Clinical trials: open to volunteers, sponsored by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Lead sponsor (exact) Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Status Open to volunteers
Stomach Neoplasms
Candonilimab Combined With Fruquintinib and Paclitaxel Albumin-Bound as Second-Line Treatment for Advanced Gastric or Gastro-esophageal Junction Adenocarcinoma
This is a Phase II Study of Candonilimab Combined with Fruquintinib and Paclitaxel Albumin-Bound as Second-Line Treatment for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT07920224
- Testing
- candonilimab combined with fruquintinib and paclitaxel albumin-bound
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDS
Monitoring pulmonary perfusion is crucial in critical care, especially for conditions like ARDS. Electrical Impedance Tomography (EIT) is a valuable, non-invasive tool for real-time bedside monitoring.While well-established for…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Mechanical Ventilation
- Trial name
- NCT07908368
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis)
Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance
Lung cancer is the malignant tumor with the highest incidence and mortality rates in China. Malignant pleural effusion (MPE) is one of its most common complications, affecting approximately 15%-50% of patients with non-small cell…
- Trial name
- NCT07882758
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Cancer, HER2-negative Breast Cancer
Albumin-Bound Paclitaxel (Ⅱ) in Patients With Advanced Breast Cancer
This is a multicenter, prospective, observational real-world study. The study aims to evaluate the efficacy, safety and economic benefits of albumin-bound paclitaxel (Ⅱ) compared with conventional albumin-bound paclitaxel, in…
- Conditions
- Breast Cancer, HER2-negative Breast Cancer, Advanced Breast Cancer
- Trial name
- NCT07899047
- Testing
- Experimental Group, control group
- Where
- China
- Volunteers
- 1,372 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pulmonary Nodules, Lung Neoplasms
Longitudinal AI-Assisted Management of Indeterminate Pulmonary Nodules
Patients with indeterminate lung nodules often face a choice between continued CT surveillance and invasive investigation. This trial compares management with or without access to an AI report that matches nodules across real…
- Trial name
- NCT07895277
- Testing
- AI-Assisted Longitudinal CT Assessment and Pulmonary Nodule Management
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pneumonia; Pulmonary Infection
A Multicenter Randomized Trial of CT-Based AI Decision Support for Early Pneumonia Care
Adults hospitalized with pneumonia who need new or increased oxygen support or have defined immunocompromise will be assigned to usual care with or without access to a CT-based AI report.
- Trial name
- NCT07895290
- Testing
- CT-Based AI Decision Support for Pneumonia
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Gastric Neoplasms
Exploring the Efficacy of Ferrous Sulfate/Ferrous Succinate Combined With Serplulimab and SOX Regimen in Neoadjuvant Therapy for Gastric Cancer: A Prospective Cohort Study
Patients with locally advanced gastric cancer have a high risk of postoperative recurrence. Neoadjuvant chemotherapy can improve the R0 resection rate, but some patients gain limited benefit from conventional chemotherapy.
- Trial name
- NCT07872696
- Testing
- Ferrous succinate, Ferrous Sulfate, Serplulimab
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Inflammatory Response
Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Severe sepsis is the most common cause of death among critically ill patients in non-coronary intensive care…
- Trial name
- NCT05875740
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Septic Shock
Sepsis ICU Gut Microbiome Analysis
Sepsis is a life-threatening condition in which the body's response to an infection damages its own organs. This study aims to understand how the bacteria living in the gut change during sepsis and whether patterns of gut…
- Trial name
- SIGMA (NCT07864818)
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Refractory Enteral Feeding Intolerance, Gut Microbiota
Gut Microbiota Structure, Functional and Metabolic Profiles, and Composite Biomarkers in ICU Adults With Refractory Enteral Feeding Intolerance
Some adults in the intensive care unit (ICU) cannot receive enough nutrition through a feeding tube because of persistent digestive problems, even after standard measures to improve feeding.
- Conditions
- Refractory Enteral Feeding Intolerance, Gut Microbiota, Metabolic Profiles
- Trial name
- NCT07864844
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Enteral Feeding Intolerance, ICU
Transcutaneous Auricular Stimulation Targeting Enteral Feeding Intolerance
This study will test whether electrical stimulation applied to the outer ear can improve tolerance of tube feeding in critically ill adults in the intensive care unit (ICU).
- Trial name
- TASTE-FI (NCT07854236)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Non-Small Cell Lung Cancer
Quad Shot Radiotherapy Combined With Tislelizumab and Platinum-Based Chemotherapy Before Surgery for Stage II-III Non-Small Cell Lung Cancer
This study aims to evaluate a new pre-surgery (neoadjuvant) treatment for patients with stage II-III non-small cell lung cancer (NSCLC). Currently, standard pre-surgery treatment involves immunotherapy combined with chemotherapy.
- Trial name
- QS-NSCLC (NCT07845916)
- Testing
- Quad Shot Radiotherapy, Tislelizumab, Carboplatin or cisplatin
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit
Propofol or Esketamine: Tracheal Intubation Comparison
The goal of this clinical trial is to compare how esketamine and propofol affect blood pressure in critically ill adults who need a breathing tube in an intensive care unit (ICU).
- Trial name
- POETIC (NCT07847255)
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cerebrovascular Diseases, Lung
Clinical Application of a Low-Dose CBCT AI Model
Cone Beam CT (CBCT) is an imaging modality used in interventional digital subtraction angiography (DSA). It produces three-dimensional images via cone-beam X-ray scanning and computer reconstruction.
- Conditions
- Cerebrovascular Diseases, Lung, Liver
- Trial name
- NCT07845929
- Testing
- DeepPriorCBCT-V2, Clinical standard protocol (Full-radiation-dose CBCT)
- Where
- 5 sites in China
- Volunteers
- 1,380 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Septic Shock
Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study
Sepsis remains a leading cause of critical illness worldwide, yet the underlying mechanisms driving its profound and persistent immune dysfunction are incompletely understood.
- Trial name
- NCT07667153
- Testing
- Bone marrow aspirate collection
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Critical Illness
FMT for 90-Day Outcome of Clinical Use in ICU Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, representing one of the leading causes of death in intensive care units (ICUs) worldwide.
- Conditions
- Sepsis, Critical Illness, Gastrointestinal Dysfunction, Dysbiosis
- Trial name
- FOCUS (NCT07670299)
- Testing
- Gut microbiota suspension
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
CRC (Colorectal Cancer)
Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM
Efficacy and safety of retlirafusp alfa combined with bevacizumab and chemotherapy with or without short-course radiotherapy in conversion therapy for advanced colorectal cancer liver metastases: an exploratory study.
- Trial name
- NCT07728019
- Testing
- SCRT, Retlirafusp alfa Injection, Bevacizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Cancer
AI-Assisted Chest CT Interpretation Across the Lung Cancer Care Continuum
This investigator-initiated, single-center study consists of a retrospective artificial intelligence model-development stage and a prospective physician reader-study stage.
- Trial name
- NCT07829640
- Testing
- Chest CT Artificial Intelligence Decision-Support System
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology