Clinical trials: sponsored by NYU Langone Health
Osteoarthritis
Oral Nutritional Optimization in Total Joint Arthroplasty
The purpose of this study is to determine the effect on hematological markers of nutritional intervention on nutritionally deficient patients following total joint replacement surgery.
- Trial name
- NCT04210284
- Testing
- Ensure
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- NYU Langone Health
Cochlear Implant Users
Cochlear Implants and Listening Effort: the Interaction of Cognitive and Sensory Constraints
This study examines how cochlear implant users understand and comprehend speech in realistic communication situations. Through six experiments measuring listening effort via pupillometry and discourse comprehension, we will…
- Trial name
- NCT07279441
- Testing
- Experiment 1: Syntactic and Semantic Context, Experiment 2: False Hearing and Context Overuse, Experiment 3: Two-Sentence Problem
- Where
- 2 sites in United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Deafness
Investigating Auditory Processing in the Users of Auditory Brainstem and Cochlear Implants
This is a basic investigational research study conducted with hearing impaired adults and children who use cochlear implant or auditory brainstem implant (ABI) devices.
- Trial name
- NCT05810220
- Testing
- Electrode-Neural Interface
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Heart Disease
Evaluation of Cardiac Function With Cardio-respiratory Synchronized MRI
The purpose of this investigation is to evaluate newer methods of performing cardiovascular MRI (CMR) that will provide new kinds of information related to the interplay between the cardiac and the respiratory cycles, such as the…
- Trial name
- NCT02728284
- Testing
- cardiovascular MRI (CMR), Conventional Cardiologic Evaluation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Chronic Kidney Diseases
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)
30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in…
- Trial name
- NCT06927024
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Obesity
The Sleep and Weight Study
The purpose of this pilot study is to examine the implementation of a combined intervention targeting food cravings and sleep for adults with obesity in clinical settings.
- Trial name
- NCT07904663
- Testing
- Food Craving app, Sleep Coach app
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Vaccine Reaction
Understanding Poor Vaccine Responses to Hepatitis B Vaccination
Vaccines have prevented countless infections but poor vaccine responses remain a major challenge in many scenarios. Hepatitis B vaccine nonresponses are common but immunologically not well-understood.
- Trial name
- NCT04674462
- Testing
- CpG-adjuvanted HBV Vaccine, Traditional HBV Vaccine
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mild Cognitive Impairment, Alzheimer Disease
Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)
This multi-site study will be the first to evaluate the dose-dependent effects of t-PBM in amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD) (CDR of 0.5-1, FAST 1-4; age 65-85) in a randomized clinical…
- Trial name
- NCT04784416
- Testing
- Active tPBM-2.0, 18F-MK-6240
- Where
- 3 sites in United States
- Volunteers
- 196 people
- Sponsor
- NYU Langone Health
Hip Fracture Surgeries, Intertrochanteric Fracture
Monitored Anesthesia Care and Soft Tissue Infiltration With Local Anesthesia Feasibility Trial
The purpose of this study is to establish preliminary efficacy of Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia (MAC-STILA) on severity of post operative delirium and secondary outcomes in patients…
- Conditions
- Hip Fracture Surgeries, Intertrochanteric Fracture, Femoral Hip Fracture
- Trial name
- MAC-STILA (NCT07897656)
- Testing
- Monitored Anesthesia Care (MAC), Soft Tissue Infiltration with Local Anesthetic (STILA), General Anesthesia
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- NYU Langone Health
Systemic Lupus Erythematosus
Safety of the Herpes Zoster Subunit Vaccine in Lupus
This randomized, double-blind, placebo-controlled, non-inferiority crossover study will evaluate the Herpes Zoster Sunbit (HZ/su) vaccine in SLE patients in order to evaluate safety and immunogenicity in patients with variable…
- Trial name
- NCT05559671
- Testing
- Herpes Zoster Subunit (HZ/su) Vaccine
- Where
- 2 sites in United States
- Volunteers
- 224 people
- Sponsor
- NYU Langone Health
Type 1 Diabetes
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any…
- Trial name
- CHORD1 (NCT05641753)
- Testing
- Evolocumab Cartridge, Atorvastatin Calcium Tablets, Ezetimibe Tablets
- Where
- 4 sites in United States
- Volunteers
- 125 people
- Sponsor
- NYU Langone Health
Cardiovascular Health
Generations for Heart Health
Heart disease is the leading cause of death for women in the United States, and many women find it hard to prioritize their own health while caring for family.
- Trial name
- NCT07901439
- Testing
- Activity Tracker, Text Messages
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Melanoma, Unresectable Melanoma
Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
This study will evaluate how safe the study drug is, how well patients tolerate it, how it works in the body, and the disease's response to the drug.
- Trial name
- NCT05428007
- Testing
- Sarilumab, Ipilimumab Injection, Nivolumab/Relatlimab
- Where
- 4 sites in United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Pulmonary Embolism
Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy
PE-TRACT is an open-label, assessor-blinded, randomized trial, aiming to compare catheter-directed therapy (CDT) and anticoagulation (CDT group) with anticoagulation alone (No-CDT) in 500 patients with submassive PE, proximal…
- Trial name
- PE-TRACT (NCT05591118)
- Testing
- Anticoagulant Therapy, Catheter-Directed Therapy
- Where
- 40 sites in United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Population Health
The Young Adults' Experiences With Virtual Reality (YAES VR) Study
The purpose of this study is to test the effect of virtual reality (VR) food marketing exposure (versus VR non-food control) on snack consumption, purchase intention, hunger, and arousal in black and white young adults.
- Trial name
- NCT06917391
- Testing
- Wendyverse VR food marketing experience, Nikeland VR non-food marketing experience
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Body Weight
Body Weight, Aspirin Dose and Pro-resolving Mediators
This study employs a placebo-controlled randomized cross-over design to investigate the impact of body weight and aspirin dose on levels of specialized pro-resolving lipid mediators in blood and neutrophils.
- Trial name
- NCT04697719
- Testing
- Aspirin 81mg, Aspirin 325mg
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Care in Multiple Sclerosis (MS)
This study is structured around three main aims. In Aim 1, investigators will conduct community-based participatory research (CBPR) to develop culturally tailored methods to assess childhood adversity in multiple sclerosis (MS).
- Trial name
- NCT07011914
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- NYU Langone Health
Metastatic Clear Cell Renal Cell Carcinoma
Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)
The purpose of this study is to identify changes in Carbonic Anhydrase IX (CAIX) expression induced by hypoxia-inducible factor 2 alpha (HIF-2α) inhibition by initiating belzutifan single agent therapy and imaging CAIX expression…
- Trial name
- NCT07179770
- Testing
- Belzutifan, 89Zr-DFO-girentuximab, 89Zr-DFO-girentuximab PET
- Where
- United States
- Sponsor
- NYU Langone Health
Acute Kidney Injury (AKI), Postnatal AKI
NIRS Monitoring in the NICU and AKI
The primary objective of this study is to describe the pattern of renal tissue oxygen saturation (SrSO2) using near-infrared spectroscopy (NIRS) in premature infants <30 weeks gestational age.
- Trial name
- NCT07222722
- Testing
- NIRS Monitoring
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Prostate Adenocarcinoma
SURPASS: Stereotactic Ultra-hypofractionated Radiotherapy for Post-prostatectomy Patients: Adaptive Salvage SBRT
The purpose of the study is to evaluate the safety and feasibility of daily-adaptive post-prostatectomy stereotactic body radiotherapy (SBRT) to the prostate fossa in men undergoing salvage radiotherapy after radical…
- Trial name
- NCT07888283
- Testing
- Adaptive stereotactic body radiotherapy (SBRT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
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