Clinical trials: Early Phase 1, completed
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT04587791
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Crohn Disease (CD), Crohn Disease
Cranberry and Gut Health in Crohn's Disease
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease.
- Trial name
- NCT07170462
- Testing
- Cranberry powder
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ana Maldonado-Contreras
Major Depressive Disorder, Bipolar Depression
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression.
- Trial name
- NCT03748446
- Testing
- Xenon, Nitrogen gas
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Brain Mapping
Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness
Background: The glymphatic system helps keep harmful waste from building up in the brain. Researchers think it is more active in people during sleep than while awake.
- Trial name
- NCT02311374
- Testing
- Brain connectivity and physiology, Brain Wave
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Reliability of the Human Brain Connectome
Background: Magnetic resonance imaging (MRI) is used to investigate brain function. Researchers want to use MRI to better understand the function patterns and connections between brain regions in healthy people.
- Trial name
- NCT02193425
- Testing
- F-18FDG, MRI
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mesenchymal Stromal Cells, Cornea
Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops.
- Conditions
- Mesenchymal Stromal Cells, Cornea, Corneal Defect, Corneal Epithelium Defect
- Trial name
- MSC Secretome (NCT05204329)
- Testing
- MSC Secretome Eye Drops
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois at Chicago
Benign Paroxismal Positional Vertigo
BPPV Recurrence After CRM With & Without Supplementation
Benign paroxysmal positional vertigo (BPPV) may frequently recur even after successful canalith repositioning maneuvers (CRMs). This study investigates whether the addition of vitamin K₂ to vitamin D₃ offers additional benefits…
- Trial name
- RR-BPPV-DK (NCT07861464)
- Testing
- Combined vitamin D₃ and K₂ supplementation, Vitamin D₃ alone, Canalith repositioning maneuver (CRM) alone
- Where
- Jordan
- Volunteers
- 404 people
- Sponsor
- University of Jordan
Carcinoma of the Anal Canal
Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma
This research study is a Pilot Study. Pilot studies are conducted to see if it is practical to do this type of research ona larger scale in the future.
- Trial name
- NCT01858025
- Testing
- Pencil Beam scanning Radiation, 5-fluorouracil, Mitomycin-C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder
Dexamethasone to Target Stress and Immune System Mechanisms Underlying Alcohol Craving
This is a double-blind, placebo-controlled, proof of concept laboratory study to recruit N=70 (35 Males / 35 Females) non-treatment seeking, heavy drinkers with alcohol use disorder (AUD).
- Trial name
- NCT05305404
- Testing
- Dexamethasone Oral
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stony Brook University
Dengue
Immunogenicity of an Intradermal Qdenga Vaccine Among Healthy Volunteers
Official title: Immunogenicity of an intradermal Qdenga vaccine among healthy volunteers: A pilot study
- Trial name
- NCT06837116
- Testing
- Vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck
Pilot Study of Imatinib Cetuximab Combo for H & N Cancer
The goal of this clinical trial is to find if levels of a protein called AXL in tumor cells relate to how tumors respond to cetuximab (CTX) combined with imatinib in participants with head and neck cancer.
- Trial name
- NCT05816785
- Testing
- Cetuximab, Imatinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Multiple Sclerosis
Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis
The goal of this pilot study is to determine whether fecal microbial transplant (FMT) has the potential to be an effective, safe and tolerable therapy for the treatment of multiple sclerosis (MS).
- Trial name
- NCT04096443
- Testing
- Fecal microbial transplant (FMT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Griffin Hospital
Bacterial Vaginosis
Impact of Clinician-administered Vaginal Live Biotherapeutic Product
This is an open-label, single-arm, Phase Ib trial assessing the consistency of response and colonization kinetics of a vaginally inserted live biotherapeutic intervention with optimized adherence.
- Trial name
- NCT07305844
- Testing
- LC106
- Where
- 2 sites in United States, South Africa
- Volunteers
- 26 people
- Sponsor
- Caroline Mitchell
Skin Basal Cell Carcinoma, Skin Nodular Basal Cell Carcinoma
Intratumoral Injection of Standard Universal Donor Expanded Natural Killer Cells and TGF-beta Imprinted Natural Killer Cells for the Treatment of Skin Squamous Cell Carcinoma and Basal Cell Carcinoma
This early phase I trial compares the safety, side effects and the biological or cellular activity of two types of universal donor (UD) natural killer (NK) cells (standard NK cells and transforming growth factor [TGF] beta…
- Conditions
- Skin Basal Cell Carcinoma, Skin Nodular Basal Cell Carcinoma, Skin Squamous Cell Carcinoma
- Trial name
- NCT07144384
- Testing
- Biopsy Procedure, Natural Killer Cell Therapy, Surgical Procedure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy Volunteer
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats.
- Trial name
- K-BREATHE (NCT07220122)
- Testing
- 1,3 butanediol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity
Angiotensin-(1-7) and Energy Expenditure in Human Obesity
The objective of this study is to better define the role of the hormone angiotensin-(1-7) in energy balance. We will test the overall hypothesis that angiotensin-(1-7) increases resting energy expenditure and promotes markers of…
- Trial name
- NCT03777215
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Amy Arnold
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes, Hypercholesterolaemia
The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans
Cardiovascular disease (CVD) is a major and persistent health disparity for African Americans. Linking GAINS is a randomized pilot and feasibility study designed to evaluate whether receiving genetic risk information early in a…
- Conditions
- Diabetes, Hypercholesterolaemia, Hypertension, Obesity Type 2 Diabetes Mellitus
- Trial name
- LINKING GAINS (NCT07833384)
- Testing
- Color Genomics Genetic Testing Panels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Social Cognition
Losartan and Social Processing
This study explores the effects of single-dose losartan (50mg) versus placebo on social processing in healthy volunteers.
- Trial name
- NCT06624904
- Testing
- Losartan potassium 50mg
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Renal Cell Carcinoma
Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma
This is a pilot, single-center, single-arm study where 20 patients with metastatic or unresectable clear cell renal cell carcinoma will receive same sequential treatment strategy (Cabozantinib for 12 weeks, then proceed with…
- Trial name
- NCT05188118
- Testing
- Cabozantinib, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai