Clinical trials: open to volunteers, sponsored by The University of Texas Health Science Center, Houston
- Lead sponsor (exact) The University of Texas Health Science Center, Houston
- Status Open to volunteers
Epilepsy, Brain Tumor
Mapping of Human Cognition
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe…
- Trial name
- NCT05989893
- Testing
- Language-based tasks
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia Spectrum Disorders (SSD)
Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention
The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults…
- Trial name
- NCT07743645
- Testing
- Psychosocial intervention group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or…
- Trial name
- NCT05213676
- Testing
- Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hernia
Patient Priorities Aligned Discrete Decision Making for Older Adults With Multiple Chronic Conditions.
The purpose of the study is to to evaluate an artificial intelligence (AI) powered large language model (LLM) chatbot -PrioritiesAI -that assists patients in understanding, clarifying, and communicating their health priorities…
- Trial name
- NCT07848386
- Testing
- AI Chatbot
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Multiple Sclerosis
Efficacy of Seated Physical Activity INtervention(SPIN) for Wheelchair Users With Multiple Sclerosis
The purpose of this study is to assess changes in the outcome of exercise behavior between the SPIN exercise-training condition and the WEllness for Longevity Living (WELL) attention/contact wellness control condition and to…
- Trial name
- SPIN (NCT07891520)
- Testing
- SPIN exercise-training, Control Condition (WELL)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epigenetic Aging
Effects of Switch to Doravirine/Islatravir vs. Continued Antiretroviral Therapy on Biomarkers of Aging Among Virologically Suppressed People With HIV
The purpose of this study is to quantify biologic aging (using validated epigenetic clocks) as downstream indicators of Long Interspersed Nuclear Element-1 (LINE-1) retrotransposon activity before and after switch to doravirine…
- Trial name
- DELILAH (NCT07871552)
- Testing
- Switch from an ART regimen containing lamivudine (3TC) or emtricitabine (FTC) + tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) to DOR/ISL, Switch from an nucleoside reverse transcriptase inhibitor (NRTI)-sparing ART regimen containing greater than or equal to 2 drugs to DOR/ISL, Continue SoC ART
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia…
- Trial name
- NCT06739356
- Testing
- Fetal Treatment arm (FETO Group)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Neuropathic Pain
BreEStim Pre-trial
The overall goal is to evaluate the effectiveness of different stimulation protocol of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) in managing neuropathic pain after spinal cord injury (SCI).
- Trial name
- NCT07878429
- Testing
- Single-pulse BreEStim Treatment, Multiple-pulse BreEStim Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Firearm Injury
Launching the Houston Hospital-Based Violence Intervention Program (Houston-HVIP): Developing and Evaluating a Hospital-Based Intervention to Reduce Recurrent Violence
A prior violent injury is one of the strongest predictors of future violent injury, highlighting the importance of effective hospital-based interventions to prevent reinjury.
- Trial name
- NCT06263647
- Testing
- Houston-HVIP treatment, Standard of Care
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain Management
BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management…
- Trial name
- NCT07659743
- Testing
- Active BreEStim Treatment, The TENS Treatment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The University of Texas Health Science Center, Houston
Axial Spondyloarthritis (AxSpA)
A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis
The purpose of this study is to determine the feasibility of conducting a pragmatic trial of IL-17i versus JAKi in adults with axial spondyloarthritis (axSpA) who have failed at least one tumor necrosis factor-alpha inhibitor…
- Trial name
- NCT07770646
- Testing
- Secukinumab (IL-17i ), Upadacitinib (JAKi)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy Adult Participants
Neuroanatomically Informed fMRI Neurofeedback in Healthy Adults
This study will test and refine a type of brain training called functional magnetic resonance imaging (fMRI) neurofeedback in healthy adults.
- Trial name
- NCT07873710
- Testing
- Functional Connectivity fMRI Neurofeedback, ROI-Activity fMRI Neurofeedback
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Physical Activity
Evaluating an Implementation Strategy to Improve Physical Activity and Reduce Cardiovascular Risk Factors in Children
The purpose of this study is to evaluate the impact of enhanced Movement for Academic Growth In Classrooms (MAGIC) for improving implementation and effectiveness of physically active breaks, lessons, and motor labs
- Trial name
- NCT07541118
- Testing
- MAGIC, Control
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic…
- Trial name
- NCT04677751
- Testing
- Acupuncture intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Allergic Contact Dermatitis (ACD)
Use of Silk Fibroin Dressings in Primary Total Hip Arthroplasty
The purpose of this study is to document the incidence of allergic contact dermatitis (ACD) to silk fibroin and 2-octyl cyanoacrylate mesh dressings, to document the incidence of acute wound dehiscence requiring reoperation after…
- Trial name
- NCT07868900
- Testing
- Dermabond PRINEO, Silk fibroin
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pancreatic Ductal Adenocarcinoma
Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma
The purpose of this study is to perform a pilot phase II trial to evaluate the safety and efficacy of combined EUS-RFA, chemotherapy, and systemic immunotherapy (pembrolizumab) for the treatment of locally advanced unresectable…
- Trial name
- PANCARDINAL-2 (NCT06831136)
- Testing
- Neoadjuvant Chemotherapy (NAC), Immunotherapy (pembrolizumab), Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cluster Headache
Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache
The purpose of this study is to assess headache response rate for minimal pain at 30 minutes following zavegepant administration and to assess additional effectiveness and treatment failure endpoints at various timepoints after…
- Trial name
- NCT07714369
- Testing
- Zavegepant 20 mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Circadian Variation in Anti-Factor Xa (Anti-FXa) Activity
Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients
The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis
- Trial name
- NCT07856641
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Surgery
Ultrasound Evaluation for Improving Patient Selection in vNOTES
Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is an emerging field in minimally invasive surgery. An international consensus-based statement was recently published to help guide the basis for adopting vNOTES…
- Trial name
- PUP-VNOTES (NCT05623514)
- Testing
- Trans-vaginal ultrasound
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston