Clinical trials: sponsored by National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease
Coronary Drug Project
To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result in significant reduction in total mortality…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000482
- Testing
- estrogen, clofibrate clofibrate, dextrothyroxine sodium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Randomized Trial of Dietary Intervention Therapy in Obese Hypertensives (DITOH)
To determine the effects on blood pressure of dietary intervention, restricting caloric intake to 600 calories per day for 16 weeks compared to a control diet of 1200 calories per day in obese hypertensives.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
- Trial name
- NCT00000515
- Testing
- diet, reducing
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Angina, Unstable, Cardiovascular Diseases
Unstable Angina Pectoris Trial
To compare the efficacy of medical or surgical (coronary artery bypass graft) therapy with regard to survival and quality of life in patients with unstable angina and requisite coronary anatomy as defined by angiography.
- Conditions
- Angina, Unstable, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00000486
- Testing
- coronary artery bypass
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Diseases, Obesity
Cardiovascular System in Obesity: Effect of Treatment
To determine the long-term efficacy of the combination therapy of phentermine and fenfluramine in conjunction with diet, exercise, and behavior modification in the treatment of simple, moderate obesity.
- Conditions
- Heart Diseases, Obesity, Vascular Diseases
- Trial name
- NCT00000506
- Testing
- fenfluramine, phentermine
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Blood Transfusion, Infection
Granulocyte Transfusion Study
To evaluate granulocyte transfusion therapy with respect to its prophylactic and therapeutic effectiveness to prevent and aid recovery from infection. The study trials were conducted simultaneously.
- Trial name
- NCT00000581
- Testing
- leukocyte transfusions
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Diseases, Pulmonary Fibrosis
Diffuse Fibrotic Lung Disease
To determine the effects of cyclophosphamide compared with prednisone, dapsone, or high-dose intermittent 'pulse' therapy with methylprednisolone in patients with idiopathic pulmonary fibrosis.
- Conditions
- Lung Diseases, Pulmonary Fibrosis, Sarcoidosis
- Trial name
- NCT00000596
- Testing
- prednisone, cyclophosphamide, dapsone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia (Iron-Loading), Beta-Thalassemia
Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis
To determine whether deferoxamine prevented the complications of transfusional iron overload.
- Conditions
- Anemia (Iron-Loading), Beta-Thalassemia, Hematologic Diseases, Hemoglobinopathies
- Trial name
- NCT00000595
- Testing
- deferoxamine
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia, Aplastic, Hematologic Diseases
Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders
To determine the therapeutic effects of anti-thymocyte globulin (ATG) in patients with aplastic anemia and related bone marrow failure diseases.
- Conditions
- Anemia, Aplastic, Hematologic Diseases, Pancytopenia, Blood Disease
- Trial name
- NCT00000597
- Testing
- antilymphocyte serum, nandrolone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Leukemia
Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia
RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral stem cell transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00066417
- Testing
- cyclophosphamide, cyclosporine, fludarabine phosphate
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Diseases, Respiratory Distress Syndrome
Prevention of Neonatal Respiratory Distress Syndrome With Antenatal Steroid Administration
To determine the effect of corticosteroids, administered 24 to 48 hours before parturition, on the incidence of neonatal respiratory distress syndrome (RDS) and to determine whether the therapy has any adverse short- or long-term…
- Trial name
- NCT00000563
- Testing
- dexamethasone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Blood Coagulation Disorders, Hematologic Diseases
Cooperative Study of Factor VIII Inhibitors
To test the efficacy of prothrombin complex concentrates (Factor IX) in the treatment of hemophiliac patients who had inhibitors to Factor VIII.
- Conditions
- Blood Coagulation Disorders, Hematologic Diseases, Hemophilia A, Hemorrhagic Disorders
- Trial name
- NCT00000582
- Testing
- factor ix
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Arrhythmia, Cardiovascular Diseases
Cardiac Arrhythmia Pilot Study (CAPS)
To compare the effectiveness of various drugs and drug combinations in suppressing complex ventricular arrhythmias, and to evaluate their safety.
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Diseases, Ventricular Arrhythmia
- Trial name
- NCT00000504
- Testing
- encainide, moricizine, flecainide
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease
NHLBI Type II Coronary Intervention Study
To determine whether lowering of cholesterol with cholestyramine in a population with Type II hyperlipidemia led to a decreased rate of progression (a regression of coronary artery disease) as demonstrated by death, myocardial…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypercholesterolemia, Familial
- Trial name
- NCT00000594
- Testing
- cholestyramine
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Defects, Congenital, Heart Failure, Congestive
Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network
This study will evaluate the efficacy and safety of administering an angiotensin converting enzyme inhibitor (ACE-I) (enalapril) to infants with a functional single ventricle.
- Trial name
- ISV (NCT00113087)
- Testing
- Enalapril
- Where
- 9 sites in United States, Canada
- Volunteers
- 230 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lymphangioleiomyomatosis, Lymphangiomyomas
Treatment With Octreotide in Patients With Lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM), a disease primarily of women of child-bearing age, is characterized by cystic lung disease and abdominal tumors (e.g., angiomyolipomas).
- Conditions
- Lymphangioleiomyomatosis, Lymphangiomyomas, Pleural Effusions, Ascites
- Trial name
- NCT00005906
- Testing
- Octreotide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sleep Disorders, Circadian Rhythm
Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders
Jet lag and some sleep disorders are caused by a disruption in an individual's "internal clock." Understanding the most effective way to quickly re-adjust the body's internal clock will be beneficial for treating individuals with…
- Trial name
- NCT00387179
- Testing
- Melatonin, Methylxanthine, Light Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Overweight and Obesity, Insulin Resistance
DHA Supplements to Improve Insulin Sensitivity in Obese Pregnant Women (The Omega-3 Pregnancy Study)
Women with excess adiposity while pregnant are more likely to develop gestational diabetes and high blood pressure during pregnancy than women of healthy weights.
- Conditions
- Overweight and Obesity, Insulin Resistance, Diabetes, Gestational, Hypertension in Pregnancy
- Trial name
- NCT00865683
- Testing
- DHA Supplements
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease
National Health and Nutrition Examination Survey IV (NHANES (IV)
To supplement the fourth National Health and Nutrition Examination Survey protocol to include data on the common heart, vascular, lung, and blood diseases.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005154
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tuberculosis
Effectiveness of the TB Contact Priority Model
The broad purpose of this project, proposed by investigators at the University of Alabama at Birmingham and the State of Alabama Department of Public Health, is to use a behaviorally focused education that has been proven…
- Trial name
- NCT00149448
- Testing
- TB Contact Priority Model
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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