Clinical trials: open to volunteers, sponsored by University of Alabama at Birmingham
Language Disorders
Neurophysiological Mechanisms of Language Comprehension
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators…
- Trial name
- NCT05283265
- Testing
- Sentence Type, Direct brain stimulation
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes
Remotely Delivered Mindfulness-Based Diabetes Education
Diabetes distress is common affecting over one-third of people with type 2 diabetes, negatively impacting self-management and outcomes, and disproportionately affecting low-income individuals.
- Trial name
- NCT06312553
- Testing
- Remotely delivered Mindfulness-Based Diabetes Education, Standard Diabetes Self Management Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Prematurity
Milk And Growth In Children (MAGIC) Born Very Preterm: A Randomized Trial
The goal of this multi-center randomized, parallel group trial is to determine the effect of human milk diets ranging between 180 and 200 mL/kg/day on the body composition outcomes of moderately preterm infants born between 27…
- Trial name
- MAGIC (NCT06420531)
- Testing
- Human milk
- Where
- 4 sites in United States
- Volunteers
- 486 people
- Sponsor
- University of Alabama at Birmingham
Acellular Dermal Matrix, Bone Grafting
Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix
This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.
- Conditions
- Acellular Dermal Matrix, Bone Grafting, Soft Tissue Grafting
- Trial name
- NCT07613047
- Testing
- Guided Bone Regeneration with ADM (AlloDerm) as a barrier, Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer
A Motion Exergaming Approach for Symptom Management: HNC
This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment.
- Trial name
- NCT04632654
- Testing
- A personalized Physical Activity intervention with fitness graded Motion Exergames (PAfitME)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Rheumatologic Disease, Autoimmune Diseases
Testimonials and Navigation in Rheumatology
The overall goal of this study is to determine whether a novel, multi-modal, patient-directed behavioral intervention initiated in rheumatology clinics is an effective approach to improve uptake of updated COVID-19 vaccine.
- Trial name
- TANGO (NCT06469788)
- Testing
- Video comprised of AIRD patient narratives on COVID-19 vaccination thoughts and experiences, Video on the importance of good oral health for patients with AIRD, Brochure on COVID-19 vaccination in AIRD patients
- Where
- 4 sites in United States
- Volunteers
- 1,170 people
- Sponsor
- University of Alabama at Birmingham
Subarachnoid Hemorrhage, Aneurysmal
Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx).
- Trial name
- NCT06932640
- Testing
- - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Median Arcuate Ligament
Novel Feasibility Study Demonstrating the Utility of the Intuitive Da Vinci Single Port Robotic System for Treatment of Median Arcuate Ligament Release
This is a prospective, non-randomized, single arm, single center feasibility study to investigate surgical feasibility and technical success of robotic treatment for Median Arcuate Ligament Syndrome using the Intuitive Da Vinci…
- Trial name
- NCT07888764
- Testing
- Single Port Robotic Median Arcuate Ligament Release
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
Our goal is to better understand how DBS modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy.
- Trial name
- NCT06169852
- Testing
- Unilateral dual-target (STN/GPi) DBS
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Idiopathic Pulmonary Fibrosis
Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary Fibrosis
This Phase IIb trial will compare effectiveness and safety of a multi-component autoantibody reduction therapy (AART), consisting of therapeutic plasma exchange (TPE), rituximab, and intravenous immunoglobulin (IVIg) for…
- Trial name
- STRIVE II (NCT07674745)
- Testing
- Therapeutic Plasma Exchange, Rituximab, Intravenous immunoglobulin
- Where
- 9 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Alabama at Birmingham
Suicide
THRIVE: A Recovery-Focused Suicide Prevention Intervention in Crisis Stabilization Centers
Suicide is a major public health concern in the United States, with more than 1.4 million adults attempting suicide and nearly 50,000 adults dying by suicide each year.
- Trial name
- THRIVE (NCT07784634)
- Testing
- Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE), Center Care as Usual
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- University of Alabama at Birmingham
Cancer, Pain
Cancer Pain 101: A Digital, Asynchronous Intervention of Pain Management in Advanced Cancer
This is a Stage 1 study of a behavioral intervention, which means that a new intervention is being pilot tested to understand whether it is acceptable and feasible for people with advanced cancer to use.
- Conditions
- Cancer, Pain, Advanced Cancer
- Trial name
- COPES Aim 3 (NCT07852468)
- Testing
- Cancer Pain 101
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Myopia
Wavelength Intervention for Nearsighted Kids
The goal of this clinical trial is to learn if daily brief periods of specialized soft contact lens wear work to slow the progression of nearsightedness in children.
- Trial name
- WINK (NCT06598423)
- Testing
- Specialized soft contact lens 1, Specialized soft contact lens 2
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Accidental Overdose of Opiate
Remote Intervention to Prevent Overdose
This Type 1 hybrid effectiveness-implementation randomized controlled trial, A Remote Intervention to Prevent Overdose among People who Use Stimulants and/or Opioids, aims to address the United States opioid crisis driven by…
- Trial name
- NCT07128485
- Testing
- Overdose prevention resources, Overdose prevention education
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors
This is a two-arm randomized controlled trial (RCT) to determine the feasibility of a larger, fully powered trial in younger ER+ BCS undergoing endocrine therapy in the Deep South and to evaluate preliminary effectiveness of a…
- Trial name
- NCT07501637
- Testing
- Breath-Body-Mind (BBM), Survivorship education program (SEP)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Malocclusion
Comparison of Orthodontic Molar Protraction With and Without Adjunctive Surgery
This study will compare orthodontic molar protraction with and without adjunctive periodontally accelerated osteogenic orthodontic (PAOO) surgery prior to orthodontic tooth movement.
- Trial name
- PAOO (NCT03794726)
- Testing
- Orthodontic Molar Protraction and PAOO, Orthodontic Molar Protraction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pneumonia
Ketogenic Approach to Restore Muscle in Older Patients With Community-Acquired Pneumonia - KARMA-P Trial
The purpose of the study is to see if a ketogenic diet compared to a standard diet is better to maintain muscle function and health in hospital admitted pneumonia patients.
- Trial name
- NCT07308483
- Testing
- Ketogenic feeding, Standard feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Knee, ACL
Restoration of Knee Extension After ACL Reconstruction
The purpose of this study is to determine whether the addition of a home-based high-intensity knee extension stretching device (Ermi Knee Extensionater) to standard postoperative physical therapy improves recovery of full knee…
- Trial name
- NCT07685561
- Testing
- Standard Physical Therapy, Ermi Knee Extensionater
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Alabama at Birmingham
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
HIV Infections, Contraception
Pharmacokinetic Study of Long-acting Antiretrovirals and Contraceptives in HIV
This study is being done to understand how long-acting injectable cabotegravir (CAB-LA) used for HIV pre-exposure prophylaxis (PrEP) and hormonal contraceptive methods affect each other when used at the same time.
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction, PrEP
- Trial name
- PHARAOH (NCT07516548)
- Testing
- Long-acting injectable cabotegravir (CAB-LA), No PrEP
- Where
- Botswana
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham