Clinical trials: Early Phase 1, completed
Anorexia Nervosa, Obsessive-Compulsive Disorder
Radical Openness for Adolescents Pilot
Heightened performance monitoring and overcontrol (HPM/OC) is characterized by inflexibility, a need for control, perfectionism, anxious apprehension and high error monitoring.
- Conditions
- Anorexia Nervosa, Obsessive-Compulsive Disorder, Social Phobia, Depression, Anxiety
- Trial name
- ROA (NCT05913557)
- Testing
- Radically Open Dialectical Behavior Therapy (RO DBT)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Prostatic Neoplasms
Gallium-68 Citrate PET Used in Prostate Cancer
This is a single center, pilot, cross-sectional imaging study investigating the use of gallium-68 citrate PET in participants with metastatic castration-resistant prostate cancer who are planning to undergo a metastatic tumor…
- Trial name
- NCT02391025
- Testing
- Gallium-68 citrate, Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Rahul Aggarwal
Cognitive Change
Sharing History Through Active Reminiscence and Photo-imagery (SHARP) Pilot Program
SHARP is a neighborhood-based and technology-supported approach to brain health for older Black adults that integrates walking and image-prompted social reminiscence to maintain or improve brain health.
- Trial name
- SHARP (NCT05906654)
- Testing
- Sharing History through Active Reminiscence and Photo-imagery (SHARP)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Gastric Cancer (Diagnosis)
Clinical Study of Modified Banxia Xiexin Decoction Treatment on Gastric Cancer
Research purpose To elucidate the effect mechanism and clinical effective of Modified Banxia Xiexin Decoction in the prevention and treatment of gastric cancer.
- Trial name
- NCT05908838
- Testing
- Modified Banxia Xiexin Decoction
- Volunteers
- 146 people
- Sponsor
- ShuGuang Hospital
Cognitive Change
Sharing History Through Active Reminiscence and Photo-imagery - With MCI
The SHARP-MCI study tests impact of walking and social reminiscence on cognitive function, blood pressure, and weight among healthy Black Americans and those experiencing mild cognitive impairment (MCI).
- Trial name
- SHARP-MCI (NCT05906667)
- Testing
- Sharing History through Active Reminiscence and Photo-imagery (SHARP)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Alopecia Areata
Sodium Valproate-loaded Nanospanlastics in Patchy Alopecia Areata in Comparison to Topical Steroids
the aim of this study is to assess the efficacy and safety of sodium valproate-loaded nanospanlastic in the treatment of patchy AA, in comparison to conventional therapy with topical steroids
- Trial name
- NCT05017454
- Testing
- the optimized sodium valproate-loaded nanospanlastic dispersion, mometasone furoate lotion
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Kasr El Aini Hospital
Vitamin D Deficiency
Optimization of Blood Levels of 25(OH)-Vitamin D in African Americans
Two-thirds of the US population, particularly African Americans (AA), is at risk for inadequate or deficient 25-hydroxy-vitamin D (25(OH)VD).
- Trial name
- NCT04939792
- Testing
- Vitamin D, Vitamin D + L-cysteine, L-cysteine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers
This pilot research trial studies the antibody response to high-dose seasonal influenza vaccination in patients with myeloid malignancy receiving chemotherapy and healthy volunteers.
- Trial name
- NCT04484532
- Testing
- Trivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Healthy
Facilitators to Keeping Colonoscopy Appointments
To identify patients at risk for nonattendance to their first scheduled colonoscopy and to conduct a randomized trial of a theory-based, peer coach intervention on completing the scheduled colonoscopy.
- Trial name
- NCT00431327
- Testing
- Peer coach phone call
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Plaque Psoriasis
Comparison of Cyanocobalamin in Avocado Oil Cream With Steroid Combination Ointment
A randomized clinical trial with two groups. Group A Group B Group A is being treated with conventional Steroid combination ointment for the treatment of chronic Plaque Psoriasis.
- Trial name
- NCT05330936
- Testing
- Potent topical steroid
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Healthy Volunteers
A Study in Healthy Participants Investigating Biomarkers After Exposure to Heparin When Heparin is Administered in the Fasted State or After a High-fat Meal. Heparin, a Registered Drug, is an Anticoagulant (Blood Thinner) That Prevents the Formation of Blood Clots.
In this study biomarkers in the blood after exposure to heparin in the fasted state or after a high-fat meal will be investigated.
- Trial name
- NCT05178550
- Testing
- Heparin
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Rift Valley Fever
Safety and Immunogenicity of a Candidate RVFV Vaccine (RVF001)
Phase I open label, non-randomised dose escalation study on healthy UK volunteers aged from 18 to 50 years to assess the safety and immunogenicity of ChAdOx1 RVF
- Trial name
- NCT04754776
- Testing
- ChAdOx1 RVF
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Head and Neck Cancer
A Microdose Evaluation Study of ABY-029 in Head and Neck Oncology Surgery
The primary study objective is to determine if microdoses of ABY-029 (up to 6X) lead to detectable signals (defined as signal-to-noise ratio, SNR ≥10, with wide-field iFI) in sampled tissues with an EGFR (epidermal growth factor…
- Trial name
- NCT03282461
- Testing
- ABY-029
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Deep Vein Thrombosis, Pulmonary Embolism
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin
The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT03516656
- Testing
- Standard heparin dose, Real time heparin dose adjustment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Healthy
Cannabidiol and Autonomic Function at Rest
Cannabidiol (CBD) is one of 700 chemicals derived from the Cannabis sativa plant and is both legal and widespread for distribution in the state of Vermont.
- Trial name
- NCT04731779
- Testing
- cannabidiol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Castleton University
Smoking Cessation
Applying mHealth to Tobacco-related Health Disparities
The purpose of this study is to better understand what happens when someone attempts to quit smoking.
- Trial name
- Time2Quit (NCT03404596)
- Testing
- Nicotine Patch, Counseling, Smartphone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pain
LIA in Hip Arthroscopy Patients
The investigator's are conducting a randomized, blinded study to determine if the extra-capsular local infiltration analgesic (LIA) administration of 20ml 0.25% bupivacaine-epinephrine can improve the postoperative pain…
- Trial name
- NCT03070054
- Testing
- 20ml 0.25% bupivacaine-epinephrine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Utah
Post Traumatic Stress Disorder
Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury
A pilot study to evaluate feasibility for a full-scale merit application. Specifically, for veterans considering prolonged exposure (PE) therapy, following the model established by Foa et al, we need to establish safety, and…
- Trial name
- NCT04280965
- Testing
- Quetiapine Fumarate, Standard of care meducations
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Endothelial Dysfunction, Obesity
Leptin Infusion and Endothelial Vasomotor Response
Adipose tissue is an active endocrine organ producing several hormones with circulatory and metabolic effects. In 1994, the hormone leptin was discovered.
- Conditions
- Endothelial Dysfunction, Obesity, Vasodilation, Venous Occlusion Plethysmography
- Trial name
- LIVARM (NCT04374500)
- Testing
- Leptin infusion plus vasodilators in healthy men, Leptin infusion in healthy men, Vasodilators in CAD patients
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stefan Soderberg
Type 1 Diabetes
Targeting Beta Cell Dysfunction With Verapamil in Longstanding T1D
The purpose of this study is to determine whether verapamil can transiently improve beta cell function in those who do or do not secrete proinsulin and little/no C-peptide.
- Trial name
- NCT05847413
- Testing
- Verapamil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Benaroya Research Institute