COBRA and CHAMP multi-component community health worker-delivered hypertension intervention in improving blood pressure control among PLWH in…
- Trial name
- COACH (NCT06503991)
- Testing
- Community Health Worker (CHW)-delivered Hypertension Management Pilot (CHAMP), Control of Blood Pressure and Risk Attenuation (COBRA)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Duke University
Mild Cognitive Impairment
Network-guided TMS in Early Alzheimer's Disease
The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function…
- Trial name
- NetTMS (NCT04549155)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Duke University
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