Clinical trials: sponsored by University of Oxford
Streptococcus Agalactiae (Streptococcus Group B)
The Clinical and Molecular Epidemiology of Streptococcus Agalactiae Colonisation on the Kenyan Coast
Sub-Saharan Africa (sSA) has the highest regional rates of perinatal mortality worldwide. Group B Streptococcus (GBS) has been identified as a leading cause of early onset neonatal sepsis (EOS, in <7 days of life) in sSA.
- Trial name
- GBS (NCT01757041)
- Where
- 4 sites in Kenya
- Volunteers
- 7,967 people
- Sponsor
- University of Oxford
Tuberculosis (TB)
Phase I Trial Evaluating Safety and Immunogenicity of MVA85A-IMX313 Compared to MVA85A in BCG Vaccinated Adults
This is a Phase I trial to evaluate the safety and immunogenicity of MVA85A-IMX313 vaccination compared to MVA85A vaccination, in BCG vaccinated adults.
- Trial name
- NCT01879163
- Testing
- MVA85A-IMX313, MVA85A
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Meningitis, Septicemia
Understanding the Immune Response to Meningitis Vaccines
The purpose of the study is to evaluate and compare the immune response to two vaccines against 4 related bacteria: meningococcal serogroups A, C, W-135 and Y.
- Trial name
- NCT00901940
- Testing
- Meningococcal (Groups A, C, Y and W-135) Conjugate, Meningococcal polysaccharide A, C, Y and W135 and Menveo
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Influenza
A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Influenza Vaccine ChAdOx1-NP+M1
This is a first in man dose escalation study, to assess the safety and immunogenicity of the candidate influenza vaccine ChAdOx1-NP+M1. All volunteers recruited will be healthy adults aged 18-50.
- Trial name
- NCT01623518
- Testing
- ChAdOx1-NP+M1
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypertension, SMS-text
Effectiveness of SMS-text Message Support for Patients With Hypertension to Improve Blood Pressure
General synopsis for SMS-text Adherence Support (*StAR) Study and associated preparatory and pilot work Background: High blood pressure is an important risk factor for heart disease, stroke and chronic kidney disease.
- Conditions
- Hypertension, SMS-text, mHealth
- Trial name
- *StAR (NCT02019823)
- Testing
- Informational SMS-text, Interactive SMS-text, Enhanced usual care
- Volunteers
- 1,372 people
- Sponsor
- University of Oxford
Plasmodium Falciparum Malaria
A Safety and Efficacy Study of ChAd63/MVA METRAP + RTS,S
This is a clinical trial in which healthy volunteers will be administered experimental malaria vaccines. One group of volunteers will receive vaccination with the leading malaria vaccine candidate, RTS,S/AS01.
- Trial name
- NCT01883609
- Testing
- RTS,S/AS01B, ChAd63 ME-TRAP, MVA ME-TRAP
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Atrial Fibrillation, Myocardium; Injury
Statin Therapy In Cardiac Surgery
The purpose of STICS trial (Statin Therapy In Cardiac Surgery) is to test whether perioperative treatment with Rosuvastatin 20 mg once daily prevents post-operative atrial fibrillation and reduces perioperative irreversible…
- Trial name
- STICS (NCT01573143)
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,922 people
- Sponsor
- University of Oxford
Tuberculosis
Safety Study of Tuberculosis Vaccines AERAS-402 and MVA85A
This trial will investigate the administration of two new tuberculosis vaccines, called AERAS-402 and MVA85A. The purpose of this trial is to assess what happens when both of these vaccines are given one after the other.
- Trial name
- NCT01683773
- Testing
- AERAS-402, MVA85A
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Severe Acute Malnutrition
A Trial of n-3 PUFA-Enriched Ready to Use Therapeutic Food for Childhood Severe Malnutrition
The investigators will perform a randomised controlled trial of the provision of food designed for rehabilitation of malnourished children that is supplemented with n-3 fatty acids compared to usual composition.
- Trial name
- Njugu Plus (NCT01593969)
- Testing
- RUTF/Flax Oil, RUTF/Flax Oil plus additional Fish Oil, Standard RUTF
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Nutrition Disorders, Life-threatening Infection
Cotrimoxazole Prophylaxis in Severely Malnourished Children
This trial aims to test the hypothesis that mortality among Kenyan children with severe malnutrition following initial stabilisation is due to ongoing vulnerability to infectious disease, and that long term daily co-trimoxazole…
- Trial name
- CTX (NCT00934492)
- Testing
- Cotrimoxazole dispersible tablet
- Where
- 4 sites in Kenya
- Volunteers
- 1,781 people
- Sponsor
- University of Oxford
Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Cardiac Insufficiency Following Cardiac Surgery
Statin Therapy In Atrial Refractoriness and Reperfusion Injury
Patients with coronary artery disease are often prescribed drugs called statins because research has shown that, by lowering cholesterol, they reduce the risk of having a heart attack or other complications in the long-term.
- Conditions
- Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Cardiac Insufficiency Following Cardiac Surgery, Atrial Fibrillation, Ischaemia-reperfusion Injury
- Trial name
- STARR (NCT01780740)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
HIV
Targeted Screening of At-Risk Adults for Acute HIV-1 Infection
In this research, the investigators want to see if early detection of HIV infection can be improved by testing young adults who seek urgent health care from pharmacies and healthcare facilities with symptoms similar to those…
- Trial name
- AHI (NCT01876199)
- Testing
- intense follow up
- Where
- Kenya
- Volunteers
- 522 people
- Sponsor
- University of Oxford
Rheumatic Heart Disease, Mitral Stenosis
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
The purpose of this study is to investigate whether there are genetic differences between patients with rheumatic heart disease and members of the general population.
- Trial name
- NCT02188862
- Where
- 3 sites in Fiji, New Caledonia and 1 more
- Volunteers
- 2,372 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hip Osteoarthritis
Wear and Migration in the Corin Mini-Hip/Metafix and ECIMA Polyethylene
The primary objective of this study is to determine whether the Mini Hip (Corin, U.K.) femoral component has a predictable and stable migration pattern (mean migration of the femoral component in three-dimensions,in mm) over a…
- Trial name
- MiniHip (NCT02174965)
- Testing
- MiniHip (Corin U.K.), Metafix (Corin, U.K)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Oxford
Influenza
Safety and Immunogenicity of Co-administration of Candidate Influenza Vaccine MVA-NP+M1 and Viroflu® Seasonal Influenza Vaccine
This is a single blinded placebo controlled phase I study, to assess the safety and immunogenicity of co-administration of the candidate influenza vaccine MVA-NP+M1 with the Viroflu® seasonal influenza vaccine.
- Trial name
- NCT02014168
- Testing
- Viroflu® and MVA-NP+M1
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV-1 Infections
Safety and Immunogenicity Study of Three Candidate HIV-1 Vaccines, Administered in Combination to Healthy HIV-1 Uninfected Adults
This is a randomised, placebo-controlled, single-blind study designed to evaluate the safety and immunogenicity of three novel HIV vaccines.
- Trial name
- HIV-CORE 002 (NCT01151319)
- Testing
- ChAdV63.HIVconsv low dose., ChAdV63.HIVconsv high dose., pSG2.HIVconsv
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Comparison of Two Regimens of Artemether-lumefantrine for the Treatment of Malaria in Pregnancy
Malaria in pregnancy is a major cause of maternal and newborn morbidity and mortality in sub-Saharan Africa]. Effective antimalarial preventive and treatment regimens can significantly reduce malaria-related morbidity and…
- Trial name
- ALN5P (NCT01916954)
- Testing
- 3-day artemether-lumefantrine, 5-day artemether-lumefantrine
- Where
- Republic of the Congo
- Volunteers
- 96 people
- Sponsor
- University of Oxford
Cardiovascular Disease, Peripheral Arterial Disease
Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE
The primary aim is to assess the effects of raising HDL cholesterol (the good type) with extended release niacin/laropiprant 2g (previously known as MK-0524A) versus matching placebo on the risk of heart attack or coronary death…
- Conditions
- Cardiovascular Disease, Peripheral Arterial Disease, Diabetes Mellitus, Coronary Heart Disease
- Trial name
- HPS2-THRIVE (NCT00461630)
- Testing
- ER niacin/laropiprant, simvastatin, ezetimibe/simvastatin
- Where
- United Kingdom
- Volunteers
- 25,673 people
- Sponsor
- University of Oxford
Depression
OxIGen: Oxford Imagery Generation: Investigating the Effects of an Internet Based Computer Program in Depression
This research study is designed to investigate the effects of an online computer program, called OxIGen (Oxford Imagery Generation), on thinking style and mood in depression.
- Trial name
- OxIGen (NCT01443234)
- Testing
- OxIGen, OxIGen: control version
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Child Behavior Disorders, Parenting
RCT of Brief Universal Parenting Program to Prevent Child Behavioural and Emotional Difficulties in Greece
This study investigates the impact of a Triple P Seminar Series on positive parenting for universal prevention of behavioural and emotional difficulties in a general Greek sample of parents with children aged 2 to 12.
- Trial name
- NCT02030730
- Testing
- Triple P Seminar Series
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Oxford