Clinical trials: open to volunteers, sponsored by Chinese University of Hong Kong
HCC
SBRT With Immunotherapy and Atezo-Bev in HCC With Major Portal Vein Thrombosis
Patients with PVTT involvement is a significant healthcare burden as they are present in up to 40% of patients with HCC at diagnosis.
- Trial name
- NCT06823375
- Testing
- Radiotherapy, Atezolizumab plus Bevacizumab
- Where
- 2 sites in Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Musculoskeletal Diseases or Conditions
ITPB 1 vs 3 in VATS
This study aims to evaluate the quality of recovery after video-assisted thoracoscopic surgery (VATS) by comparing the efficacy of a single-level intertransverse process block (ITPB) against a three-level ITPB, with particular…
- Trial name
- NCT06838793
- Testing
- Single Level Intertransverse Process Block, Three Level Intertransverse Process Block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Musculoskeletal Diseases or Conditions
Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block
The objective of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug "levobupivacaine" required to produce an effective ultrasound guided (USG) superior trunk block (STB) in at least…
- Trial name
- NCT04941664
- Testing
- 0.5% levobupivacaine
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- Chinese University of Hong Kong
Musculoskeletal Diseases or Conditions
Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block
Sciatic nerve block at the popliteal fossa is indicated for foot or ankle surgery, and the introduction of ultrasound guidance (USG) has improved the ease and accuracy of the performance of this block.
- Trial name
- NCT04397484
- Testing
- 0.5% Levobupivacaine, 2% Xylocaine with adrenaline 1:200,000
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Postpartum Exercise, Cardiometabolic Health
Exercise to Improve Heart and Metabolic Health After Childbirth in Women at High Risk for Preeclampsia
Women who develop hypertensive disorders of pregnancy have an increased risk of cardiovascular disease later in life. Whether exercise during the postpartum period improves cardiometabolic health in this population remains…
- Conditions
- Postpartum Exercise, Cardiometabolic Health, High Risk for Preeclampsia, Randomized Controlled Trial
- Trial name
- NCT07921173
- Testing
- Postpartum Exercise Program
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Musculoskeletal Diseases or Conditions
Sensorimotor Block Dynamics and Hemidiaphragmatic Palsy: Selective Trunk Block vs Supraclavicular Brachial Plexus Block
Ultrasound guided supraclavicular brachial plexus block (BPB) has been extensively studied and recommended as a sole anesthetic for upper extremity surgeries.
- Trial name
- NCT05649644
- Testing
- Selective Trunk Block (SeTB), Supraclavicular Brachial Plexus Block (SC BPB)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
A Multi-centre Trial on Targeted Microwave Ablation (TMA) for Localized Prostate Cancer: The VIOLETTA Trial
This study is to investigate the efficacy of Targeted Microwave Ablation (TMA) under MRI-Ultrasound fusion and organ-based tracking (OBT) navigation in localized prostate cancer (PCa) in a multi-centre trial.
- Trial name
- NCT06262633
- Testing
- Targeted Microwave Ablation (TMA) for localized prostate cancer using organ based tracking (OBT) navigation
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- Chinese University of Hong Kong
Acute Heart Failure (AHF)
Comprehensive Clinical Prediction Rule for Acute Heart Failure
The goal of this prospective observational cohort study is to establish a comprehensive clinical prediction rule integrating clinical characteristics, point-of-care testing (POCT) of NT-proBNP, an 8-point LUS, and a rapid cardiac…
- Trial name
- NCT07754084
- Testing
- Acute Heart Failure Diagnostic Method
- Where
- 3 sites in Hong Kong
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Meniscal Tears
Effects of Pulsed Electromagnetic Field Therapy on Meniscal Healing, Symptom Relief, and Knee Function
The goal of this clinical trial is to learn if pulsed electromagnetic field (PEMF) combined with home exercise improves healing and function in adults with meniscus tears. The main questions it aims to answer are: 1.
- Trial name
- NCT07117929
- Testing
- Active PEMF, Exercise
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Chinese University-Alzheimer's Disease With Vascular and Other Co-pathology: Towards Actionable Neuro-Cognitive-Omic Evaluations (CU-ADVANCE)
Population aging is transforming the epidemiological landscape of the Asia-Pacific region at an unprecedented pace. By 2050, more than one quarter of the region's population will be aged over 60, with 36.7% of countries projected…
- Trial name
- NCT07917182
- Where
- China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Behavior
A Chatbot to Reduce Chemsex and HIV-related Risk Behaviors Among Men Who Have Sex With Men
The goal of this clinical trial is to investigate whether receiving chatbot-delivered stage-of-change-tailored online interventions is effective in reducing chemsex among men who have sex with men in Hong Kong.
- Trial name
- NCT07472582
- Testing
- Chatbot-delivered online interventions and online videos, Online videos only
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
Performance, Feasibility, and Safety Study for a Novel Endoluminal Robotic System for En-Bloc Resection of Bladder Tumours: First-In-Human Trial
This is a prospective, single-arm study to evaluate the feasibility and safety of performing transurethral en-bloc resection of bladder tumours using the Zenith robotic system.
- Trial name
- NCT06281080
- Testing
- En-Bloc Resection of Bladder Tumours
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
BPH
Blue Diode Laser Vaporization for BPH
This is a prospective data collection of subjects using blude diode laser for the treatment of BPH.
- Trial name
- NCT07115147
- Testing
- Blue diode laser
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Idiopathic Parkinson Disease
Non-invasive Vagus Nerve Stimulation for Parkinson's Disease
Although breakthroughs in the management of Parkinson's disease (PD) have emerged in recent decades resulting in better control in symptoms, majority of patients with PD are still living with various disabling motor and non-motor…
- Trial name
- VNS (NCT07908498)
- Testing
- cVNS, eVNS, sVNS
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Artificial Intelligence (AI)-Assisted Risk-based Prostate Cancer Detection
This is a prospective clinical study recruiting 510 men at risk of PCa to undergo urine, blood, AI-assisted ultrasound and AI-assisted MRI investigations to stratify risk of clinically significant PCa (csPCa).
- Trial name
- NCT05443412
- Testing
- Diagnostic test for prostate cancer
- Where
- Hong Kong
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence
It is a prospective paired-cohort study for diagnostic test evaluation. The study aim to determine the accuracy of AI review and investigate whether AI review could detect MRI visible significant cancer as effective as…
- Trial name
- NCT06360523
- Testing
- AI modal, Standard review
- Where
- Hong Kong
- Volunteers
- 629 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthristis
Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list
Total knee arthroplasty (TKA) is a cost effective solution for people with end-stage knee osteoarthritis. Given Hong Kong's large senior population and age as the primary risk factor for osteoarthritis, waiting times for total…
- Trial name
- NCT07912333
- Testing
- Wearable Device, Control
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- Chinese University of Hong Kong
Thyroid Nodule (Diagnosis)
Ultrasound-guided Microwave Ablation of Benign Thyroid Nodules
The goal of this clinical trial is to learn if microwave ablation of benign thyroid nodules under local anaesthesia is a safe and effective procedure compared to open thyroidectomy.
- Trial name
- NCT07906821
- Testing
- ultrasound-guided percutaneous microwave ablation (MWA)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Renal Tumors
The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)
This is a prospective single-center, single-arm, feasibility trial designed to evaluate the safety of the HistoSonics Histotripsy System for treatment of renal tumors.
- Trial name
- NCT07911527
- Testing
- HistoSonics® Edison System (US)
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
The Role of ERBT Plus Adjuvant Intravesical Induction and Maintenance Chemotherapy for Intermediate-Risk NMIBC
This is a prospective, multi-centre randomised trial comparing between ERBT plus 1-year of Ad-MMC, versus ERBT alone, in treating intermediate-risk NMIBC.
- Trial name
- NCT07907575
- Testing
- ERBT and Adjuvant MMC Therapy, ERBT
- Where
- 2 sites in Hong Kong
- Volunteers
- 440 people
- Sponsor
- Chinese University of Hong Kong