Clinical trials: sponsored by Yale University
Diabetes Mellitus, Type 2
Adolescent-mediated Family Diabetes Intervention: American Samoa
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of an adolescent-mediated intervention designed to improve the glycemic control and self-care practices of a parent/grandparent.
- Trial name
- NCT05356884
- Testing
- Diabetes Intervention, Leadership & Life Skills
- Where
- American Samoa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Yale University
Borderline Personality Disorder
MDMA in Borderline Personality Disorder
The purpose of this study is to test the effects of MDMA (3,4-methylenedioxymethamphetamine) on social cognition in adults with Borderline Personality Disorder.
- Trial name
- MDMA in BPD (NCT06683014)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT07886606
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Pain, Pituitary Surgery
Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery
This study is testing whether oxytocin can help lessen pain by changing how people process emotions and social experiences. The goal is to better understand how the brain links emotions, relationships, and pain, and whether this…
- Trial name
- NCT07730294
- Testing
- Oxytocin (Low dose), Oxytocin (High dose)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Epilepsy, Seizures
BHV-7000 Responsive Neurostimulation System (RNS) Study
This is an open label study to assess the biological effect of BHV-7000 on abnormal activity recorded by the RNS System in patients with focal epilepsy implanted with the RNS System.
- Trial name
- NCT07125261
- Testing
- BHV-700
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Severe Mental Illness, Hospitalizations Psychiatric
Community-Based Intensive Treatment (CBIT): Meeting the Complex Needs of Rural Adults With Serious Mental Illness
The purpose for this research project is to successfully achieve the primary systems intervention outcome, maintaining fidelity to the intervention model and time to rehospitalization.
- Conditions
- Severe Mental Illness, Hospitalizations Psychiatric, Rural Healthcare-seeking Behaviour, Rural Health
- Trial name
- CBIT (NCT07887113)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Cannabis Use
SV2A in Older Adults
The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using [11C]UCB-J PET imaging.
- Trial name
- NCT05465538
- Testing
- [11C]UCB-J PET
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Substance Use Disorders
Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)
This study seeks to compare the effectiveness of two Patient Navigation models of care to evaluate the proportion who initiate PrEP/ART and substance use/substance use disorder (SU/SUD) treatment.
- Trial name
- NCT07223398
- Testing
- Standard PN, Patient Choice
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Yale University
Mental Health Issue, COVID-19
Evaluating the Impact of Social Music
Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing.
- Trial name
- NCT06513910
- Testing
- Music
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health Issue, COVID-19
Evaluating the Community Drum Circle
Mental health vulnerability due to stress is increased America due to disproportionate effects of social factors such as racism, poverty, education, and criminal justice sentencing.
- Trial name
- NCT06513858
- Testing
- Communal Drumming, Communal drumming recordings
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yale University
Perioperative/Postoperative Complications, Aerobic Capacity
SHAPE Test for Preoperative Risk Stratification
This study is looking at whether a simplified exercise test called the SHAPE-HF cardiopulmonary testing system can be used before surgery in older adults.
- Trial name
- SHAPEPAT (NCT05743673)
- Testing
- Shape II
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health Issue, COVID-19
Music Mindfulness Study 2a.
Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing.
- Trial name
- NCT06505226
- Testing
- in person meditation, in person meditation using headphones, virtual meditation
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Yale University
Borderline Personality Disorder
Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline…
- Trial name
- MIND-BPD (NCT06446765)
- Testing
- mindfulness-based Neurofeedback, control Neurofeedback
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Yale University
Mental Health Issue, COVID-19
Drum Circle Synchrony Study 2c.a.
Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing.
- Trial name
- NCT06513845
- Testing
- Communal drumming recordings
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health Issue, COVID-19
Evaluating Social Perception Dynamics
Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing.
- Trial name
- NCT06513871
- Testing
- Social perception tasks
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer Disease, Dementia
Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers
This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver
- Trial name
- NCT06940687
- Testing
- Pre-recorded Music Session, Live Music Session
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Obsessive-Compulsive Disorder
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
This study aims to investigate the effects of oral psilocybin on OCD symptomatology and provide the first evidence of the neural mechanism that may mediate psilocybin's purported therapeutic effects on OCD.
- Trial name
- NCT03356483
- Testing
- Psilocybin (0.25mg/kg), Niacin (250mg)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder
Expanding Medication-Assisted Therapies in Central Asia
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the…
- Trial name
- ExMAT CA (NCT05579470)
- Testing
- NIATx
- Where
- 4 sites in United States, Kazakhstan and 2 more
- Volunteers
- 900 people
- Sponsor
- Yale University
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