Clinical trials: sponsored by University of Oxford
Major Depressive Disorder (MDD)
Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
Previous work demonstrated that individuals are able to self-regulate their ventral tegmental area (VTA) activity using real-time biofeedback.
- Trial name
- NCT07694076
- Testing
- Active Biofeedback
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Plasmodium Vivax Infection
Vivax Malaria Human Infection Studies in Thailand
This study is a human challenge study to assess the feasibility and safety of controlled human malaria infection (via P. vivax sporozites) in healthy volunteers, and to develop a bank of P.
- Trial name
- MIST1 (NCT04083508)
- Testing
- Mosquito bites
- Where
- Thailand
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV
Combination Vaccination and Broadly Neutralising Antibody Therapy in HIV
There is no cure for HIV infection. Antiretroviral therapy (ART) is widely available but requires daily, life-long intake. This can cause issues around side-effects, resistance, adherence and stigma.
- Trial name
- AbVax (NCT07054931)
- Testing
- ChAdOx1.tHIVconsv1, ChAdOx1.HIVconsv62, MVA.tHIVconsv4
- Where
- 3 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Diabetes Mellitus, Type 2
A Study of Cardiovascular Events iN Diabetes Plus
ASCEND PLUS is testing whether, for people with type 2 diabetes who have not previously had a heart attack or stroke, regularly taking a tablet called semaglutide can safely help to reduce heart attacks, strokes, mini-strokes…
- Trial name
- ASCEND PLUS (NCT05441267)
- Testing
- Semaglutide Oral Tablet
- Where
- United Kingdom
- Volunteers
- 21,296 people
- Sponsor
- University of Oxford
Psoriatic Arthritis
Multicentre ObservatioNal Initiative in Treat to Target Outcomes in Psoriatic Arthritis
MONITOR is a cohort study recruiting patients with a new diagnosis of psoriatic arthritis (PsA) which will establish outcomes using a pragmatic feasible 'treat to target' approach in a real-life clinic population.
- Trial name
- MONITOR (NCT03531073)
- Testing
- Methotrexate
- Where
- United Kingdom
- Volunteers
- 446 people
- Sponsor
- University of Oxford
Mental Health, Violence Against Children
Hope Groups: Parenting and Mental Health Among Refugees in the Middle East
This research is testing if 'Hope Groups' -- a psychosocial, mental health, parenting strengthening, and violence prevention support group program -- work to help Palestinian caregivers displaced by war.
- Trial name
- NCT07506421
- Testing
- Hope Groups
- Where
- Jordan
- Volunteers
- 490 people
- Sponsor
- University of Oxford
Carpal Tunnel Syndrome, Neurodynamic Treatment
Mechanisms of Neurodynamic Treatments
INTRODUCTION: Carpal tunnel syndrome (CTS) is a relatively common condition caused by compression of one of the main nerves at the wrist, the median nerve.
- Conditions
- Carpal Tunnel Syndrome, Neurodynamic Treatment, Nerve Mobilisation, Diffusion MRI
- Trial name
- MONET (NCT05859412)
- Testing
- Neurodynamic exercises, Steroid injection (Depomedrone 40mg), Advice
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Duchenne Muscular Dystrophy (DMD)
A Remote Study Using Technology to Assess Outcomes in DMD
Every year, 100 boys are born in the UK with a rare muscle disease called Duchenne muscular dystrophy. These boys cannot make an important muscle protein called dystrophin.
- Trial name
- TODDLER (NCT07423026)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Positive Parenting, Child Maltreatment
Parenting in the Preschool System in Malaysia
This study aims to evaluate the effectiveness of a hybrid human-digital playful parenting programme, "Naungan Kasih-Hybrid (NK-Hybrid)", in Malaysia.
- Conditions
- Positive Parenting, Child Maltreatment, Child Development, Child Behavior
- Trial name
- NCT07599566
- Testing
- Naungan Kasih Positive Parenting Programme
- Where
- Malaysia
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Lung Cancer
SCOOT: Sample Collection for DART
The study will use a blood sample collected from participants to: Develop new ways of finding and diagnosing lung health problems, such as lung cancer.
- Trial name
- SCOOT (NCT05368298)
- Where
- 11 sites in United Kingdom
- Volunteers
- 872 people
- Sponsor
- University of Oxford
Psoriatic Arthritis, Psoriasis (PsO)
Inflammation Digital Biomarkers Validation Study
HIPPOCRATES is an Innovative Medicines Initiative (IMI) funded EU Consortium established to address key unmet clinical needs in psoriatic disease.
- Trial name
- IDBV (NCT07594054)
- Volunteers
- 3,458 people
- Sponsor
- University of Oxford
Atrial Fibrillation New Onset, New Onset Atrial Fibrillation
Tracking Atrial Fibrillation After Intensive Care Admission
Atrial fibrillation (AF) is a heart problem that causes an irregular heartbeat. It can cause the heart to beat more rapidly and reduce the heart's ability to pump blood around the body efficiently, causing heart failure.
- Conditions
- Atrial Fibrillation New Onset, New Onset Atrial Fibrillation, Atrial Fibrillation
- Trial name
- TrAFFIC (NCT05229211)
- Testing
- Cardiac monitoring
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Oxford
Diabetes, Atrial Fibrillation (AF)
Unrecognised Comorbidity Detection in Hospitalised Patients
Over two million people in the UK are unaware that they're living with a long-term (chronic) health condition, such as diabetes or a heart problem.
- Conditions
- Diabetes, Atrial Fibrillation (AF), Cardiac Disease
- Trial name
- CODETECT (NCT06881797)
- Where
- United Kingdom
- Volunteers
- 4,500,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
ParentText + 1 In-person Session, ParentText + 1 In-person Session + WhatsApp Support
Pilot Factorial Trial in Malaysia
This pilot study aims to determine the feasibility, acceptability, and engagement for different combinations of three components of a human-digital hybrid playful parenting programme, "Naungan Kasih (NK) Parenting Programme", in…
- Conditions
- ParentText + 1 In-person Session, ParentText + 1 In-person Session + WhatsApp Support, ParentText + 2 In-person Sessions, ParentText + 2 In-person Sessions + WhatsApp Support
- Trial name
- NCT07592351
- Testing
- Naungan Kasih Text (NKText) + onboarding session, WhatsApp support groups, Closing session
- Where
- Malaysia
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause
Probiotic Intake and Perimenopausal Psychological Assessments
Recent evidence suggests multi-strain probiotics containing Lactobacillus rhamnosus and Bifidobacterium longum have been found to enhance emotional processing and reduce salience to negative cues in studies involving people with…
- Conditions
- Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause, Perimenopause-Related Depression, Perimenopausal Women
- Trial name
- PIPPA (NCT07590999)
- Testing
- Multi-strain probiotic
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Oxford
Malaria, Plasmodium Falciparum
A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21
This is a Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-MTM and the pre-erythrocytic stage…
- Trial name
- NCT05357560
- Testing
- Matrix-M with RH5.2 VLP and/or R21
- Where
- The Gambia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Fibromyalgia
A Study of Digital Cognitive Behavioural Therapy for Insomnia in Fibromyalgia
The goal of this clinical trial is to investigate the potential benefits of a digital Cognitive Behavioural Therapy for Insomnia (dCBT-I) platform, Sleepio, in individuals suffering from fibromyalgia, a condition commonly…
- Trial name
- Pain-LESS (NCT05962138)
- Testing
- Digital Cognitive Behavioural Therapy for Insomnia
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Iron-deficiency
Imaging Intravenous Iron
The aim of this study is to track where the iron goes in different tissues in the hours, days and weeks after an intravenous iron infusion.
- Trial name
- NCT05609318
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Nutritional and Metabolic Diseases
Blood Lipid Responses to Diet Macronutrients
The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of…
- Trial name
- BoLD (NCT05973539)
- Testing
- Diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ketosis, Exogenous Ketosis
Exogenous Ketosis in a Fed and a Fasted State
The kinetics of circulating βHB following ingestion of the ketone monoester are dependent on several variables that determine the balance between appearance into, and disappearance from, the bloodstream.
- Trial name
- NCT06320522
- Testing
- Ketone Monoester
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oxford