Clinical trials: pharmacological study, open to volunteers
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Lactation Disorders
The Relationship Between Oxytocin Massage in Mothers With Insufficient Milk Production in the Early Postpartum Period and Breastfeeding Self-Efficacy and Milk Let-down Reflex: A Randomized Controlled Study
This randomized controlled trial aims to evaluate the effects of oxytocin massage on breastfeeding self-efficacy and the milk ejection reflex among mothers experiencing insufficient milk supply in the early postpartum period.
- Trial name
- NCT07609693
- Testing
- Oxytocin Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Colorectal Cancer Metastatic
A Real-world Study of Chidamide in Combination with PD-1/PD-L1 Antibodies and Anti-angiogenic Agents in Advanced MSS Colorectal Cancer
This is an observational , multicenter, real-world study aimed at evaluating the efficacy and safety of the combination of immune checkpoint inhibitors, chidamide and antiangiogenic agents in Microsatellite Stable advanced…
- Trial name
- NCT06682247
- Testing
- Chidamide, Tucidinostat; PD-1/PD-L1 inhibitor or double antibodies; Bevacizumab or tyrosine kinase inhibitors
- Volunteers
- 200 people
- Sponsor
- Feng Wang
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Glaucoma
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique.
- Trial name
- NCT06993597
- Testing
- Prostaglandin Analogue -Containing IOP-Lowering Therapy, Beta Blocker, Brillouin Microscopy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Solid Tumors
Lenvatinib Plus PD-1 Inhibitor for Advanced Solid Tumors With 11q13 Amplification
The goal of this clinical trial is to learn if the combination of lenvatinib and a PD-1 inhibitor (a type of immunotherapy) works to treat advanced solid tumors that have a specific genetic change called "11q13 amplification".
- Trial name
- NCT07417501
- Testing
- Lenvatinib plus PD-1 Inhibitor
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Acute Coronary Syndrome
Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD
The goal of this observational study is to evaluate the implementation of a 'first-time-right' pharmacological treatment strategy in patients hospitalized with coronary artery disease.
- Trial name
- GOLDEN (NCT06637657)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 5,586 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Neonatal Opioid Withdrawal Syndrome, Prenatal Opioid Exposure
Recorded Parent/Caregiver Voice for Infants With Neonatal Opioid Withdrawal Syndrome
Neonatal opioid withdrawal syndrome (NOWS) can affect a newborn infant's ability to eat, sleep, and be consoled after exposure to opioids before birth.
- Conditions
- Neonatal Opioid Withdrawal Syndrome, Prenatal Opioid Exposure, Opioid Withdrawal, Neonatal Abstinence Syndrome
- Trial name
- VOICE-NAS (NCT07864493)
- Testing
- Recorded Parent/Caregiver Voice Playback
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Normal Vaginal Delivery, Perineal Episiotomy
Effect of Perineal Cryotherapy on Episiotomy
The present study aims to evaluate the effect of perineal cryotherapy on episiotomy- associated pain among postpartum women. The study hypothesis: Post-partum women who apply perineal cryotherapy have lower level of episiotomy…
- Trial name
- NCT06921200
- Testing
- Cryotherapy
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Solid Cancer, Gastric (Cardia, Body) Cancer
Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients
In this study, the drug capecitabine is investigated. Capecitabine is commonly used to treat breast, colon, and stomach cancers. Capecitabine is taken in tablet form.
- Conditions
- Solid Cancer, Gastric (Cardia, Body) Cancer, Esophageal Cancer, Colorectal Cancer (CRC)
- Trial name
- ESCAPE (NCT07114627)
- Testing
- Blood sampling for pharmacokinetics
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erasmus Medical Center
Anesthesia, Sedation
EEG Signal Correlates During Anesthesia and Sedation in Adults and Children
This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural…
- Conditions
- Anesthesia, Sedation, Consciousness Monitors
- Trial name
- SPECTRALADUPED (NCT07460414)
- Where
- 2 sites in France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HFpEF - Heart Failure With Preserved Ejection Fraction, Diabetic Cardiomyopathies
Tailored Exercise Training Study Among Adults With HFpEF
Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF.
- Trial name
- TEXPEF (NCT07223242)
- Testing
- Moderate-intensity continuous training (MCT), Resistance training, Weight loss
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Recurrent or Metastatic Head and Neck Carcinoma
Sacituzumab Tirumotecan Plus Immunotherapy for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This is a single-center, open-label phase 2 study evaluating sacituzumab tirumotecan in combination with an immune checkpoint inhibitor in patients with previously treated recurrent or metastatic head and neck squamous cell…
- Trial name
- NCT07686588
- Testing
- Sacituzumab Tirumotecan Plus Immune Checkpoint Inhibitor
- Volunteers
- 20 people
- Sponsor
- Biying Chen
Lymphedema
Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which…
- Trial name
- NCT07012642
- Testing
- GLP-1 Receptor Agonists
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Obesity and Overweight
Impact of Bariatric Surgery and Liraglutide on Cognitive-Behavioral Markers of Long-Term Weight Loss in Obesity
The present research project aims to study the effects of bariatric surgery and liraglutide administration (in patients already selected for one of these procedures) on two cognitive-behavioral processes partially supported by…
- Trial name
- Balance (NCT06720246)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Recurrent Thyroid Cancer
Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
The goal of this study is to evaluate combined radioactive iodine (RAI, 131-I) and external beam radiotherapy (XRT) to optimize the radiation dose delivered to treat well differentiated thyroid cancers (DTC) with iodine-avid…
- Trial name
- NCT04892303
- Testing
- Combination treatment (CXRPT) of external beam radiation (XRT) plus radioactive iodine (RAI)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Abscess
A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast Abscesses
The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous breast abscess drainage for disinfection of breast abscesses.
- Trial name
- NCT07179003
- Testing
- Standard of care breast abscess drainage, Methylene Blue, Lipid Emulsion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Substance Abuse Disorder, Dialectical Behavior Therapy
Implementing DBT in Short-Term SUD-treatment
The main objective of the study is to provide new knowledge about the implementation of DBT-informed environmental therapy in short-term substance use disorder (SUD) inpatient treatment.
- Conditions
- Substance Abuse Disorder, Dialectical Behavior Therapy, Emotion Management Skills
- Trial name
- NCT07693439
- Testing
- DBT-informed milieu therapy, Treatment as usual
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Helse Møre og Romsdal HF
Fibromyalgia, Fibromyalgia (FM)
Multisite Transcutaneous Electrical Nerve Stimulation in Fibromyalgia: A Randomized, Double-Blind, Sham-Controlled Crossover Trial Comparing Two Stimulation Modalities
Fibromyalgia is a chronic and multifactorial disorder characterized by widespread musculoskeletal pain, heightened pain sensitivity, fatigue, sleep disturbances, cognitive complaints, and affective symptoms such as anxiety and…
- Conditions
- Fibromyalgia, Fibromyalgia (FM), Fibromyalgia (FM) OR Fibromyalgia Syndrome
- Trial name
- FIBROPULSE (NCT07872631)
- Testing
- EXOPULSE Mollii Suit
- Volunteers
- 24 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences