Clinical trials: sponsored by University of Oxford
Malaria
Safety and Immunogenicity of Malaria Vaccines AdCh63 AMA1, MVA AMA1 and AMA1-C1/Alhydrogel®+/- CPG 7909
This study aims to compare the safety and immunogenicity of AdCh63 AMA1 and MVA AMA1vaccine candidates administered alone and with adjuvants in various schedules.
- Trial name
- NCT01351948
- Testing
- AdCh63 AMA1 + MVA AMA1 + AMA1-C1/Alhydrogel®+ CPG 7909, AdCh63 AMA1 + AMA1-C1/Alhydrogel®+ CPG 7909, AdCh63 AMA1 + AMA1-C1/Alhydrogel®
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ovarian Cancer
Oxford Ovarian Cancer Predict Chemotherapy Response 01
The purpose of the study is to understand why there are differences between individuals in the way they respond to paclitaxel chemotherapy.
- Trial name
- OXO-PCR-01 (NCT01770535)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Oxford
Influenza
A Study to Determine the Safety and Immunogenicity of Co-administration of the Candidate Influenza Vaccine MVA-NP+M1 and Seasonal Influenza Vaccine
This is a single blinded placebo controlled phase I study, to assess the safety and immunogenicity of co-administration of the candidate influenza vaccine MVA-NP+M1 with seasonal influenza vaccine.
- Trial name
- NCT01465035
- Testing
- TIV and MVA-NP+M1
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
Gefitinib in Treating Patients With Esophageal Cancer That is Progressing After Chemotherapy
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT01243398
- Testing
- quality-of-life assessment
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Oxford
Malaria
A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites
Malaria affects around 515 million people each year, about a million of whom die from the disease. It is a major problem for those who live in affected areas as well as for travellers to affected areas.
- Trial name
- NCT00890760
- Testing
- AdCh63 ME-TRAP, MVA ME-TRAP, Sporozoite challenge
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Safety and Immunogenicity of New Malaria Vaccine Candidate ChAd63 CS Administered Alone and With MVA CS
This is an open label phase I study, to assess the safety of a novel malaria vaccine, AdCh63 CS, simian adenovirus encoding Plasmodium falciparum liver stage antigen, Circumsporozoite protein.
- Trial name
- NCT01450280
- Testing
- ChAd63 CS, ChAd63 CS, MVA CS, ChAd63, MVA CS
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Influenza
A Study to Assess the Safety and Immunogenicity of a New Influenza Vaccine Candidate MVA-NP+M1 in Healthy Adults
This is an open label phase I study, to assess the safety of a novel influenza vaccine, MVA-NP+M1. All volunteers recruited will be healthy.
- Trial name
- NCT00942071
- Testing
- MVA-NP+M1
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Persistent Cough, Whooping Cough
Montelukast for Persistent Cough in Young People and Adults
Persistent cough is a common symptom, accounting for about 20% of referrals to outpatient chest clinics. Most coughs are caused by self-limiting viral infections such as the common cold.
- Trial name
- MAC (NCT01279668)
- Testing
- Montelukast
- Where
- United Kingdom
- Volunteers
- 276 people
- Sponsor
- University of Oxford
Malaria
Safety and Immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP Vaccines in Malaria Endemic Areas
The purpose of this trial is to assess the safety and immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP candidate vaccines in healthy adult volunteers in a malaria endemic region.
- Trial name
- NCT01379430
- Testing
- AdCh63 ME-TRAP followed by MVA ME-TRAP
- Where
- Kenya
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
A BCG Challenge Model Study to Assess Anti-mycobacterial Immunity Induced by BCG and a Candidate TB Vaccine, MVA85A
The purpose of this study is to evaluate the BCG 'challenge' model a four-arm study design has been chosen. Twelve subjects will be recruited into each arm of the study.
- Trial name
- NCT01194180
- Testing
- BCG: 100 microlitres ~ 2-8 x 105 pfu, MVA85A: 1 x 108 pfu BCG: 100 microlitres ~ 2-8 x 105 pfu
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Study of AdCh63 ME-TRAP Alone and With MVA ME-TRAP
This is an open label phase I study, to assess the safety of a novel malaria vaccine, AdCh63 ME-TRAP, simian adenovirus encoding Plasmodium falciparum antigens.
- Trial name
- NCT00890019
- Testing
- AdCh63 ME-TRAP, AdCh63 ME-TRAP; MVA ME-TRAP
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Metastatic Colorectal Cancer, Metastatic Breast Cancer
Dose Adaptation of Capecitabine Using Mobile Phone Toxicity Monitoring
To develop a system to manage side effects and adjust chemotherapy dose such that a patient can receive their personal maximum tolerated dose.
- Trial name
- DATACAP (NCT01053104)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Oxford
Falciparum Malaria
Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria
In Afghanistan, studies over the past 15 years have shown a high degree of Plasmodium falciparum resistance to chloroquine (80%) and more recently an increasing degree of resistance to sulfadoxine-pyrimethamine monotherapy (12%).
- Trial name
- ASPF (NCT01115439)
- Testing
- artesunate plus sulfadoxine-pyrimethamine (AS+SP)
- Where
- 4 sites in Afghanistan
- Volunteers
- 100 people
- Sponsor
- University of Oxford
Metastatic Colorectal Cancer
PERfusion CT in the FOXFIRE Trial to Study Blood Flow to Liver Metastases
The PERFORM study is a pilot study investigating the feasibility and usefulness of performing a novel CT (Computed Tomography)scanning technique called Perfusion CT(CTP) as an addition to normal CT scanning in patients recruited…
- Trial name
- PERFORM (NCT01410760)
- Testing
- Perfusion CT scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Stroke, Cerebral Infarction
Transcranial Stimulation and Motor Training in Stroke Rehabilitation
This study aims to test whether repeated sessions of tDCS result in long-lasting improvements in motor function in patients with chronic stroke.
- Conditions
- Stroke, Cerebral Infarction, Cerebrovascular Disorders, Brain Diseases
- Trial name
- tDCS (NCT01414582)
- Testing
- Anodal tDCS, Motor Training
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Learning
Factors Affecting Medical Student Learning in Simulation Scenarios
Simulation is used to teach undergraduate and postgraduate healthcare professionals, however it is not known how best to use this resource.
- Trial name
- NCT01117467
- Testing
- Simulation scenario
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malignancy
Does Transcranial Magnetic Stimulation of the Cingulate Cortex Modulate the Perception of Dyspnoea?
The treatment we are studying is Transcranial Magnetic Stimulation (TMS). In TMS, an electromagnetic pulse is passed into the brain through a coil placed on the head.
- Trial name
- TMS (NCT00830921)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Knee Osteoarthritis
The Efficacy of Viscosupplementation for Early Knee Osteoarthritis
Treatment for early osteoarthritis (OA) of the knee is an increasing problem yet much of the research into OA, to date, concentrates on predisposition, genetic and cellular aspects and the treatment of late stage disease…
- Trial name
- EVOKE (NCT01210742)
- Testing
- Synvisc One, Routine management
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Vivax Malaria
Pharmacokinetic Study of Primaquine and Chloroquine in Healthy Subjects
This is a standard pharmacokinetic interaction study. Subjects will be randomized to be either group A or B. Group A. Subjects will have 3 hospitalizations to complete.
- Trial name
- PQCQ (NCT01218932)
- Testing
- A, B
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Childhood Pneumonia, Pneumococcal Carriage
The Study of Chest Infections in Infants Living in a Refugee Camp on the Thai-Burmese Border
This study will follow 1000 refugee infants from birth for two years. The aim of the study is to better understand why some children develop infections caused by the bacterium Streptococcus pneumoniae whilst others merely carry…
- Trial name
- ARI (NCT00894764)
- Where
- 2 sites in Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford