Clinical trials: injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Cervical Intraepithelial Neoplasia
Impact on Disease Relapse of HPV Vaccination in Women Treated With LEEP for Cervical Intraepithelial Neoplasia. HOPE9
This study evaluates the impact on disease relapse of presurgical 9-valent HPV vaccination versus placebo vaccination in women treated with LEEP (loop electrosurgical excision procedure) for CIN2+ (high grade cervical…
- Trial name
- HOPE9 (NCT03848039)
- Testing
- Gardasil-9
- Volunteers
- 1,220 people
- Sponsor
- Alessandro Ghelardi
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignancies
A Study of CD19/BCMA-targeted CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Acute Lymphoblastic Leukemia, B-cell Non-Hodgkin's Lymphoma and Multiple Myeloma.
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphocytic Leukaemia Refractory
- Trial name
- NCT04603872
- Testing
- CD19/BCMA Targeted CAR T-cells and dasatinib, CD19/BCMA Targeted CAR T-cells
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang University
Acute Myeloid Leukemia
IL3 CAR-T Cell Therapy for Patients With CD123 Positive Relapsed and/or Refractory Acute Myeloid Leukemia
A Study of IL3 CAR-T Cell Therapy for Patients With CD123 Positive Relapsed and/or Refractory Acute Myeloid Leukemia.
- Trial name
- NCT04599543
- Testing
- IL3 CAR T-cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Zhejiang University
Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma
A Study of CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Central Nervous System Hematological Malignancies
A Study of CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Central Nervous System Hematological Malignancies
- Trial name
- NCT04532203
- Testing
- CAR-T cells, Ommaya Reservoir
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Zhejiang University
Acute Lymphoblastic Leukemia, Non-Hodgkin Lymphoma of Soft Tissue
A Study of Murine CD19 CAR-T Therapy for Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancies
A Study of Murine CD19 CAR-T Cells Therapy for Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancies.
- Trial name
- NCT04532281
- Testing
- Murine CD19 CAR-T cells
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang University
Relapsed and Refractory, Lymphoid Hematological Malignancies
A Study of CD20/CD22 Targeted CAR T-cell Therapy for Relapsed or Refractory Lymphoid Malignancies
A Study of CD20/CD22 Targeted CAR T-cell Therapy for Relapsed or Refractory Lymphoid Malignancies.
- Trial name
- NCT04283006
- Testing
- CD20/CD22 dual Targeted CAR T-cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- He Huang
Psoriasis
ILUMYA in Combination With HALOG Ointment 0.1% for Plaque Psoriasis.
Patient with moderate-to-severe plaque psoriasis will receive Ilumya with or without Halog ointment.
- Trial name
- NCT04347473
- Testing
- Ilumya Injectable Product
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Psoriasis Treatment Center of Central New Jersey
Mammary Cancer
Omission of Surgery and Sentinel Lymph Node Dissection in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti- HER2-based Neoadjuvant Therapy (ELPIS Trial)
This is a prospective, single arm, open-label, exploratory study in women with primary operable HER2-positive, HER2-enriched(HER2-E)/ERBB2-high breast cancer according to PAM50 intrinsic subtype and a ERBB2 pre-defined cutoff…
- Trial name
- ELPIS (NCT04301375)
- Testing
- Pertuzumab and trastuzumab FDC subcutaneous, Paclitaxel, TDM1
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- David Garcia Cinca
Orthopedic Disorder, Neurologic Disorder
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions.
- Conditions
- Orthopedic Disorder, Neurologic Disorder, Urologic Diseases, Erectile Dysfunction
- Trial name
- NCT03899298
- Testing
- Amniotic and Umbilical Cord Tissue Procedure
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell
Ulcerative Colitis, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Ulcerative Colitis
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome.
- Trial name
- NCT03804931
- Testing
- Fecal microbiota transplantation, Infusion of Saline, 5-Aminosalicylic acid(5-ASA) and/or Prednisone
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangzhou First People's Hospital
Heart Failure
Utility of Some Novel Biomarkers of Patients With Chronic Heart Failure
Clinical and Economic study of some new biomarkers in chronic heart failure.
- Trial name
- NCT03772275
- Testing
- New york Heart Association Class II-IV, New york Heart Association Class I
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sherief Abd-Elsalam
Type 1 Diabetes Mellitus
Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patients
The transition from the Pediatric clinic to the adult care is a challenging period for young adults with type 1 diabetes, due to the high risk of poor glycemic control.
- Trial name
- METRO (NCT03463564)
- Testing
- Insulin pump, Insulin injections
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Chemotherapy, Adjuvant, Lung Adenocarcinoma, Stage I
Surgery With or Without Chemotherapy for Stage I NSCLC With Micropapillary Component ≥ 20%
Randomized phase II trial aims to compare surgery with or without adjuvant chemotherapy in treating patients who are pathologically diagnosed as stage I lung adenocarcinoma with micropapillary component no less than 20%.
- Conditions
- Chemotherapy, Adjuvant, Lung Adenocarcinoma, Stage I, Treatment, Histological Type of Neoplasm
- Trial name
- NCT03351842
- Testing
- cis Platinum/Carboplatin, Pemetrexed Disodium, Undergo surgery
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Tendon Injury - Hand
Wide-Awake Local Anesthesia vs. Regional/General Anesthesia for Flexor Tendon Repair
Wide-awake hand surgery with local anesthetic, no tourniquet and no sedation (WALANT) is increasingly utilized. Conventional anesthesia for hand surgery involves a patient with a block, unable to perform motor function in the…
- Trial name
- NCT03135340
- Testing
- WALANT, General/regional anesthesia, WALANT Injection
- Volunteers
- 88 people
- Sponsor
- University of Western Ontario, Canada
Post-ERCP Acute Pancreatitis
Lactated Ringer's Solution to Prevent Post-ERCP Pancreatitis
This is a randomized, double-blinded, controlled trial. This study is a head to head comparison of normal saline (NS) infusion versus Lactated Ringer's (LR) infusion in patients, with the primary outcome of post-ERCP pancreatitis…
- Trial name
- NCT03215862
- Testing
- Lactated Ringer, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 242 people
- Sponsor
- University of South Florida