Clinical trials: Vancomycin
Antibiotic Prophylaxis, General Surgery
Linezolid or Vancomycin Surgical Site Infection Prophylaxis
Anesthesia and surgical guidelines recommend the administration of a surgical antibiotic prophylaxis for patients undergoing "clean" surgery.
- Trial name
- LOVip (NCT05571722)
- Testing
- Vancomycin Injection, Linezolid Injection
- Where
- France
- Volunteers
- 1,160 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prosthetic-joint Infection
Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty
The objective of the protocol is to provide access to the VT-X7 (Vancomycin, Tobramycin Exchanged in 7 Days) system for subjects with periprosthetic joint infection (PJI) of the hip or knee who lack therapeutic treatment…
- Trial name
- APEX-EAP (NCT06383611)
- Testing
- VT-X7 Treatment System
- Where
- 14 sites in United States
- Sponsor
- Osteal Therapeutics, Inc.
Prosthetic Joint Infection
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Total joint replacement is a common clinical practice for patients suffering from disabling arthritis, since it provides significant pain relief and functional recovering.
- Trial name
- NCT02413034
- Testing
- Cefazolin, Control group
- Volunteers
- 28 people
- Sponsor
- Parc de Salut Mar
Endophthalmitis
Endophthalmitis Post Intravitreal Injections
Intravitreal injection (IVI) is an ophthalmological procedure used worldwide to treat ocular conditions. Its use has been steadily increasing for several years, because this method of drug delivery minimizes systemic exposure and…
- Trial name
- EPIIC (NCT04035369)
- Testing
- Tap and Inject (TAI), Pars Plana Vitrectomy (PPV)
- Where
- Canada
- Volunteers
- 310 people
- Sponsor
- Unity Health Toronto
Clostridium Difficile Infection Recurrence
Bezlotoxumab (BEZLO) In Addition To Standard Of Care (SOC) Vancomycin For The Treatment of Multi-Recurrent Clostridium Difficile Infection
This is a research study to collect information from people that have Clostridium difficile infection (CDI) and are treated with a standard antibiotic treatment in which the antibiotic dose is gradually reduced over 6 weeks and…
- Trial name
- BEZLO (NCT03880539)
- Testing
- bezlotoxumab, Vancomycin Oral
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Kansas Medical Center
Bone or Joint Infection
Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus
This is a randomized, active-controlled, open-label study to assess the safety, tolerability and efficacy of Afabicin in the treatment of participants with bone or joint infection due to Staphylococcus aureus [both…
- Trial name
- NCT03723551
- Testing
- Afabicin, Cefazolin, Vancomycin
- Where
- 19 sites in Georgia, South Africa and 1 more
- Volunteers
- 67 people
- Sponsor
- Debiopharm International SA
VRE Colonization, CRE Colonization
Human Clinical Trial to Evaluate the Decolonization Efficacy of BM111 Against Carbapenem-Resistant Enterobacteriaceae (CRE) and Vancomycin-Resistant Enterococcus (VRE)
A clinical study to eliminate intestinal colonization in subjects harboring microorganisms resistant to carbapenem and vancomycin antibiotics, thereby treating infections caused by these microorganisms.
- Trial name
- NCT07525089
- Testing
- BM111
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- BioMe Inc.
Coronary Artery Disease
Effect of Probiotic Supplementation on Endothelial Function
The study is being performed to determine whether probiotics (GoodBelly) improves blood vessel function.Probiotics similar to yogurt are living micro-organisms (beneficial to its host) the lives in the intestine.
- Trial name
- NCT01952834
- Testing
- GoodBelly Probiotic, Vancomycin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical College of Wisconsin
Fever, Febrile Neutropenia
Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia
Neutropenic fever is a life threatening condition that is not rare in patients suffering from hematologic disorders, and of paramount importance to early and effective treatment.
- Trial name
- RR (NCT02463747)
- Testing
- Piperacillin/tazobactam, Ceftazidim, Meropenem
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Vancomycin Resistance Enterococcus Faecium
Zyvox (Linezolid) Special Investigation For Vancomycin-Resistant Enterococci (VRE)
To collect the efficacy and safety information in subjects who have been treated with Zyvox (linezolid) for vancomycin resistance Enterococcus faecium infection for their appropriate use in daily practice.
- Trial name
- NCT01224626
- Testing
- Zyvox (linezolid)
- Volunteers
- 41 people
- Sponsor
- Pfizer
Blood Stream Infections, Endocarditis
Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin
1. Drug resistance of G+ cocci is a severe healthcare problem. According to the Ministry of Health National Antimicrobial Resistant Investigation Net (mohnarin) surveillance report, the isolation rate of MRSA is some 60% in…
- Conditions
- Blood Stream Infections, Endocarditis, MRSA
- Trial name
- NCT02443064
- Testing
- Vancomycin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang University
Acute Kidney Injury
Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty
A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients.
- Trial name
- NCT03921099
- Testing
- Ascorbic Acid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Rhegmatogenous Retinal Detachment
Dropless Pars Plana Vitrectomy Study
To demonstrate that intraoperative use of subtenon triamcinolone acetonide at the time of surgery without postoperative eye drops is non-inferior to the regimen of postoperative eye drops following primary pars plana vitrectomy…
- Trial name
- DVS (NCT05331664)
- Testing
- Pars plana vitrectomy, Triamcinolone Acetonide 40mg/mL, Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence
Secondary Prevention of Clostridioides Difficile Using Vancomycin
Re-exposure to systemic antibiotics (i.e., antibiotics absorbed into the bloodstream) is common after a Clostridioides difficile infection (CDI) and is the strongest risk factor for a recurrent episode.
- Conditions
- Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Clostridoides Difficile Associated Disease
- Trial name
- SPORES-V (NCT06979609)
- Testing
- Oral Vancomycin Prophylaxis
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Lumbar Fusion Surgery
IO Vancomycin Spine
The goal of this research is to learn if injecting the antibiotic vancomycin directly into the bone marrow (intraosseous) or IO) during a lumbar (spinal) fusion surgery, is as effective or better than the standard method of…
- Trial name
- NCT06748144
- Testing
- Intraosseous Vancomycin, Intravenous Vancomycin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Clostridium Difficile Infection
Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile
This study proposes to: 1. Characterize the impact of oral vancomycin on C. difficile loads after end of treatment compared to a placebo group. 2.
- Trial name
- NCT03827447
- Testing
- Vancomycin Oral Capsule
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Medical College of Wisconsin
Prosthesis-related Infections, Staphylococcal Infections
Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty
The number of patients requiring joint replacement is increasing due to its success in restoring function and pain relief, and the growing population of the elderly.
- Trial name
- NCT00423982
- Testing
- Rifampin-combination therapy, Monotherapy
- Where
- 8 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Antimicrobial Resistance, Colonization
Fecal Microbiota Transplantation for CRE/VRE
Multidrug-resistant organisms (MDRO) present an increasingly serious public health threat to the global community.The prevalence of various MDRO, including carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant…
- Trial name
- NCT03479710
- Testing
- FMT infusion
- Where
- Hong Kong
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
MRSA
Vancomycin Monitoring: Is AUC Monitoring Appropriate for More Than Just Serious MRSA Infections?
Vancomycin, a glycopeptide antibiotic, is commonly prescribed as initial therapy for hospitalized patients due to its broad gram-positive coverage.
- Trial name
- NCT05395520
- Testing
- Retrospective chart review
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Methodist Health System
Clostridium Difficile Infection
Oral Vancomycin for Preventing Clostridium Difficile Recurrence
This study evaluates the role of oral vancomycin in the prevention of recurrent Clostridium difficile for hospitalized patients receiving systemic antibiotic therapy.
- Trial name
- NCT03200093
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rochester General Hospital