Clinical trials: unknown status
Relapsed or Refractory Multiple Myeloma
YTS104 Cell Injection for the Treatment of Relapsed or Refractory Multiple Myeloma
This is a single-center, single-arm, open-label phase I clinical study to determine the safety and efficacy of relapsed or refractory multiple myeloma subjects
- Trial name
- NCT05913804
- Testing
- YTS104 Cells injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Initial Dental Caries, White Spot Lesion of Tooth
Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment
To evaluate and compare the clinical effect of four different remineralizing agents on initial enamel caries after a two years follow up.
- Trial name
- NCT07111403
- Testing
- SAP fluoride plus, 10% n-HAp., 10% n-BAG.
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Pain, Postoperative
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
Moderate to severe postoperative pain is relatively common after major abdominal surgery. It is associated with less than optimal surgical experience, poor quality of recovery, and the development of persistent postsurgical pain.
- Trial name
- NCT06387303
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Acute Ischemic Stroke
Ali Pay Intelligent Navigation Applet-aided Pre-hospital Triage for Non-emergency Medical Service Patients With Acute Ischemic Stroke
According to the Bigdata Observatory platform for Stroke of China (BOSC), the proportion of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis or endovascular treatment in China is 5.64% and 1.45%…
- Trial name
- i-Path (NCT06613074)
- Testing
- Ali Pay intelligent navigation applet
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Perineum; Wound
Postnatal Perineal Wound Assessment
Around 85% of women who give birth vaginally experience a perineal wound, which could be a tear or an incision between the vaginal opening and the anus.
- Trial name
- NCT06551493
- Testing
- Observation of postnatal wound assessment, Interview
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Metastatic Pancreatic Adenocarcinoma
Vitamin C to Chemotherapy Related Anemia in Pancreatic Cancer
The purpose of this study is to evaluate the efficacy of low-dose vitamin C on improving the quality of life for metastatic pancreatic cancer patients receiving gemcitabine and nab-paclitaxel chemotherapy.
- Trial name
- PTCA199-3 (NCT06018883)
- Testing
- Ascorbate, Nab paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Myopia, Progressive, Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression
This is a monocenter, randomized, controlled, parallel-group, double-masked clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation at baseline compared to a…
- Trial name
- NCT05331378
- Testing
- Test myopia control lenses, Single vision lenses
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Essilor International
Advanced Solid Tumors
Study of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumors.
A Phase I Study of Dose Escalation and Dose Expansion To Evaluate the Safety、Tolerability、Pharmacokinetics and Preliminary Efficacy of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumor.
- Trial name
- NCT04778839
- Testing
- Paclitaxel Micelles for Injection, Paclitaxel injection
- Where
- China
- Volunteers
- 98 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Coronary Artery Disease, Systemic Inflammatory Response Syndrome
A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG
A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive…
- Conditions
- Coronary Artery Disease, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- NCT07101367
- Testing
- Normal saline, Dexmedetomidine, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulmonary Complication, Post Operative Complication
Lung Ultrasound Score as Post Operative Predictive Value of Pulmonary Complications in Living Liver Transplant Recipient
The aim of this study is to determine if lung ultrasound score has a strong predictive value for post operative pulmonary complications in living liver transplant recipient
- Trial name
- NCT06498895
- Testing
- lung ultrasound
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
Malformation, Female Infertility
Surgical and Obstetric Outcomes in Patients With Uterine Malformations Undergoing Hysteroscopic Corrective Treatment
The goal of this observational cohort study is to learn if hysteroscopic correction can improve reproductive outcomes in women with uterine malformations.
- Conditions
- Malformation, Female Infertility, Hysteroscopy Surgery
- Trial name
- MAL_CO (NCT06610864)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Antiphospholipid Syndrome, Thrombocytopenia
Anti-CD38 Antibody Treating APS With Thrombocytopenia
To evaluate the safety and efficacy of anti-CD38 antibody in the treatment of antiphospholipid syndrome with secondary thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment and at…
- Trial name
- NCT05983952
- Testing
- Anti-CD38 antibody Injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Solid Tumour Refractory to Conventional Treatment
Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid Tumours
This study will investigate the use of a new drug targeting the DNA repair pathway AZD6738, an ATR inhibitor). Many tumours have lost important DNA repair functions and rely more heavily on a few remaining repair pathways to…
- Trial name
- Patriot (NCT02223923)
- Testing
- AZD6738, Palliative radiotherapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 87 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Myasthenia Gravis, Generalized
Rituximab EfFicacy IN MyasthEnia Gravis (REFINE)
The primary objective of this phase III trial is to investigate if Rituximab can reduce patients' functional impairment caused by MG.
- Trial name
- REFINE (NCT05868837)
- Testing
- Rituximab
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anxiety, Healthcare Disparity
We Will Compare Anxiety Levels Between English and Spanish-speaking Patients Before Surgery at a Children's Hospital. We Hypothesize That Spanish-speaking Patients Will Experience Greater Anxiety, so an Educational Intervention Will be Introduced One-week Before Surgery.
The goal of this trial is to first evaluate whether a difference exists in anxiety scores between Spanish-speaking children and English-speaking children in the pre-operative setting in our patient population as assessed by the…
- Trial name
- NCT06624410
- Testing
- Educational Intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intraepithelial Neoplasia, Cervical Cancer
NWRD09 for HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer
This is a single-arm, open label, two cohorts, multi-center clinical study to evaluate the safety and efficacy of HPV-16 targeted mRNA vaccine (NWRD09) in HPV-16 related Cervical, vaginal, and vulvar intraepithelial neoplasia…
- Trial name
- NCT07092007
- Testing
- NWRD09 administered by intramuscular injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Newish Technology (Beijing) Co., Ltd.
Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
Efficacy of Auricular Acupuncture Therapy in the Prevention of CIPN in Breast Cancer
Evaluate the Efficacy of Auricular Acupuncture Therapy via the Seirin Pyonex Needles in the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
- Trial name
- NCT07092111
- Testing
- Auricular acupuncture treatment
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Malignant Tumor of Digestive Tract, Risk Factors
Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors
Gastrointestinal tumors (esophageal cancer, gastric cancer, colorectal cancer) seriously threaten human health, with a high incidence rate and cancer related hope mortality.
- Trial name
- NCT06118437
- Where
- China
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Prostate CA
Prostate Cancer Care Disparity Analysis Project (ProGAP)
This international cross-sectional study seeks to evaluate global disparities in prostate cancer management by conducting a thorough comparison of key elements across countries categorized as low-income, lower-middle-income…
- Trial name
- NCT06612034
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ankara University
Pancreatic Cancer, Microbiota
Characteristics of Intestinal Microbiome Following Pancreatic Surgery
The goal of this observational study is to learn about intestinal microbiome structure and function in individuals who have undergone a pancreatoduodenectomy and compare to healthy matched controls.
- Conditions
- Pancreatic Cancer, Microbiota, Pancreatoduodenectomy
- Trial name
- NCT06319755
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royal Prince Alfred Hospital, Sydney, Australia