Clinical trials: pills and oral medicines, open to volunteers
Allergy
Study of Oral Food Challenge Biomarkers (SAFER)
This is a multi-center, mechanistic study. It is designed to learn more about signs in the body, called biomarkers, that might show if someone will have a reaction to peanut during a feeding test.
- Trial name
- SAFER (NCT07279467)
- Testing
- Oral Food Challenge (OFC): Peanut Protein
- Where
- 10 sites in United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or Overweight
This is a randomized, placebo-controlled, double-blind, single and multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of ASC36 Tablets for Oral Use in Adult…
- Trial name
- NCT07893106
- Testing
- ASC36 tablets, for oral use
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Labour Dystocia
Oral Sodium Bicarbonate for the Prevention of Labour Dystocia
Sodium bicarbonate is often used by athletes to improve their muscle's ability to contract and power their activity. It works by decreasing the risk of lactic acid build-up, which causes cramping and fatigue.
- Trial name
- Labour-Aide (NCT06249061)
- Testing
- oral sodium bicarbonate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Liz Darling
Chemotherapy-induced Anemia, Non-Myeloid Malignancy
HEC53856 Tablets for Chemotherapy-induced Anemia in Non-myeloid Malignancies
A Phase II clinical trial to evaluate the efficacy and safety of different dosing regimens of HEC53856 tablets compared to rHuEPO injection in participants of the CIA trial.
- Trial name
- NCT07891377
- Testing
- HEC53856 tablet, rHuEPO injection
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Pouchitis
Rifaximin for the Secondary Prevention of Recurrent Pouchitis
Although many people will develop recurrent pouchitis (inflammation of the ileal pouch-anal anastomosis or J-pouch after colectomy for ulcerative colitis) after an initial episode of pouchitis, there are currently no effective…
- Trial name
- NCT06312683
- Testing
- Rifaximin 550 MG Oral Tablet [XIFAXAN]
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure
Qishen Yiqi Dripping Pills in Treatment of Chronic Heart FailUre
This trial will evaluate the efficacy and safety of Qishen Yiqi Dripping Pills in treatment of Chronic Heart Failure with reduced ejection fraction resorted from Coronary Heart Disease (Syndrome of Qi Deficiency with Blood…
- Trial name
- NCT07687186
- Testing
- Qishen Yiqi Dripping Pills 2 bags
- Where
- 60 sites in China
- Volunteers
- 636 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Rheumatologic Disease, Autoimmune Diseases
Testimonials and Navigation in Rheumatology
The overall goal of this study is to determine whether a novel, multi-modal, patient-directed behavioral intervention initiated in rheumatology clinics is an effective approach to improve uptake of updated COVID-19 vaccine.
- Trial name
- TANGO (NCT06469788)
- Testing
- Video comprised of AIRD patient narratives on COVID-19 vaccination thoughts and experiences, Video on the importance of good oral health for patients with AIRD, Brochure on COVID-19 vaccination in AIRD patients
- Where
- 4 sites in United States
- Volunteers
- 1,170 people
- Sponsor
- University of Alabama at Birmingham
Voiding Dysfunction, Substance Abuse
Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction
With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem.
- Trial name
- NCT03913819
- Testing
- First line treatment: oral NSAID and anticholinergic agents, Second line treatment: additional treatment for pain control, Third line treatment: A course of intravesical hyaluronate will be given.
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Edema Due to Heart Failure or Cirrhosis
A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric Patients
This is a 2-part, 2 periods per part, open-label study with spironolactone oral suspension in pediatric patients with edema due to HF or hepatic cirrhosis.
- Trial name
- NCT06021860
- Testing
- Spironolactone Oral Suspension
- Volunteers
- 96 people
- Sponsor
- CMP Development, LLC
Bacterial Vaginosis (BV)
WST03 Capsule Combined With Metronidazole for Bacterial Vaginosis
This is a multicenter, randomized, double-blind, placebo-controlled Phase 2 trial enrolling approximately 150 pre-menopausal women with bacterial vaginosis (BV). Participants will be randomized 1:1:1 to three groups.
- Trial name
- NCT07888699
- Testing
- High-dose WST03 Vaginal Capsule Metronidazole, Low-dose WST03 Vaginal Capsule Metronidazole
- Where
- 14 sites in China
- Volunteers
- 150 people
- Sponsor
- SPH Sine Pharmaceutical Laboratories Co., Ltd.
Breast Cancer, Peripheral Neuropathy Due to Chemotherapy
Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
This randomized, controlled, open-label trial will evaluate the efficacy and safety of amantadine, an NMDA receptor antagonist with antioxidant and anti-inflammatory properties, in preventing paclitaxel-induced peripheral…
- Conditions
- Breast Cancer, Peripheral Neuropathy Due to Chemotherapy, VAS Score
- Trial name
- NCT07889115
- Testing
- Amantadine (oral)
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Egg Allergy, Egg Hypersensitivity
Oral Immunotherapy for Children With Egg Allergy
This clinical trial aims to investigate if oral immunotherapy can help children with egg allergy tolerate eggs. Children aged 6-18 months can take part in the trial.
- Conditions
- Egg Allergy, Egg Hypersensitivity, Food Allergy in Children, Food Allergies
- Trial name
- NCT07888439
- Testing
- Oral immunotherapy with egg
- Where
- 5 sites in Denmark
- Volunteers
- 76 people
- Sponsor
- Laura Ozer Kettner
Lennox-Gastaut Syndrome
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS
This is a Phase 3b/Phase 4 study. The purpose of this study is to learn more about the efficacy of using CBD-OS as an add-on therapy for the treatment of LGS in adults.
- Trial name
- EpiGOAL (NCT07728097)
- Testing
- Cannabidiol Oral Solution
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Jazz Pharmaceuticals
Peanut Allergy
Efficacy of Tezepelumab in Peanut Oral Immunotherapy
The proposed study is a proof-of-concept Phase 2, double-blind, randomized placebo-controlled clinical trial evaluating the safety and efficacy of tezepelumab and peanut Oral Immunotherapy (OIT) for the treatment of peanut…
- Trial name
- ZENITH (NCT07015996)
- Testing
- Tezepelumab, Peanut Oral Immunotherapy (OIT)
- Where
- 10 sites in United States
- Volunteers
- 62 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Verapamil In Preclinical Type 1 Diabetes
Type 1 diabetes (T1D) is preceded by a presymptomatic phase featured by the presence of islet autoantibodies (aAbs) without (Stage 1) or with (Stage 2) dysglycemia.
- Trial name
- VIP-1 (NCT07880769)
- Testing
- Verapamil 120 Mg/24 Hours Oral Capsule, Extended Release, blood sampling, EKG and cardiological evaluation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Dental Caries, Dry Mouth
Oral Health Intervention in Adult Primary Care
This study is a Stage III cRCT to test the efficacy of multi-level interventions at the practice- and provider-level to address low dental utilization (attendance) among Medicaid-enrolled older adults 55 years or older attending…
- Conditions
- Dental Caries, Dry Mouth, Periodontal Diseases, Bleeding Gum
- Trial name
- NCT06555029
- Testing
- EHR Changes, Medical Staff EHR Training, Clinician CSM theory-based didactic education and skills training, Standard ADA Oral Health Training
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Treatment Resistant Depression, Treatment Resistant Depression (TRD)
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
Major depressive disorder (MDD) is a significant public health problem and leading cause of worldwide disability. Treatment resistance is common in MDD, however, for these individuals, targeted noninvasive brain stimulation is an…
- Trial name
- SPARC-TMS (NCT07227103)
- Testing
- Neuronavigated robotic-enabled TMS, NRX-101
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- NeuroRx, Inc.
Non-small Cell Lung Cancer
Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
This is a Phase 2b, multicenter, open-label study to evaluate the safety and efficacy of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC (Non-resistant Uncommon EGFR Mutations Only, Including L861Q, G719X…
- Trial name
- NCT05168566
- Testing
- Sutetinib Maleate Capsule
- Where
- 31 sites in United States, Australia and 1 more
- Volunteers
- 128 people
- Sponsor
- Teligene US