Clinical trials: enrolling by invitation
Cataract
Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers
Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency…
- Trial name
- NCT06649799
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
IOL, Cataract
Clinical Outcomes of Patients with LAL+ in At Least One Eye
The objective of this study is to collect data on bilateral pseudophakic patients implanted with the RxSight Light Adjustable Lens+ (LAL+) in at least one eye
- Trial name
- NCT06650358
- Testing
- Light Adjustable Lens+
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Frank A. Bucci, Jr., M.D.
Tobacco Use, Tobacco Smoking
Enhancing Equity in Smoke-free Housing
The goal of this clinical trial is to learn about the acceptability, feasibility, and effectiveness of smoke-free housing policy implementation in Permanent Supportive Housing communities.
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder
- Trial name
- NCT06042361
- Testing
- Smokefree Implementation Framework and Toolkit
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Malocclusion, Angle Class I
The Efficacy of Lingual Aligners in Adults.
The goal of this clinical trial is to test the effectiveness of lingual aligners in adults. The main question to answer is: Are lingual aligners effective in achieving desired and predicted tooth movements?
- Trial name
- NCT06050655
- Testing
- Lingual aligners
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Women, Excess Weight
Olive Leaf Extract, Meta-inflammation, Anxiety, and Excess Weight
Excess Weight is accompanied by a process that produces a low-grade inflammation state, called meta-inflammation. Anxiety is also associated with inflammation. Inflammation is closely related to oxidative stress.
- Conditions
- Women, Excess Weight, Anxiety Disorders
- Trial name
- NCT06485349
- Testing
- Olive Leaf Extract (OLE)
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- University of Guadalajara
Well Being
Comparison of Nutritional Information With Iron-succinate Supplementation in Healthy Women
The primary aim of the current study is to evaluate the effects of dietary nutritional advice with regards to iron rich food sources or a daily oral supplement of 100 mg ferrous iron succinate in 80 menstruating, healthy women…
- Trial name
- Fe-Health (NCT06648018)
- Testing
- Nutritional information, Iron-succinate
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- University Hospital, Linkoeping
Obesity, fMRI
Clinical Classification and Imaging Markers in Patients of Obesity
This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.
- Conditions
- Obesity, fMRI, Clinical Classification
- Trial name
- NCT06649071
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Carpal Tunnel Syndrome (CTS)
Efficacy of Ozone Therapy and Splint in Carpal Tunnel Syndrome
This study will investigate the effectiveness of repeated ozone therapy combined with splint therapy for carpal tunnel syndrome (CTS).CTS patients will be split into two groups: ozone plus splint and splint only.
- Trial name
- NCT06649461
- Testing
- ozone injections, Splint
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Selcuk University
Laxity; Skin
Safety and Efficacy of Matrix Pro for Eyebrow Lift and Lift of Submental/Neck Laxity
Prospective, non-randomized, multi-center, pivotal clinical trial
- Trial name
- NCT06640998
- Testing
- Matrix Pro
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
HFpEF - Heart Failure With Preserved Ejection Fraction
The Gut Microbiota and Metabolites in HFpEF
Heart failure (HF) with preserved ejection fraction (HFpEF) has emerged as a critical public health concern. The annual mortality rate for HFpEF is approximately 15%, accompanied by a re-hospitalization rate of nearly 80%.
- Trial name
- NCT06645535
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Triple Negative Breast Cancer
Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the…
- Trial name
- NCT06646263
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Institute of Applied Biosciences
Chronic Myeloid Leukemia (CML)
Long-term Risk of Second Primary Malignancies for Chronic Myeloid Leukaemia in the French Imatinib-based SPIRIT Trial
Imatinib is a tyrosine kinase inhibitor that has improved the prognosis of patients with chronic myeloid leukemia (CML). CML has become a chronic disease requiring long-term administration of imatinib.
- Trial name
- K2SPIRIT (NCT06646978)
- Testing
- Imatinib (STI571)
- Where
- France
- Volunteers
- 787 people
- Sponsor
- Poitiers University Hospital
Hepatocellular Carcinomas, Cholecystectomy, Laparoscopic
A Multicenter Prospective Observational Study of Computer-aided Risk Perception and Prognosis Prediction in the Whole Process of Laparoscopic Hepatobiliary and Pancreatic Surgery
Artificial intelligence technology is used to realize high-quality 3D scene reconstruction, whole process segmentation, scene activity understanding for common surgery guidance in hepatobiliary surgery, as well as intelligent…
- Conditions
- Hepatocellular Carcinomas, Cholecystectomy, Laparoscopic, Hepatectomy, Pancreatoduodenectomy
- Trial name
- NCT06647264
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Multiple Sclerosis, Epilepsy
Psychometric Evaluation in Patients With Brain Damage During Neuroinflammation
The presence of a damage to the central and / or peripheral nervous system resulting from diseases of a different nature (such as, Multiple Sclerosis, Parkinson's disease, dementia, head trauma, stroke, epilepsy or other…
- Conditions
- Multiple Sclerosis, Epilepsy, Parkinson Disease, Dementia
- Trial name
- NCT05450237
- Testing
- Psychometric Evaluations
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Neuromed IRCCS
Stroke, Ischemic
Antithrombotic Therapy With Regulation of Blood Pressure in Non-Cardioembolic Progressive Stroke
Stroke has become the leading cause of death in China, with acute ischemic stroke still progressing within one week of onset, known as progressive ischemic stroke (PIS), which has a high rate of disability and mortality…
- Trial name
- NCT06551727
- Testing
- Intervention group, Control group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Ruijin Hospital
Dental Implants, Immediate Implant Soft Tissue Healing
Effectiveness of ALB-PRF With Two Types of Bone Grafts With Putty Form Around Immediate Dental Implants.
The goals of this clinical trial study is to evaluate the additive effect, of using ALB-PRF membrane combined with two different types of bone grafts with putty form in treatment of peri-implant bony defects around immediate…
- Conditions
- Dental Implants, Immediate Implant Soft Tissue Healing, Immediate Implant With Bone Graft
- Trial name
- ALB-PRFE-PRF (NCT06643468)
- Testing
- participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen membrane., participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and ALB- PRF as membrane., participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and collagen membrane.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Blood Glucose Concentration, Blood Glucose Self Monitoring
Effect of Low Water Intake on Glucose Regulation Measured Using Continuous Glucose Monitoring
This clinical trial aims to learn if increasing water intake for five days can lower blood glucose in healthy, free-living individuals.
- Trial name
- NCT06645431
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
NSCLC, Stage I
Comparison of Sublobar and Lobectomy in Small (2 Cm or Less 0.5<CTR<1) Non-small Cell Lung Cancer: a Prospective, Multicenter Randomized Controlled Study
The early NSCLC（Non-small cell lung cancer） patients with partial solid nodules mainly composed of solid components, whose maximum tumor diameter was ≤ 2.0cm and 0.5<CTR（Consolidation tumor ratio）<1, as indicated by preoperative…
- Trial name
- NCT06028412
- Testing
- Sublobar, Lobectomy
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Xiaolong Yan, Dr.
Achilles Tendon Rupture, Achilles Tendon Surgery
Endoscopic Flexor Hallucis Longus Transfer vs Minimally Invasive Repair in Acute Achilles Tendon Rupture
The goal of this observational study is to compare the outcomes of two different surgical techniques (Endoscopic Flexor Hallucis Longus transfer - Group 1 vs Minimally Invasive primary repair - Group 2) for patients with acute…
- Conditions
- Achilles Tendon Rupture, Achilles Tendon Surgery, Achilles Tendon Injury
- Trial name
- NCT06114368
- Testing
- Surgery for the treatment of Acute Achilles tendon rupture
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Abdominal Obesity, Cardiac Disease
Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters
The study aims to evaluate the impact of different dietary interventions on body composition (abdominal fat components and quadriceps muscles) and cardiometabolic parameters.
- Conditions
- Abdominal Obesity, Cardiac Disease, Metabolic Disease, Cardiometabolic Syndrome
- Trial name
- NCT06320782
- Testing
- Calorie restriction and balanced distribution of macronutrients, Calorie restriction and low-carbohydrate diet, Calorie restriction and low-fat diet
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
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