Clinical trials: completed, sponsored by VA Office of Research and Development
Pressure Ulcer
CMAP Refinement for Pressure Injury Prevention
For Veterans with spinal cord injury who use a wheelchair, pressure injuries related to sitting are a significant daily threat to well-being.
- Trial name
- NCT04309864
- Testing
- Use of CMAP app for education (in-hospital), Use of CMAP app (in-home)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Safety Aid Reduction Treatment for PTSD Among Veterans
The purpose of this project is to examine the acceptability, feasibility, and utility of a safety aid reduction treatment (START) among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- START-PTSD (NCT04515784)
- Testing
- Safety Aid Reduction Treatment for PTSD
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
HIV Infection
Functional Interval Training for Veterans Exercising Through Telehealth.
Most Veterans living with HIV are 50 years of age or older and can expect to live more than 20 years longer with HIV medication.
- Trial name
- FIT-VET (NCT04103593)
- Testing
- exercise training
- Where
- 3 sites in United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
HIV
Strength Training and Endurance Exercise for LIFE
Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA.
- Trial name
- STEEL (NCT02101060)
- Testing
- exercise
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI
The most persistent and disabling postconcussive symptoms following mild traumatic brain injury (mTBI) are sleep disturbances and cognitive dysfunction, with few tractable interventions currently available.
- Trial name
- SmART-TBI (NCT04603443)
- Testing
- Branched Chain Amino Acids, Protein Control
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- VA Office of Research and Development
Malnutrition, Nutritional Risk
Nutritional Perihabilitation in Older Veterans Undergoing Surgery
This research study will be conducted in two parts. The first part will consist of selecting appropriate screening and assessment tools for Veterans undergoing elective surgery and identifying the number of Veterans who are…
- Conditions
- Malnutrition, Nutritional Risk, Abdominal Surgery
- Trial name
- NCT03073811
- Testing
- Protein enhanced nutrition intervention, Education Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Frailty, Sarcopenic Obesity
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
The continuing increase in prevalence of obesity in older adults including many older Veterans has become a major health concern.
- Conditions
- Frailty, Sarcopenic Obesity, Aging
- Trial name
- DEMFOS (NCT04221750)
- Testing
- Lifestyle therapy, Metformin Hydrochloride, Healthy Lifestyle
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Heart Failure
The Re-Prosper HF Study
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System.
- Trial name
- Re-Prosper HF (NCT04551222)
- Testing
- probenecid
- Where
- 5 sites in United States
- Volunteers
- 125 people
- Sponsor
- VA Office of Research and Development
Multiple Chronic Conditions, Decision Making, Shared
Effect of Patient Priorities Care Implementation in Older Veterans With Multiple Chronic Conditions
The investigators will conduct a randomized control trial enrolling 420 older Veterans with multiple chronic conditions receiving primary care at the Michael E.
- Trial name
- PPC (NCT04922320)
- Testing
- Patient Priorities Care, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 437 people
- Sponsor
- VA Office of Research and Development
Male Osteoporosis
Novel Combination Therapy for Osteoporosis in Men
Osteoporotic fractures are a key health problem in older men. Although there are drugs approved to treat osteoporosis in men [bisphosphonates, denosumab, and teriparatide (TPTD) or PTH(1-34)], there is a lack of knowledge on how…
- Trial name
- Osteo-Men (NCT03994172)
- Testing
- Teriparatide or human parathyroid hormone (PTH) 1-34, Cinacalcet, Calcium citrate tablet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Musculoskeletal Pain
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)
The proposed study will test the feasibility and acceptability of an 8-week home-based reciprocal peer support pain self-management intervention (CONNECT) for women Veterans with chronic musculoskeletal pain.
- Trial name
- CONNECT (NCT04229134)
- Testing
- Project CONNECT
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Pain, Stress Disorders, Posttraumatic
Compassion Meditation vs. Health Education for Veterans
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression.
- Conditions
- Chronic Pain, Stress Disorders, Posttraumatic, Depression
- Trial name
- NCT04651296
- Testing
- compassion meditation, health education
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tobacco Dependence, Veterans
Identifying Effective Treatment for Veterans Unwilling to Quit Smoking
This project will generate knowledge about the effectiveness of Enhanced Chronic Care, an intervention designed to enhance treatment use and smoking abstinence in Veterans who are initially unwilling to quit.
- Trial name
- NCT04061720
- Testing
- Enhanced Chronic Care, Standard Care
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- VA Office of Research and Development
Suicide, Firearm Injury
Home Safety Intervention
Access to lethal methods of self-harm such as firearms and medications increases risk for suicide. As such, VA/DoD guidelines for the care of individuals with elevated suicide risk include recommendations that clinicians deliver…
- Conditions
- Suicide, Firearm Injury, Overdose
- Trial name
- HSI (NCT06216327)
- Testing
- household safety intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Neurosteroids for Treatment of PTSD in Veterans
This study seeks to determine if pregnenolone can improve symptoms of PTSD and other symptoms that commonly occur with PTSD in Iraq/Afghanistan-era Veterans. The total study duration for each participant is 10 weeks.
- Trial name
- NCT03799562
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- VA Office of Research and Development
HIV
VA Video Connect in HIV Care
The purpose of this research study is to see how effective the addition of video to home telehealth services is in helping patients with HIV to remain in care, which is vital to management of their illness.
- Trial name
- NCT04055207
- Testing
- VVC
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- VA Office of Research and Development
Long COVID, Cardiorespiratory Fitness
Nitrite Supplementation in Long COVID Patients
Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID.
- Trial name
- NCT05618574
- Testing
- 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Neurogenic Bladder Dysfunction
Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia
Bladder spasms after spinal cord injury (SCI) can result in incontinence, urinary tract infections, kidney damage, trigger dangerous increases in blood pressure and decrease independence and quality of life.
- Trial name
- NCT03472599
- Testing
- Genital Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development