Clinical trials: sponsored by University of Oxford
Liver Cirrhosis, Fatty Liver
Multiparametric MR for Rapid Imaging Assessment of the Liver
The RIAL study aims to investigate whether non-invasive measurement of liver fat, iron content and fibrosis are as accurate as liver biopsy specimens in determining if patients have non-alcoholic fatty liver disease (NAFLD) or…
- Trial name
- RIAL (NCT01543646)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Cardiovascular Disease
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen…
- Trial name
- SEARCH (NCT00124072)
- Testing
- Simvastatin 20 mg daily, Folic acid 2 mg + vitamin B12 1 mg daily, Simvastatin 80 mg daily
- Where
- United Kingdom
- Volunteers
- 12,064 people
- Sponsor
- University of Oxford
Kidney Disease, Chronic
Study of Heart and Renal Protection
The chief aim of SHARP was to determine whether lowering blood LDL cholesterol with simvastatin (20mg) plus ezetimibe (10mg) daily could safely reduce the risk of coronary heart disease, non-hemorrhagic stroke and the need for…
- Trial name
- SHARP (NCT00125593)
- Testing
- Simvastatin 20 mg, Ezetimibe 10mg
- Where
- United Kingdom
- Volunteers
- 9,438 people
- Sponsor
- University of Oxford
Learning, Behaviour
The DHA (Docosahexaenoic Acid) Oxford Learning and Behaviour (DOLAB) Study
The purpose of this study is to determine whether DHA (in a daily dose of 600 mg.) will improve the behaviour and learning of normal children aged 7-9 years in mainstream state schools who are underperforming according to…
- Trial name
- DOLAB (NCT01066182)
- Testing
- DHA (docosahexaenoic acid), Sunflower oil capsules
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- University of Oxford
Healthy Volunteers, Chuvash Polycythaemia
Study of the Effects of Commercial Air Travel on the Lungs
The study hypothesis is that commercial air travel causes an increase in the blood pressure in the lungs (pulmonary artery pressure) that can be clinically relevant.
- Trial name
- NCT01420224
- Testing
- Commercial airline flight
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Influenza
A Study to Assess the Safety and Efficacy of a New Influenza Candidate Vaccine MVA-NP+M1 In Healthy Adults
This is a Phase IIa open label, non placebo controlled, non-randomised controlled challenge study. The primary objective of this study is to assess the safety of a new influenza vaccine, MVA-NP+M1, when administered as a single…
- Trial name
- NCT00993083
- Testing
- MVA-NP+M1
- Where
- 2 sites in United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Education, Empowerment
Questscope Non-Formal Education Impact Study
This randomized controlled trial (RCT) evaluates the effectiveness of Questscope Non-Formal Education (QS NFE) on impacting psychosocial outcomes for out-of-school youth, ages 13-21, in Jordan.
- Conditions
- Education, Empowerment, Self-efficacy
- Trial name
- QSNFEIS (NCT01001286)
- Testing
- Questscope Non-Formal Education
- Where
- 6 sites in Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Dysphoria
Neural Responses and Dysphoria: Modulation by a Pharmacological Probe
This study aims to improve understanding of how people with low mood and negative feelings (known as dysphoric) may be different from people with normal mood and feelings (nondysphoric) when responding to a variety of social and…
- Trial name
- NCT01101685
- Testing
- Escitalopram
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Parkinson's Disease
Ketogenic Diets for Symptoms of Parkinson's Disease
Parkinson's disease is a progressive condition that harms nerve cells of the brain (neurodegeneration). Current treatments for Parkinson's disease (including levodopa and deep brain stimulation) improve certain symptoms but are…
- Trial name
- NCT01364545
- Testing
- Ketone ester drink
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Malaria
A Study of the Safety and Effectiveness of Two New Malaria Vaccines
This study aims to test the safety of two new malaria vaccines AdCh63 MSP1 and MVA MSP1. These vaccines consist of inactivated viruses which have been modified - so they cannot reproduce (replicate) in humans, and also to include…
- Trial name
- NCT01003314
- Testing
- AdCh63-MSP1 (lower dose) vaccine and MVA-MSP1 vaccine, AdCh63-MSP1 vaccine (higher dose) and MVA-MSP1 vaccine followed by challenge
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis, HIV Infections
The Safety and Immunogenicity of a TB Vaccine; MVA85A, in Healthy Volunteers Who Are Infected With HIV
This study is designed to evaluate the safety of MVA85A in healthy volunteers in the UK who are infected with HIV. In phase I studies, a single vaccination with MVA85A, when administered at a dose of 5 x 10^7pfu intradermally…
- Trial name
- NCT00395720
- Testing
- MVA85A (TB vaccine), MVA 85A
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Study of AdCh63 AMA1 Alone and With MVA AMA1
This is an open label phase I study, to assess the safety of a novel malaria vaccine, AdCh63 AMA1, simian adenovirus encoding Plasmodium falciparum blood stage antigen, Apical Membrane Antigen -1.
- Trial name
- NCT01095055
- Testing
- AdCh63 AMA1, AdCh63 AMa1 and MVA AMA1
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Safety of Tuberculosis Vaccine, MVA85A, Administered by the Intramuscular Route and the Intradermal Route
This is a phase I study that will compare the safety and immunogenicity of candidate tuberculosis (TB) vaccine MVA85A administered by the intramuscular route and the intradermal route in healthy adult individuals who have been…
- Trial name
- NCT01181856
- Testing
- MVA 85A
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
A Phase I Study of a New Tuberculosis (TB) Vaccine, MVA85A, in Healthy Volunteers With HIV
This is an open Phase I study of a candidate TB vaccine, MVA85A, in healthy subjects who are infected with HIV. It is designed to study the safety and immunogenicity of the vaccine.
- Trial name
- NCT00731471
- Testing
- MVA85A
- Where
- Senegal
- Volunteers
- 24 people
- Sponsor
- University of Oxford
HIV Infections, TB
A Study of MVA85A, in Asymptomatic Volunteers Infected With TB, HIV or Both
This study is designed to evaluate the safety of MVA85A in asymptomatic volunteers in South Africa who are infected with M.tb, HIV or both.
- Trial name
- NCT00480558
- Testing
- MVA 85A
- Where
- South Africa
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Malaria
Study to Assess Efficacy of New Malaria Vaccine Candidates AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP & MVA ME-TRAP
This study aims to test the safety and efficacy of six new malaria vaccines - AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP \& MVA ME-TRAP.
- Trial name
- NCT01142765
- Testing
- AdCh63 MSP1, MVA MSP1, challenge, AdCh63 AMA1, MVA AMA1, challenge, AdCh63 AMA1, AdCh63 MSP1, MVA AMA1, MVA MSP1, challenge
- Where
- 3 sites in United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pneumococcal Disease
13 Valent Pneumococcal Conjugate Vaccine - Follow-on Study
This is a follow-on, multi-centre, open-label, clinical trial. The purpose of this trial is to investigate the concentrations of serotype-specific antibodies to IgG included in PCV13 in children who have received either the PCV7…
- Trial name
- NCT01095471
- Testing
- PCV13
- Where
- 4 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Kidney Transplantation, Ischemia-Reperfusion Injury
Thymoglobulin Induction in Kidney Transplant Recipients
The purpose of this study is to determine if anti-thymocyte globulin (Thymoglobuline) administration in the kidney transplant recipient is able to reduce the amount of damage that kidneys transplanted from deceased donors…
- Trial name
- TIKT (NCT01239563)
- Testing
- antithymocyte globulin, Basiliximab
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Influenza
Long Term Influenza Prophylaxis With Inhaled Zanamivir or Oral Oseltamivir
This is a multicenter, randomised, four arms placebo controlled study to evaluate the safety and tolerability of 10 mg inhaled zanamivir once a day and 75 mg oseltamivir capsule orally once a day relative to placebo over 16 weeks…
- Trial name
- SEA 004 (NCT00980109)
- Testing
- active oseltamivir, zanamivir for inhalation
- Where
- 2 sites in Thailand
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Routine Mammography
Pilot Study: Age Extension of NHS Breast Screening Programme
The purpose of this pilot study is to assess the feasibility and acceptability of randomising the phasing-in of the age extension of the NHS Breast Screening Programme in six volunteer sites in different areas of England.
- Trial name
- NCT00890864
- Testing
- Invitation for breast screening
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford