Clinical trials: Tranexamic Acid
Blood Loss
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty
This research study aims to study the use of tranexamic acid (TXA) in total joint replacement (arthroplasty) of the hip (THR) and knee (TKR).
- Trial name
- NCT03825939
- Testing
- Intravenous Tranexamic Acid
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Blood Loss, Blood Transfusion
Oral Versus Intravenous Tranexamic Acid
The goal of this randomized clinical control trial is to determine whether oral TXA dosing in THA/TKA result in more blood loss and more transfusions compared to IV TXA dosing in patients undergoing THA/TKA under neuraxial…
- Trial name
- NCT04089865
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Epistaxis
Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department
It is estimated that epistaxis results in 4.5 million emergency department visits per year throughout the United States. Due to the adverse effects of standard treatment options for epistaxis, tranexamic acid (TXA) may be…
- Trial name
- NCT02930941
- Testing
- Tranexamic Acid, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Davis
Arteriovenous Fistula
Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients
This study will investigate how the use of Tranexamic acid and Bacitracin applied to the bleeding site after the hemodialysis fistula needle is removed will affect Time to Clot and Infection Rate
- Trial name
- NCT02106962
- Testing
- Topical Tranexamic Acid 5% with bacitracin, Topical Tranexamic Acid 25% with bacitracin
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- California Institute of Renal Research
Ovarian Cancer
Tranexamic Acid in Surgery of Advanced Ovarian Cancer
The purpose of the study is to determine if a standardized single dose tranexamic acid given intravenously immediately preoperatively reduces the perioperative bleeding volume and reduces the need of blood transfusion in women…
- Trial name
- NCT00740116
- Testing
- Tranexamic acid, 0.9% NaCl solution
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Preben Kjolhede, MD, professor
Pediatric Cancer, Thrombocytopenia
A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia
This study evaluates the use of tranexamic acid (TXA) in addition to standard therapy in children receiving chemotherapy or blood and/or marrow transplantation to decrease the risk of bleeding.
- Conditions
- Pediatric Cancer, Thrombocytopenia, Hemostatic Disorder, Coagulation Defect; Acquired
- Trial name
- NCT03806556
- Testing
- Tranexamic Acid, Normal saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Meghan McCormick
Postpartum Hemorrhage
Prevention of Postpartum Hemorrhage With Tranexamic Acid
Postpartum hemorrhage is a significant contributor to maternal morbidity and mortality and is worldwide. TXA has recently been proven to reduce mortality when given to women in setting of diagnosed PPH.
- Trial name
- NCT03287336
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- George Washington University
Bleeding
Efficacy of Tranexamic Acid and Epsilon-aminocaproic Acid in Reducing Bleeding and Transfusions in Cardiac Surgery
The investigators primary objective is to compare the effectiveness of epsilon-aminocaproic acid (EACA) and tranexamic acid (TA) in reducing bleeding and transfusion in cardiac surgery, with the hypothesis that TA is more…
- Trial name
- NCT02655653
- Testing
- Epsilon-aminocaproic acid administered, Tranexamic Acid administered
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Subdural Hematoma
A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population
This is a single center single arm study of 50 patients to 1) determine the safety of tranexamic acid in the chronic subdural hematoma population following surgical drainage of chronic subdural hematomas and 2) determine if the…
- Trial name
- TXA in CSDH (NCT02618382)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Hip Fractures
Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population
The overall design of the study is a prospective, double-blinded, randomized study in the geriatric hip fracture population comparing those who receive intravenous tranexamic acid prior to incision to those who receive a placebo.
- Trial name
- TAHFT (NCT03923959)
- Testing
- Tranexamic Acid Injectable Solution
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Lancaster General Hospital
Tibial Tubercle Osteotomy
Reducing Hemarthrosis in Tibial Tubercle Osteotomy by the Administration of Intravenous Tranexamic Acid
The purpose of the proposed study is to evaluate the effects of administering intravenous tranexamic acid (TXA) to patients undergoing high tibial osteotomy (HTO) and tibial tubercle osteotomy (TTO) to minimize hemarthrosis…
- Trial name
- NCT03606109
- Testing
- Tranexamic Acid (TXA)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- NYU Langone Health
Total Joint Arthroplasty
Reinfusion Drains vs Tranexamic Acid in Total Joint Arthroplasty
It is widely reported that a large percentage of total joint replacement patients receive allogeneic (human donor blood) blood transfusions due to perioperative blood loss with numbers ranging from 30% to 80%.
- Trial name
- NCT01636414
- Testing
- Hemovac drain, Re-infusion drain, Tranexamic drain
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Tranexamic Acid Dosing for Major Joint Replacement Surgery
Over 1.7 million hip and knee replacements are performed every year worldwide. These surgeries are associated with high blood loss and transfusion rates. In older patients, the high blood loss can result in postoperative anemia.
- Trial name
- TXA-Dosing (NCT05075200)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Sunnybrook Health Sciences Centre