Clinical trials: sponsored by Fudan University
High-Risk Localized Soft Tissue Sarcoma
The Combination of Radiotherapy，Surufatinib and Sintilimab in High-Risk Localized Soft Tissue Sarcoma
This is a prospective, single-center, single-arm, phase Ib/II clinical trial. The study aims to evaluate the safety and efficacy of the treatment which combines radiotherapy, Sintilimab (Anti-PD1 Antibody) and Surufatinib…
- Trial name
- IRIS (NCT05839275)
- Testing
- Surufatinib, Sintilimab, Radiotherapy
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Fudan University
Biliary Atresia Congenital Type 3
A Peer Support Network System Construction for the Primary Caregivers of Children With Biliary Atresia
The peer support WeChat platform for primary caregivers of children with biliary atresia can provide social support ,help them adopt positive coping styles to face the disease, and reduce negative emotions and caregiver burden.
- Trial name
- NCT05503394
- Testing
- Peer support WeChat platform intervention, Routine nursing care group
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Children's Hospital of Fudan University
Incisional Hernia, Recurrent Hernia
Pulmonary Ventilation Function Between Patients With Primary and Recurrent Incisional Hernia: a Cross-sectional Study
Purpose Chronic obstructive pulmonary disease (COPD) is a risk factor for incisional hernia, COPD has persistent airflow restriction and pulmonary ventilation dysfunction.
- Conditions
- Incisional Hernia, Recurrent Hernia, COPD, Pulmonary Ventilation Function
- Trial name
- NCT05991024
- Testing
- the incisional hernia recurrent
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Fudan University
Hemodynamics
Comparison of Esketamine-Propofol and Fentanyl-Propofol
Propofol is widely used as an induction agent during general anesthesia. The prevalent induction dose may be associated with unacceptable cardiovascular instability, especially in elderly patients.The combination of ketamine and…
- Trial name
- NCT05752409
- Testing
- The median dose of esketamine, The high dose of esketamine, Propofol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Very Low Birth Weight Infant
The Effect of Family Integrated Care on Melatonin Level in Very Low Birth Weight Infants
This study will explore the effect of Family integrated care (FICare) on the level of melatonin and other clinical outcomes in very low birth weight infants (VLBWIs) by integrating families into the neonatal intensive care unit…
- Trial name
- NCT05483231
- Testing
- Family integrated care intervention group, Routine nursing care group
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Children's Hospital of Fudan University
Differentiated Thyroid Cancer
Surufatinib as Neoadjuvant Treatment for Locally Advanced or Metastatic Differentiated Thyroid Cancer
Locally advanced thyroid cancer has a wide range of surgery, large trauma and high local recurrence rate. It is one of the main causes of death in patients with thyroid cancer.
- Trial name
- NCT05989425
- Testing
- surufatinib
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Fudan University
Premature Infants
Shorten the Time Required to Correct the Arrival of Complete Oral Feeding in Premature Infants
Non-nutritive sucking combined with a step-by-step oral feeding regimen shortens the total oral feeding cycle in premature infants
- Trial name
- NCT05208437
- Testing
- Complete oral feeding intervention, Routine nursing care group
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Children's Hospital of Fudan University
HER2-positive Gastric Cancer, Immunotherapy
Disitamab Vedotin, Fruquintinib and Tislelizumab in Second-line Treatment for HER2-positive MGC
At present, there is no anti-HER2 therapy recommended by guidelines for second-line treatment of advanced gastric cancer with HER2-positive or HER2-overexpression, and combined with anti-angiogenic drugs are mainly used.
- Trial name
- NCT05982834
- Testing
- Disitamab Vedotin combined with fruquintinib and Tislelizumab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fudan University
Hypopharyngeal Carcinoma, Immunotherapy
Induction Chemotherapy Combined With Immunotherapy for Locally Advanced Hypopharyngeal Carcinoma
This is a single-center, multidisciplinary, open-label, single-arm prospective clinical study.
- Conditions
- Hypopharyngeal Carcinoma, Immunotherapy, Chemotherapy
- Trial name
- NCT04156698
- Testing
- Docetaxel, Cisplatin, Capecitabine
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Gastric Cancer, Chemotherapy Effect
Sintilimab Combined With Modified FLOT Regimen in the Treatment of Metastatic Gastric Cancer
This is a prospective, one-arm, single-center phase II study. The objective was to evaluate the efficacy and safety of domestic PD-1 antibody Sintilimab combined with modified FLOT regimen in the treatment of metastatic gastric…
- Conditions
- Gastric Cancer, Chemotherapy Effect, Immune Checkpoint Inhibitor
- Trial name
- NCT05982301
- Testing
- Sintilimab, paclitaxel-albumin, oxaliplatin, 5-FU
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fudan University
Ovarian Cancer
Circulating Tumor DNA Monitoring in Platinum-resistant Ovarian Cancer
This observational study is conducted to assess the utility of circulating tumor DNA in monitoring the response to pegylated liposomal doxorubicin in platinum-resistant ovarian cancer，and evaluate the consistency of circulating…
- Trial name
- NCT05976932
- Testing
- pegylated liposomal doxorubicin
- Volunteers
- 20 people
- Sponsor
- Fudan University
Esophageal Squamous Cell Carcinoma
Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma
The purpose of this study is to determined the best definitive radiotherapy dosage for patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT03790553
- Testing
- Radiotherapy
- Where
- 3 sites in China
- Volunteers
- 646 people
- Sponsor
- Fudan University
Esophagus Cancer, Esophageal Squamous Cell Carcinoma
Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shanghai 17)
The purpose of this study is to evaluate safety and 2-year local control rate for postoperative concurrent chemoradiotherapy for esophageal squamous cell carcinoma.
- Conditions
- Esophagus Cancer, Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Radiation Therapy
- Trial name
- NCT04764227
- Testing
- Paclitaxel, Carboplatin, Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Fudan University
Financial Toxicity
A Longitudinal Study of the Trajectory of Financial Toxicity and Its Relationship With Symptom Burden in Breast Cancer Patients
Breast cancer has become the leading cause of global cancer incidence. With the improvement of treatment methods, some breast cancer patients have experienced different degrees of financial toxicity, which seriously affected the…
- Trial name
- NCT05964816
- Where
- 4 sites in China
- Volunteers
- 485 people
- Sponsor
- Fudan University
Pancreatoduodenectomy, Periampullary Carcinoma
Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy
Aim of the study : To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary…
- Conditions
- Pancreatoduodenectomy, Periampullary Carcinoma, Pancreatic Cancer
- Trial name
- NCT05703581
- Testing
- TRIANGLE operation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Metastatic Colorectal Cancer
Regorafenib Combined With TAS-102 Versus Regorafenib Monotherapy in Third or Later Line Therapy of mCRC
The purpose of this study is to evaluate the clinical benefit of regorafenib combined with TAS-102 compared with regorafenib monotherapy in patients with metastatic colorectal cancer who have failed at least two lines of…
- Trial name
- NCT05970705
- Testing
- Regorafenib, Trifluridine/Tipiracil
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Fudan University
Metastatic Esophageal Squamous Cell Carcinoma
A Study of IO Plus Radiotherapy in Patients With Advanced ESCC.
This study is a single-arm, prospective, phase II trial for patients with metastatic esophageal squamous cell carcinoma (ESCC) who received immunotherapy plus chemotherapy as the first-line treatment.
- Trial name
- NCT05760391
- Testing
- Radiotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1015)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1015). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794711
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1016)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1016). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794724
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Carcinoma, Non-Small-Cell Lung
ELobectomy for NSCLC by VATS Versus Thoracotomy (ECTOP-1007)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1007). The goal of this study is to determine video-assisted thoracoscopic surgery is non-inferior to thoracotomy in terms of disease-free survival for…
- Trial name
- NCT03786003
- Testing
- VATS, Thoracotomy
- Where
- China
- Volunteers
- 1,086 people, healthy volunteers welcome
- Sponsor
- Fudan University
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