Clinical trials: completed, sponsored by University of Chicago
Sleep Apnea, Pre-diabetes
Mechanisms of Prediabetic States in Sleep Apnea
The purpose of this study is to better understand how sleep apnea contributes to the development of diabetes.
- Trial name
- NCT04234217
- Testing
- Continuous positive airway pressure, Niacin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Borderline Personality Disorder, Major Depressive Disorder
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder
The primary objective of the study is to evaluate the safety and efficacy of psilocybin in adults with major depressive disorder (MDD) and borderline personality disorder (BPD).
- Trial name
- NCT05399498
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Kidney Cancer
Randomized Evaluation of Patients Who Have Had Laparoscopic Partial Nephrectomy
The purpose of this study is to evaluate the necessity of using hemostatic agents as a tool when performing robotic partial nephrectomy in the treatment of kidney cancer.
- Trial name
- NCT04120805
- Testing
- Hemostatic Agent, No Hemostatic Agent
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Chicago
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder, OCD
A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD.
- Trial name
- NCT05624528
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Chicago
Frailty
Voice-Activated Technology to Improve Mobility in Multimorbid, Frail, Homebound Older Adults (EngAGE)
The purpose of this study is to test the efficacy of EngAGE (an interactive, voice-activated app) vs usual care on improving older adult physical and social function.
- Trial name
- EngAGE (NCT05337514)
- Testing
- Enhanced Engagement, Standard Engagement
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Chicago
Cancer
Engaging and Activating Cancer Survivors in Genetic Services Study
To address the gap in access to genetic services, this study will evaluate the effectiveness of an adapted model of remote delivery of genetic services to increase the uptake of recommended genetic assessment and testing in…
- Trial name
- ENGAGE (NCT04455698)
- Testing
- Remote Telegenetic Counseling by Phone, Remote Telegenetic Counseling by Videoconferencing, Usual Care Arm
- Where
- 3 sites in United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Surgery
Brain Function Monitoring During Surgery
The purpose of this research is to gather information on the effectiveness of the Sedline Brain Function Monitor, and its use in this study to determine whether monitoring the brain activity during anesthesia will improve…
- Trial name
- NCT06619730
- Testing
- Sedline Brain Function Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Health Related Social Needs (HRSN)
CommunityRx-Dementia
Caregivers of home-dwelling people with Alzheimer's Disease and related dementias (ADRD) are one of the most rapidly growing populations in the United States.
- Trial name
- CRx-D (NCT04146545)
- Testing
- Community Rx-Dementia "CRxD" Caregiver Resources
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Chicago
COVID-19
Can Vitamin D Reduce the Burden of COVID-19?
The purpose of this study is to compare the risks of COVID-19 in individuals from the Chicagoland area and other communities in the United States randomized to low (400 IU/day) versus moderate (4,000 IU/day) dose vitamin D.
- Trial name
- NCT07128069
- Testing
- Vitamin D 400IU, Vitamin D 4000IU
- Where
- United States
- Volunteers
- 2,093 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Borderline Personality Disorder
Caplyta in Borderline Personality Disorder
The primary objective of the proposed study is to evaluate the safety and efficacy of Caplyta (lumateperone) in adults with borderline personality disorder (BPD).
- Trial name
- NCT05356013
- Testing
- Caplyta
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Food Insecurity
CommunityRx-Hunger
CommunityRx-Hunger (CRx-H) is a hospital-based intervention that addresses food insecurity and other health-related social needs such as transportation, housing, utilities, and safety.
- Trial name
- CRx-H (NCT04171999)
- Testing
- Community Rx-Hunger (CRx-H)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dementia, Hip Pain
Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments
The purpose of this study is to learn if the Pain in Advanced Dementia (PAINAD) scale can improve emergency pain care in persons living with dementia (PLWD).
- Conditions
- Dementia, Hip Pain, Emergency Department Patient, Pain in Advanced Dementia Scale
- Trial name
- NCT06370572
- Testing
- PAINAD EHR Prompt
- Where
- 2 sites in United States
- Volunteers
- 2,421 people
- Sponsor
- University of Chicago
SARS-CoV-2 Infection
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19
The purpose of this study is to compare the risks of COVID-19 in individuals from Chicagoland communities randomized to low (400 IU/day) vs. moderate (4,000 IU/day) or high (10,000 IU/day) dose vitamin D.
- Trial name
- NCT04868903
- Testing
- Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 1,475 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Invasive Mechanical Ventilation, Children With Medical Complexity
Parent-to-parent Coaching While Awaiting Hospital Discharge With a Child With a Ventilator
The objective of the study is to pilot a parent-to-parent coaching model with experienced family members of children with Invasive Mechanical Ventilation (IMV) as parent coaches.
- Conditions
- Invasive Mechanical Ventilation, Children With Medical Complexity, Home Nursing, Empowerment
- Trial name
- NCT05880953
- Testing
- Parent-to-parent coaching
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
LSD, Major Depressive Disorder
Mood Effects of Serotonin Agonists: Depression
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression.
- Conditions
- LSD, Major Depressive Disorder, Depression
- Trial name
- MESA-D (NCT07017478)
- Testing
- LSD
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Delta-9-tetrahydrocannabinol (THC), Stress
Effects of Drugs on Stress Memories
There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences.
- Trial name
- ETS (NCT06471647)
- Testing
- delta-9-tetrahydrocannabinol (THC) (5), delta-9-tetrahydrocannabinol (THC) (10)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Chicago
LSD
Drug Effects on Mood and Behavior - Expectancy
This study will examine the effects of a single low dose of the 5HT2A agonist LSD (Lysergic Acid Diethylamide) (13 µg) or placebo in individuals who are or are not explicitly told what drug they will receive.
- Trial name
- MESA-X (NCT07061886)
- Testing
- LSD
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Chicago
COPD, COPD Exacerbation Acute
The Reducing REVISITS Study: A Cluster RCT
This type II hybrid effectiveness-implementation trial will concurrently study the comparative effectiveness of virtual vs. in-person COPD care transition programs implemented via virtual mentored implementation approaches with…
- Trial name
- REVISITS (NCT05568043)
- Testing
- COPD Transitions of Care Intervention Bundle: Virtual Interventions, COPD Transitions of Care Intervention Bundle: In-Person Interventions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of Chicago