Clinical trials: open to volunteers, sponsored by VA Office of Research and Development
Post SARS-CoV2 (COVID-19)
Home-Based Exercise Tele-Rehabilitation After COVID-19
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery.
- Trial name
- BOOST (NCT05425264)
- Testing
- Tele-exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Sleep Initiation and Maintenance Disorders
A Transdiagnostic Sleep Health Intervention for Veterans With PTSD
Sleep disturbance is a major problem in Veterans with posttraumatic stress disorder (PTSD). This study will test a version of a sleep treatment that's been shown to be effective in the general population, with some changes to…
- Trial name
- NCT06549049
- Testing
- TranS-C for PTSD, Sleep Psychoeducation Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
DRonabinol Treatment of OSA
This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks.
- Trial name
- DROSA (NCT06477952)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
NAFLD, MASLD
NAFLD Clinical Care Pathway
Non-alcoholic fatty liver disease (NAFLD) is a new condition that has become the most common chronic liver disease in the world and a main cause of liver cirrhosis, liver failure and liver cancer.
- Trial name
- NCCP (NCT06671886)
- Testing
- E-trigger
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Insomnia, PTSD
The Effects of Orexin Antagonism on Fear Extinction in PTSD
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased…
- Trial name
- NCT06788522
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 40,120 people
- Sponsor
- VA Office of Research and Development
Schizophrenia Spectrum Disorders, Psychotic Affective Disorders
MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI
This study aims to test the feasibility and acceptability of a brief behavioral intervention that combines two treatments, Motivational Interviewing (MI) and Cognitive Behavioral Therapy (CBT), that have been shown to work in…
- Conditions
- Schizophrenia Spectrum Disorders, Psychotic Affective Disorders, Psychotic Mood Disorders, Homelessness
- Trial name
- NCT06138054
- Testing
- MI-CBTech, Mindfulness control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Basal Cell Carcinoma
Basal Cell Carcinoma Chemoprevention Trial
This is an intent-to-treat, parallel design, multicenter randomized trial and the primary intervention is a double-blind comparison of imiquimod (IMQ) vs.
- Trial name
- B3C (NCT05212246)
- Testing
- 5% Imiquimod cream
- Where
- 8 sites in United States
- Volunteers
- 1,630 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee
Boosting Exercise Adherence in Knee Osteoarthritis
This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise among Veterans receiving physical therapy (PT) for…
- Trial name
- BOOST-OA (NCT07219732)
- Testing
- Usual PT Care (UC), BOOST-OA
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
COVID-19, SARS-CoV-2 Infection, RSV
Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)
The purpose of this study is to comprehensively describe the temporal and geographic utilization of COVID-19 therapies used for mild to moderate disease during different periods of SARS-CoV-2 variant circulation as well as to…
- Conditions
- COVID-19, SARS-CoV-2 Infection, RSV, Influenza
- Trial name
- COPE-VA (NCT06160128)
- Where
- United States
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Kidney Injury (AKI)
Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney Injury
Acute kidney injury (AKI) affects up to 20% of hospitalized Veterans and is strongly associated with morbidity and death. AKI is a diverse condition and timely and accurate diagnosis of the type of AKI is critical to begin…
- Trial name
- PRECISE-AKI (NCT07217808)
- Testing
- PRECISE-AKI Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Hypercholesterolemia
Pharmacogenomic Informed Statin Prescribing
Statins are the most cost-effective medications to lower cholesterol and cardiovascular disease (CVD) risk. However, many patients at high-risk for CVD do not accept or adhere to statins.
- Trial name
- NCT06568601
- Testing
- Pharmacogenetic and polygenic risk testing, Active control
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- VA Office of Research and Development
Alcohol Problems, Post-Traumatic Stress Disorder
The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans
Veterans seeking to improve their romantic relationships when high conflict and unhealthy dynamics (e.g., aggression) are present remain underserved within the VHA with few treatment options.
- Trial name
- ACT-SHARE (NCT06746727)
- Testing
- Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Metastatic Non-Small Cell Lung Cancer, Cancer-Associated Weight Loss
Tocilizumab Combined With First-Line Chemo-Immunotherapy in Metastatic Non-Small Cell Lung Cancer
This is a Phase 1b/2, multi-site, single-arm, open-label, non-randomized study looking at whether adding tocilizumab to standard treatment for metastatic Non-Small Cell Lung Cancer (NSCLC) is safe, possible, and effective.
- Conditions
- Metastatic Non-Small Cell Lung Cancer, Cancer-Associated Weight Loss, Elevated Inflammatory Markers
- Trial name
- TOCI (NCT07889232)
- Testing
- Tocilizumab, Pembrolizumab, Platinum-Doublet Chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- VA Office of Research and Development
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
People who have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) are often treated with ibrutinib, acalabrutinib, or zanubrutinib. These are pills that are taken by mouth.
- Trial name
- Benefit VA (NCT06520098)
- Testing
- Venetoclax, Ibrutinib, Acalabrutinib, Zanubrutinib
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Substance-Related Disorders
RISE for PTSD and Substance Use Disorder in Veterans
Veterans with co-occurring posttraumatic stress disorder (PTSD) and substance use disorder (SUD) experience significant impairment and worse treatment outcomes compared to those with either condition alone, including higher rates…
- Trial name
- RISE (NCT07903753)
- Testing
- Written Exposure Therapy, Cognitive Behavioral Therapy for Substance Use Disorders (skill components), Cognitive Behavioral Therapy for Substance Use Disorders
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
PTSD - Post Traumatic Stress Disorder
Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD
Many Veterans with post-traumatic stress disorder (PTSD) do not fully benefit from the best current treatments, some of which focus on helping the brain regulate trauma memories.
- Trial name
- WET+MPH (NCT07904000)
- Testing
- Written Exposure Therapy (WET), methylphenidate (MPH)
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Salience Network Informed rTMS for PTSD
The proposed study will test whether magnetic resonance imaging (MRI)-guided transcranial magnetic stimulation (TMS) can reduce posttraumatic stress disorder (PTSD) symptoms in Veterans.
- Trial name
- NCT07886840
- Testing
- Active MRI-Guided intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- VA Office of Research and Development
Overactive Bladder, Parkinson Disease
Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease
The purpose of this study is to learn about different treatments for overactive bladder symptoms in Parkinson's Disease. The investigators want to find out if people who do not respond to one treatment (either behavioral or drug…
- Trial name
- SQUARE PD (NCT07187466)
- Testing
- mirabegron, Exercise-based behavioral therapy
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- VA Office of Research and Development
Chronic Low Back Pain, Musculoskeletal Pain
Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT
The objectives of this VA Merit application are to demonstrate efficacy of combined intermittent theta burst (iTBS) and yoga (iTBS+yoga) intervention on improving pain, function, analgesic use, self-efficacy, quality of life and…
- Trial name
- VIBRANT (NCT07158567)
- Testing
- intermittent theta burst stimulation, LoveYourBrain Yoga Program
- Where
- 2 sites in United States
- Volunteers
- 213 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Pressure Injury
Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life.
- Trial name
- CAPP-FIT (NCT06529094)
- Testing
- Provider training, CAPP-FIT intervention with RA facilitation, CAPP-FIT implementation during maintenance phase
- Where
- 8 sites in United States
- Volunteers
- 808 people
- Sponsor
- VA Office of Research and Development