Clinical trials: open to volunteers, sponsored by University of Alabama at Birmingham
Head and Neck Cancer (H&N)
Evaluating Avive+ Soft Tissue Matrix for Prevention of Superficial Radial Nerve Morbidity Following Radial Forearm Free Flap Harvest
Radial forearm free flap (RFFF) reconstruction is commonly used for head and neck defects but is associated with donor-site morbidity, including neuropathic pain and sensory disturbance.
- Trial name
- NCT07558096
- Testing
- Standard Closure (Control), Avive+ Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Dental Implant
To Compare the Two Implant Placement Protocols to Evaluate Placement Accuracy and Post-operative Healing of the Implant
The goal of this study is to evaluate two commonly utilized surgical guide protocols to determine dental implant placement accuracy compared to pre-operative computerized planning, post-operative healing and bone levels to…
- Trial name
- NCT07512258
- Testing
- Pilot Drill Guide (PDG), Fully Guided (FG)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acellular Dermal Matrix, Alveolar Mucosa
Assessment of Two Soft Tissue Augmentation Using Acellular Dermis Around Dental Implants
This study aims to compare soft tissue grafting with acellular dermis at Phase I or Phase II dental implant surgery.
- Trial name
- NCT07512245
- Testing
- Phase I dental implant placement with acellular dermis, Phase II dental implant uncovery with acellular dermis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Rheumatoid Arthritis
RA-PRO PRAGMATIC TRIAL
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab…
- Trial name
- RA-PROPR (NCT04692493)
- Testing
- targeted synthetic DMARD class, non-TNFi-biologic class
- Where
- 49 sites in United States, Canada
- Volunteers
- 924 people
- Sponsor
- University of Alabama at Birmingham
Extreme Prematurity, Enteral Nutrition
High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants
This Phase II, parallel-group, masked, randomized clinical trial aims to evaluate whether a DHA/ARA-enriched, fortified human milk diet administered during the first 14 days of life reduces respiratory morbidity and improves lung…
- Conditions
- Extreme Prematurity, Enteral Nutrition, Bronchopulmonary Dysplasia
- Trial name
- MEND-BPD (NCT07307612)
- Testing
- High-energy group, Standard-energy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Hidradenitis Suppurativa
Regulation of Inflammatory Genes in Hidradenitis Suppurativa
The purpose of this protocol is to examine the cytokine profi le of pati ents with hidradeniti s suppurati va (HS) and idemechanisms responsible for post-transcripti onal regulati on of these genes.
- Trial name
- NCT05507125
- Testing
- Mental health
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Syndrome
Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness
The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage.
- Trial name
- NCT07266571
- Testing
- Pycnogenol, 100mg, Pycnogenol, 200mg, Pycnogenol, 400mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Traumatic Injury
Ketogenic Feeding for Muscle Preservation After Trauma
The purpose of this study is to determine whether a ketogenic diet, provided as tube feeding, compared with a standard hospital tube feeding, is safe and feasible and helps preserve muscle mass and improve metabolic health in…
- Trial name
- KETO TRAUMA (NCT07827820)
- Testing
- Ketogenic feeding, Standard feeding
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Low Birth Weight, Kangaroo Mother Care
Admission to Kangaroo Mother Care (KMC) Ward and Maternal Postpartum Depression
The goal of this clinical trial is to learn if extended admission to the Kangaroo Mother Care (KMC) ward helps to prevent postpartum depression in mothers of low birthweight infants in a low-resource setting whose newborns were…
- Conditions
- Low Birth Weight, Kangaroo Mother Care, Postpartum Depression, Neurodevelopmental Outcome
- Trial name
- KMC PPD (NCT06545760)
- Testing
- Kangaroo mother care (KMC) support for > 2 days, Kangaroo mother care (KMC) support for < 2 days
- Where
- Zambia
- Volunteers
- 1,908 people
- Sponsor
- University of Alabama at Birmingham
Osteopenia
Time-Restricted Eating and Exercise for Bone Health
The purpose of this study is to learn whether combining time-restricted eating with supervised resistance exercise can improve bone health in adults with osteopenia.
- Trial name
- OSTEO-FIT (NCT07824375)
- Testing
- Time-restricted eating combined with resistance exercise (TRE+Ex), Habitual eating pattern combined with resistance exercise (HE+Ex)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Obesity & Overweight, Healthy Adult
Vitis Intervention Trial in Substrate Metabolism
Obesity is associated with reduced metabolic flexibility (MetFlex), the capacity to shift between carbohydrate and lipid oxidation in response to nutrient availability.
- Trial name
- VITIS (NCT07800988)
- Testing
- Freeze-Dried Whole Grape Powder
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Syphilis, Congenital
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates
The Investigator hypothesize that the treatment efficacy will be similar in both study arms. Secondary outcomes and endpoints will characterize safety by comparing adverse events (AEs), tolerability, and adherence to therapy in…
- Trial name
- NCT07457385
- Testing
- Benzathine Penicillin, Amoxicillin
- Where
- 11 sites in United States
- Volunteers
- 374 people
- Sponsor
- University of Alabama at Birmingham
Hidradenitis Suppurativa
Evaluate the Safety and Efficacy of Subcutaneous Siplizumab in the Treatment of Hidradenitis Suppurativa.
This study is to investigate the efficacy of siplizumab in the treatment of Hidradenitis Suppurativa.
- Trial name
- NCT06326476
- Testing
- Siplizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Hepatocellular Carcinoma
A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC
This is a phase Ib/II, dose escalation and dose expansion study of valemetostat (DS-3201) with atezolizumab and bevacizumab in patients advanced Hepatocellular carcinoma (HCC) who did not receive prior systemic therapy for…
- Trial name
- NCT06294548
- Testing
- Valemetostat, Atezolizumab, Bevacizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stone, Urolithiasis, Calcium Oxalate
Heterozygous Individuals for AGXT and Kidney Stones
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production.
- Trial name
- NCT04430426
- Testing
- Controlled Diet
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Schizophrenia Disorders
Activities to Change Your Mood: A Test of the Acceptability and Initial Efficacy in Clinical Samples and Healthy Controls
This is a study investigating how brief online activities can influence mood and attitudes.
- Trial name
- NCT06911723
- Testing
- Brief Activities
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Minority Stress
Minority Stress Counseling for LGBTQ+ Individuals
Lesbian, gay, bisexual, transgender, and queer+ (LGBTQ+) individuals experience a breadth of mental health disparities. Reducing these disparities is an area of key psychological research.
- Trial name
- MST (NCT06614868)
- Testing
- Acceptance and Commitment Therapy, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Distress Syndrome
The ARISE Study - Use of Vertical Positioning
The pilot study will randomize 40 ARDS patients who if proning were required would be randomized to upright bed positioning or to stand of care with bed in the head of bed elevation position
- Trial name
- ARISE (NCT07025421)
- Testing
- Intervention Upright Bed positioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stones, Kidney Calculi
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06989320
- Testing
- Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- NCT05096273
- Testing
- ReACT
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham