Clinical trials: Early Phase 1
Ototoxicity, Drug-Induced
Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy
This study will attempt to demonstrate the efficacy of Sodium Thiosulfate (STS) in preventing hearing loss in patients re-treated with cisplatin-based therapy according to regimens Cisplatin and STS (regimen CS) and Cisplatin…
- Trial name
- NCT05756660
- Testing
- Sodium Thiosulfate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Volunteer
Positron Emission Tomography (PET) Imaging of Reactive Oxygen and Nitrogen Species: Human Observation of Retention and Safety of [18F]-Fluoroedaravone
This first-in-human research study will test the safety of a new PET imaging tracer called[18F]fluoroedaravone ([18F]FEDV) in healthy adults.
- Trial name
- NCT07801976
- Testing
- [18F]Fluoroedaravone ([18F]FEDV), PET/CT Imaging
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Obesity &Amp; Overweight
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment
This clinical study investigates how blocking the hunger-related ghrelin receptor affects appetite and metabolism in individuals with obesity who are treated with semaglutide (a GLP-1 receptor agonist).
- Trial name
- SILENCED (NCT07171723)
- Testing
- Liver-Expressed Antimicrobial Peptide 2 (LEAP2)
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Pouchitis, UC - Ulcerative Colitis
Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC)
The goal of this single-arm, prospective clinical trial is to assess the clinical efficacy and safety of oral Aeromonas sp. MTB-specific phage therapy in adult participants aged 18-70 years with pouchitis following ileal…
- Trial name
- NCT07878026
- Testing
- MTB-targeted phage therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jinling Hospital, China
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Osteopenia
Melatonin and Osteogenic Loading on Osteopenia
This study will be assessing the efficacy of melatonin and/or osteogenic loading on modulating bone health in an osteopenic population.
- Trial name
- MelaOstrong (NCT04233112)
- Testing
- Melatonin 5 mg, Osteogenic loading, Mock for Osteogenic Loading
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Duquesne University
Cannabis Use Disorder
Cannabinoids and Biological Reactivity to Stress
The goal of this study is to test the impact of two drugs that produce temporary stress-like symptoms, both in isolation and together, on cannabis use motivation in individuals with Cannabis Use Disorder.
- Trial name
- COBRAS (NCT06430580)
- Testing
- Hydrocortisone Oral, Yohimbine Hydrochloride
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Florida State University
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Background: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are blood cancers that affect certain white blood cells. Advanced forms of these diseases are difficult to treat.
- Trial name
- NCT07428707
- Testing
- Pirtobrutinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Persistent Postural Perceptual Dizziness, Vestibular Migraine
Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness
Both persistent postural-perceptual dizziness (PPPD) and vestibular migraine (VM) are common diagnoses in patients presenting to physicians for evaluation of vestibular symptoms such as dizziness and vertigo.
- Conditions
- Persistent Postural Perceptual Dizziness, Vestibular Migraine, Chronic Dizziness
- Trial name
- NCT07374640
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Vaccinia, Virus Diseases
Evaluating the Human Immune Response to the JYNNEOS Vaccine
This study is designed to evaluate the magnitude and duration of the human adaptive immune response to the JYNNEOS Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine in the blood, lung mucosa, skin and bone marrow.
- Trial name
- NCT06366672
- Testing
- JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection, Phlebotomy, Research bronchoscopy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Active Control (Robot on Screen), Adaptive Assistive Robot
NRI: Robot-Assisted Longitudinal Physical and Cognitive Exercise Interventions for Older Veterans
In this protocol, the researchers will shift from the past short-term methods to a longer-term deployment and study of a robotic system in a skilled nursing facility setting.
- Trial name
- NCT07885813
- Testing
- Exercise with Assistive Robot
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Endometrial Cancer
A Study of a Weight Loss Intervention in People With Endometrial Cancer
The researchers are doing this study is to find out whether tirzepatide and semaglutide are practical (feasible) for weight management and blood sugar control for endometrial cancer patients undergoing chemotherapy.
- Trial name
- NCT06751589
- Testing
- Tirzepatide
- Where
- 7 sites in United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Grade II Glioma, Grade III Glioma
Implantable Microdevice In Primary Brain Tumors
This pilot study will assess the safety and feasibility of using an implantable microdevice to measure local intratumor response to chemotherapy and other clinically relevant drugs in malignant brain tumors.
- Conditions
- Grade II Glioma, Grade III Glioma, Grade IV Glioma, Astrocytoma
- Trial name
- NCT04135807
- Testing
- Microdevice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oliver Jonas
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT07886606
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation, Prostate Cancer
RET-Targeted Molecular Imaging Probes in Prostate Cancer
The goal of this observational diagnostic imaging study is to evaluate the value of RET-targeted PET/CT molecular imaging in diagnosing neuroendocrine prostate cancer (NEPC) and in assessing disease activity, treatment response…
- Trial name
- NCT07886138
- Testing
- RET-targeted PET/CT molecular imaging, PSMA-targeted PET/CT imaging
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Malignant Tumour
Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human…
- Trial name
- NCT06995976
- Testing
- 68Ga-dPNE, 18F-FDG
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Drug-Induced Acute Liver Injury, Tuberculosis (TB)
Silymarin Versus N-Acetylcysteine as Protective Effect Against Anti-tuberculosis Drugs Induced Liver Injury.
Worldwide, tuberculosis (TB) infection caused by Mycobacterium Tuberculosis, remains one of the top 10 deadly diseases having a significant socioeconomic burden in the world, especially in developing countries.
- Trial name
- NCT07875322
- Testing
- Antituberculosis drugs Group
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma
SBRT + Atezolizumab + Bevacizumab in Resectable HCC
This study is evaluating the safety and tolerability of neoadjuvant stereotactic body radiation therapy (SBRT) with atezolizumab and bevacizumab for treating resectable hepatocellular carcinoma.
- Trial name
- NCT04857684
- Testing
- Atezolizumab, Bevacizumab, Stereotactic Beam Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital