Clinical trials: Phase 4, completed
Pain, Postoperative
Magnesium as an Adjuvant Agent for Postoperative Pain
Participants are being asked to participate in this research study because they have elected to undergo periacetabular osteotomy (PAO).
- Trial name
- NCT05947760
- Testing
- IV Magnesium Sulfate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University Hospitals Cleveland Medical Center
Helicobacter Pylori Infection, Dyspepsia
Vonoprazan-based Versus Esomeprazole-based Triple Therapy for Helicobacter Pylori Eradication
The goal of this clinical trial is to compare the efficacy and safety of vonoprazan-based levofloxacin-containing triple therapy with esomeprazole-based levofloxacin-containing triple therapy for eradication of Helicobacter…
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Peptic Ulcer Disease, Helicobacter Pylori
- Trial name
- NCT07537634
- Testing
- vonoprazan-based triple therapy (VAL regimen), Esomeprazole-based triple therapy (EAL regimen)
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Pain, Postoperative, Developmental Dysplasia of the Hip
Intravenous Dexamethasone to Prolong Caudal Block Analgesia in Children Undergoing Hip Surgery
The goal of this clinical trial is to learn whether a single intravenous dose of dexamethasone prolongs postoperative analgesia after a caudal block in children aged 6 months to 9 years undergoing surgery for developmental…
- Trial name
- DEXA-CAUDAL (NCT07896304)
- Testing
- Dexamethasone, Normal Saline, Caudal Block Anesthesia
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- National Institute of Neurology, Tunisia
Surgery, Incision, Surgical
Prevena Spine for Use in Spine Surgery
A pilot, prospective, single-center study for the investigation of the use of Prevena Vacuum-Assisted Closure devices in patients undergoing spine surgery.
- Trial name
- NCT05555355
- Testing
- Prevena Plus 125 Therapy Unit, Spine surgery
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postoperative Pain, Caesarean Section
Intraperitoneal Hydrocortisone for Postoperative Pain and CRP Following Caesarean Section
The purpose of this study is to evaluate the clinical efficacy of intraperitoneal hydrocortisone 100 mg administration in reducing postoperative pain and inflammatory response in patients undergoing elective Caesarean section…
- Conditions
- Postoperative Pain, Caesarean Section, Peritoneal Inflammation
- Trial name
- NCT07892547
- Testing
- hydrocortisone, Nornal Saline
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Raditsya Mada Gautama, MD
Hip Fractures
What Laxative Should be Used After Hip Fracture Surgery?
To conduct a randomized clinical trial to determine how best to prevent constipation after hip fracture surgery using laxatives.
- Trial name
- NCT06455813
- Testing
- Bisacodyl, Macrogol 3350 and electrolytes, A combination of macrogol 3350 and electrolytes and bisacodyl
- Where
- 2 sites in Denmark
- Volunteers
- 375 people
- Sponsor
- Odense University Hospital
Neutropenia, Febrile
Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia
The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who…
- Trial name
- SAFE (NCT05926063)
- Testing
- Comparison short vs extended EBAT treatment group
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcoma, Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study
A parallel-group randomized pilot trial at a single institution (Duke University) on the effect of postoperative hyperbaric oxygen therapy on wound healing in patients with soft tissue sarcoma undergoing surgical resection with…
- Trial name
- NCT03144206
- Testing
- Hyperbaric oxygen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Spinal Muscular Atrophy
Long-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
A multi-center, longitudinal, prospective, non-comparative study to investigate the long-term safety and effectiveness of risdiplam, prescribed based on clinician judgment as per the Evrysdi® U.S.
- Trial name
- WeSMA (NCT05232929)
- Testing
- Risdiplam
- Where
- 38 sites in United States, Puerto Rico
- Volunteers
- 403 people
- Sponsor
- Genentech, Inc.
Pain, Postoperative
Dose Response Study of Dexmedetomidine in Orthopaedic Spine Surgery Patients
To study the multimodal protocol combining adjunct dexmedetomidine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoserespDex (NCT02454881)
- Testing
- Dexmedetomidine, Oxycodone
- Where
- Finland
- Volunteers
- 107 people
- Sponsor
- Turku University Hospital
Demodex Blepharitis
Demodex Blepharitis in Scleral Lens Wearers
The purpose of this study will be to see if Xdemvy (lotilaner ophthalmic solution) 0.25% has a positive impact on ocular surface symptoms and PROSE device functionality and performance.
- Trial name
- NCT07561450
- Testing
- Xdemvy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Boston Sight
Community-acquired Pneumonia
The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)
The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice.
- Trial name
- CAP-D (NCT06295120)
- Testing
- Phenoxymethylpenicillin 1.2 MIE 4 times daily
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Research Unit for General Practice in Aalborg
Resistant Hypertension, Kidney Failure, Chronic
Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension
Many patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on…
- Conditions
- Resistant Hypertension, Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07888504
- Testing
- Spironolactone
- Where
- Indonesia
- Volunteers
- 21 people
- Sponsor
- Universitas Sebelas Maret
Metastatic Colorectal Carcinoma
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer
The aim of this work is to assess the antitumor effect of Pentoxiphylline in patients with metastatic colorectal cancer receiving stomatal chemotherapy ± targeted therapy.
- Trial name
- CRC - PTX (NCT06115174)
- Testing
- Pentoxifylline, FOLFOX, XELOX
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Naso-Orbito-Ethmoidal, Fractures
REDUCTION ACCURACY IN NASO-ORBITO-ETHMOIDAL FRACTURES AFTER VIRTUAL REDUCTION AND FIXATION USING PRE-ADAPTED MINIPLATES
This study aims to assess the reduction accuracy of Naso-orbito-ethmoidal (NOE) fractures using pre-adapted titanium miniplates based on a virtually reduced 3D model.
- Trial name
- NCT07791095
- Testing
- pre-adapted titanium miniplates based on a virtually reduced 3D model
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Alexandria University
Venous Thromboembolism
Comparison of Bleeding Risk Between Rivaroxaban and Apixaban: The Pilot Study
This vanguard pilot study compares rivaroxaban and apixaban, two of the new oral blood thinners for the treatment of blood clots. Half of the patients will receive apixaban and half will receive rivaroxaban.
- Trial name
- COBRRA Pilot (NCT02559856)
- Testing
- Apixaban, Rivaroxaban
- Where
- 4 sites in Canada
- Volunteers
- 71 people
- Sponsor
- Ottawa Hospital Research Institute
Cerebral Infarction
Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke
This study is randomized, Sodium Ozagrel (Thromboxane A2 Synthase Inhibitor) controlled study on acute ischemic stroke. The primary endpoints were the rate of patients with modified Rankin Scale score of 0-1 at 3 months.
- Trial name
- NCT00200356
- Testing
- Edaravone, Sodium Ozagrel
- Volunteers
- 401 people
- Sponsor
- Shionogi
Postmenopausal Osteoporosis
A Study of Romosozumab (EVENITY®) in Postmenopausal Women in India With Osteoporosis at a High Risk of Fracture.
The primary objective of this study is to characterize safety and tolerability of romosozumab in postmenopausal women with osteoporosis and a high risk of fracture in India.
- Trial name
- NCT06079476
- Testing
- Romosozumab
- Where
- 10 sites in India
- Volunteers
- 100 people
- Sponsor
- Amgen
Cesarean Delivery
Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery
The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg)…
- Trial name
- NCT06826742
- Testing
- Intravenous line (IV) Methadone, Intrathecal Morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic