Clinical trials: conventional surgery
Fibrinogens, Abnormal
Kinetics of Plasma Fibrinogen in Cardiac Surgery
The study intends to measure fibrinogen plasma levels during the first 24 hrs in cardiac and thoracic surgical patients who undergo surgical procedures using extracorporeal circulation.
- Trial name
- NCT02605330
- Testing
- Fibrinogen plasma level
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hepatolithiasis, Hepatectomy
Application of Three- Dimensional Visualization Combined With ICG Molecular Fluorescence Imaging in Hepatolithiasis
This study adopted a retrospective study method to explore the clinical application value of 3D visualization combined with ICG molecular fluorescence imaging technology in hepatolithiasis, and further analyze whether 3D…
- Trial name
- NCT06447181
- Testing
- 3D visualization technology ; ICG fluorescence technology .
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Mandibular Angle Fracture
Evaluation of Patient-specific Surgical Stents and Plates for Guided Reduction And Fixation of Mandibular Angle Fractures
This study will evaluate the patient specific surgical stent and plate for guided reduction and fixation of mandibular angle fractures.
- Trial name
- NCT07375030
- Testing
- Patient specific surgical stents and plates for guided reduction and fixation of mandibular angle fixation, fracture reduction performed using conventional intraoperative manual techniques without a reduction guide.
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Alexandria University
Open-angle Glaucoma
Efficacy and Safety of XEN® Gel Stent and Post-operative Management in Patients With Open Angle Glaucoma
To evaluate the efficacy of postoperative management with 5-fluorouracil injections after XEN Gel Stent implantation.
- Trial name
- NCT03904381
- Testing
- 5-fluorouracil, Transconjunctival needling, Transconjunctival revision
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Wroclaw Medical University
Leukemia, Lymphoma
Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003728
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 23 sites in Belgium, France and 1 more
- Volunteers
- 1,500 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Sarcoma
Combination Chemotherapy in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002492
- Testing
- cisplatin, doxorubicin hydrochloride, isolated limb perfusion
- Where
- United States
- Sponsor
- University of Miami
Knee Replacement, Total Knee Arthroplasty
Trial of Liposomal Bupivacaine for TKA
Total knee arthroplasty (TKA), also known as a knee replacement, is a procedure performed to reduce severe pain and improve function of the joint.
- Conditions
- Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
- Trial name
- NCT05635916
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northern Light Mercy Hospital
Complication of Surgical and Medical Care.
Enhanced Recovery After Surgery in Major Intrabdominal Procedures.
Enhanced Recovery After Surgery (ERAS) programs have been introduced with aims of attenuating the stress response to surgery and enabling rapid recovery.
- Trial name
- NCT01400711
- Testing
- ERAS perioperative care, Traditional
- Where
- Greece
- Volunteers
- 54 people
- Sponsor
- St. Andrew's General Hospital, Patras, Greece
Joint Disease, Arthropathy
A Study Investigating the Efficacy of Various Wound Closure Devices in Reducing Postoperative Wound Complications
A single-center, phase IV, randomized, prospective study investigating the efficacy of various wound closure devices in reducing postoperative wound complications.
- Trial name
- NCT03134209
- Testing
- Zipper surgical skin closure, Monocryl + Dermabond, Polyester mesh + Dermabond
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- NYU Langone Health
Bladder Cancer
Investigation Into the Integration of Intracavitary Cryoablation and Immunotherapy in Bladder-Preserving Therapy
Professional Translation: This study is a single-center, prospective, non-randomized, parallel-controlled clinical trial initiated and conducted by the Department of Urology at the First Affiliated Hospital of Naval Medical…
- Trial name
- NCT07204132
- Testing
- TURBT combined with cryoablation-assisted postoperative immunotherapy, The conventional surgery treatment group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Changhai Hospital
Dry Eye Syndrome
Efficacy of Warm Compress Therapy in Enhancing Tear Film Quality and Reducing Postoperative DES
Dry eye disease (DED) is a multifactorial condition often exacerbated by cataract surgery, leading to discomfort and visual disturbances.
- Trial name
- NCT06914232
- Testing
- Warm Compress, Standard Care
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Superior University
Bladder Cancer
Chemotherapy With or Without Surgery in Treating Patients With Bladder Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Infusing chemotherapy drugs directly into the bladder may kill more cancer cells.
- Trial name
- NCT00042887
- Testing
- mitomycin C, conventional surgery
- Where
- 12 sites in Belgium, Italy and 3 more
- Volunteers
- 58 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Esophageal Cancer, Oesophageal Cancer
PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer
This is a prospective, randomized, open-label, two-arm phase 2 trial that will evaluate whether the use of Pulsed Low-Dose-Rate radiation technique, as compared to standard radiation, is associated with reduced rates of…
- Conditions
- Esophageal Cancer, Oesophageal Cancer, GastroEsophageal Cancer
- Trial name
- NCT06906887
- Testing
- Induction Chemotherapy (modified FLOT or modified FOLFOX-6), Chemotherapy, Conventional Radiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Wound Infection
Compare Antimicrobial to Conventional Suture in Patients Receiving Primary Total Knee Replacement
Total knee replacement is now one of the most popular reconstructive procedures for the elderly people to regain their functional capacity and life quality.
- Trial name
- Vicryl-Plus (NCT02533492)
- Testing
- vicryl, Vicryl plus
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Mel Shiuann-Sheng Lee
Extrahepatic Bile Duct Cancer, Liver Cancer
Radiation Therapy and Fluorouracil Before Surgery in Treating Patients With Primary or Recurrent Bile Duct Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00030511
- Testing
- fluorouracil, conventional surgery, radiation therapy
- Where
- 6 sites in United States, Belgium and 1 more
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cardiac Toxicity, Sarcoma
Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00019864
- Testing
- filgrastim, cisplatin, dexrazoxane hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma
Enhanced Recovery After Surgery in Extremity Sarcoma
The purpose of this study is to demonstrate the efficacy of implementing the enhanced recovery after surgery (ERAS) pathway in a prospective manner to patients undergoing surgical treatment for extremity sarcoma.
- Trial name
- NCT04461171
- Testing
- Enhanced Recovery After Surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Joshua Lawrenz
Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery
A Randomized Study of Gas Bubble Technique in Cataract Surgery
To investigate the efficiency and safety of using "Gas Bubble Technique" to reduce corneal endothelial damage in hard nucleus cataract patients.
- Trial name
- NCT06636279
- Testing
- Gas bubble technique
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan Provincial People's Hospital
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced Esoph and Gastro-esoph Jction CA
ARTemIS-Eso is a phase I-II, three-level, open-label trial with a dose-expansion cohort at recommended schedule in both esophageal cancer histological groups (squamous cell carcinoma and adenocarcinoma) of RCT and ImT…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Squamous Cell Carcinoma of the Esophagus
- Trial name
- ARTEMIS-Eso (NCT03307941)
- Testing
- Monalizumab, Oxaliplatin, 5-Fluorouracil
- Where
- Belgium
- Sponsor
- Jules Bordet Institute