Clinical trials: sponsored by Mayo Clinic
Amyloidosis
A Study Of MCG In Cardiac Amyloidosis
The primary objective of this observational study is to evaluate the utility of magnetocardiography (MCG) in diagnosing and monitoring disease progression in patients with amyloidosis, and to assess its effectiveness in…
- Trial name
- NCT07218705
- Testing
- SandboxAQ CardiAQ Magnetocardiography
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Mechanical Ventilation
Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure
The purpose of this research is to evaluate a different way of using the mechanical ventilator device to help better protect the lungs while the patient recovers.
- Trial name
- NCT07294768
- Testing
- VentCoach, Standard of Care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Endometrial Carcinoma
Targeting Inflammation for Endometrial Cancer Prevention
This study examines risk assessment and identifies prevention strategies for endometrial cancer. Collecting samples of blood and urine and risk assessments from patients with benign conditions or endometrial cancer may help…
- Trial name
- NCT05407025
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Monoclonal Gammopathy of Undetermined Significance (MGUS), Non-IgM Monoclonal Gammopathy of Undetermined Significance
A Study of Carbon 13-based Deep Labelling of Bone Marrow Cells
This study evaluates a novel laboratory method to study how certain bone marrow cells in the body take up nutrients from their environment.
- Trial name
- NCT07057583
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
IBS - Irritable Bowel Syndrome, Diarrhea
Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator
The purpose of this research is to study the added benefit of treating IBS symptoms with a medication called mirtazapine in treating IBS symptoms when paired with a low-FODMAP diet compared to a low-FODMAP diet alone.
- Trial name
- NCT06684470
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic
Growth Plate Injury
Molecular Modulation of the Growth Plate
The researchers are trying to identify molecular mechanisms that control growth plate mediated limb growth and identify agents that can be used to enhance or slow growth.
- Trial name
- NCT03501589
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Arthropathy of Knee
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
- Trial name
- NCT03598829
- Testing
- Tryptase, Serum test
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Mayo Clinic
Functional Neurological Disorder
Demonstrating Efficacy of JOGO for the Treatment of Tremor
This research is being done to determine the effectiveness of a new treatment, called JOGO, for patients with functional tremor (FT).
- Trial name
- NCT06346873
- Testing
- JOGO
- Where
- United States
- Sponsor
- Mayo Clinic
Kidney Transplant Recipients
Envarsus XR Compared to Immediate Release Tacrolimus
The purpose of this study is to compare once-daily tacrolimus extended-release (Envarsus XR®) to twice-daily immediate release tacrolimus to find out if people taking tacrolimus extended release (Envarsus XR®) report fewer side…
- Trial name
- SIMPLE (NCT03979365)
- Testing
- Envarsus XR, Tacrolimus twice daily
- Where
- 3 sites in United States
- Volunteers
- 261 people
- Sponsor
- Mayo Clinic
Prostate Cancer, Prostate Adenocarcinoma
Focal Laser Ablation of Low to Intermediate Prostate Cancer Tumors
The primary purpose of this study is to evaluate the feasibility and safety of MRI-guided focal laser ablation (Laser-Induced Interstitial Thermal Therapy, LITT) to treat low-risk native prostate cancer.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
- Trial name
- NCT02600156
- Testing
- Focal laser ablation of the prostate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Recurrent Cholecystitis, Cholecystitis
One vs. Two Stents for Gallbladder Disease
This randomized trial will look at whether placing two cystic duct stents is more effective than one cystic duct stent in preventing recurrent gallbladder disease (cholecystitis, gallstone pancreatitis, or biliary colic) among…
- Conditions
- Recurrent Cholecystitis, Cholecystitis, Symptomatic Gallbladder Disease, Biliary Colic
- Trial name
- NCT07222527
- Testing
- ERCP with one stent placement, ERCP with two stent placement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Delirium on Emergence
Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium
The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.
- Trial name
- NCT06624592
- Testing
- Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Amyotrophic Lateral Sclerosis
Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders
The purpose of this study is to collect CSF and blood samples that can be used in future research studies to identify potential biomarkers in blood and cerebrospinal fluid (CSF) collected in Amyotrophic Lateral Sclerosis (ALS)…
- Trial name
- NCT05116943
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pancreaticoduodenectomy
Paravertebral Block vs no Block in Open Pancreaticoduodenectomy
The purpose of this study is to compare intra and postoperative pain control between Paravertebral block vs no block in open pancreaticoduodenectomy. Length of stay, and complications will also be recorded.
- Trial name
- NCT05820997
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Undiagnosed Disease, Rare Diseases
Rare and Undiagnosed Disease Research Biorepository
This research study is being done to find markers and identify causes of rare and undiagnosed diseases by analyzing patient's DNA (i.e., genetic material), RNA, plasma, urine, tissues, or other samples that could be informative…
- Trial name
- PRaUD (NCT04703179)
- Testing
- Genetic test evaluation
- Where
- 3 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prostate Adenocarcinoma, Prostate Carcinoma
DNA Methylation in Adenocarcinoma of the Prostate: Analysis of Validated Biomarkers in Urine
This study explores the potential use of DNA markers in the detection of prostate cancer and patient perceptions of this screening approach and other current or future prostate cancer screening and diagnostic tests.
- Trial name
- NCT06347809
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
PreDiabetes
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1.
- Trial name
- NCT06967558
- Testing
- Exendin 9-39, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Resistance Training
Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity
To uncover the underlying mechanisms of resistance exercise training benefits on glucose metabolism and insulin sensitivity in muscle.
- Trial name
- NCT07128368
- Testing
- Resistance Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2, Diastolic Dysfunction
PDD in Type 2 Diabetes w/wo Diastolic Dysfunction
This study will advance the investigator's knowledge of the integrated cardiorenal and humoral physiology in type 2 diabetic patients with and without pre-clinical diastolic dysfunction, and test a novel therapeutic strategy…
- Trial name
- NCT03744975
- Testing
- LCZ 696
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.