Clinical trials: Propofol
Dysphagia, Respiratory Complications
Trial- Dysphagia From ETT or GI Endoscopy
The purpose of this study is to conduct a randomized clinical trial to compare the incidence of dysphagia in patients receiving general anesthesia with and without an endotracheal tube for Upper gastrointestinal endoscopy.
- Trial name
- NCT02460055
- Testing
- endotracheal tube, propofol, Fentanyl
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Anaesthesia
General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.
The purpose of this study is to evaluate the quantity of propofol administered with Xenon in two inspiratory concentrations, to maintain comparable depth of anaesthesia during the maintenance period of general anaesthesia.
- Trial name
- NCT00919126
- Testing
- Xenon, Medical Air in Oxygen
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 102 people
- Sponsor
- Air Liquide SA
Patients Undergoing Rigid Bronchoscopy
A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor
Standard ASA fasting guidelines will be followed. IV 20 gauge cannula will be inserted and dedicated to the infusion drugs. Standard ASA monitors will be attached, and baseline heart rate (HR), mean arterial blood pressure (MAP)…
- Trial name
- NCT07409935
- Testing
- Propofol saline, Propofol Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Conscious Sedation
Closed-loop Sedation of Propofol for Patients Undergoing Spinal Anesthesia
The purpose of this study is to compare the administration of a standard anesthetic drug (propofol) using an automatic, expert-based system versus a manually controlled system by the anesthesiologist.
- Trial name
- NCT01020643
- Testing
- controlled administration of propofol
- Where
- Canada
- Volunteers
- 203 people
- Sponsor
- Thomas Hemmerling
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland
Nociceptive Pain, Sedation Complication
Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care Unit
Due to their underlying pathology and the necessary complicated procedures to which they are exposed, patients in the intensive care unit experience varying degrees of pain at some point in their evolution.
- Trial name
- NCT05399758
- Testing
- NOL monitor
- Where
- 2 sites in Chile
- Sponsor
- University of Chile
Esophageal Cancer
Total Intravenous Anesthesia and Recurrence Free Survival
The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or…
- Trial name
- NCT04513808
- Testing
- Propofol-based total intravenous anesthesia, Sevoflurane intravenous anesthesia
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- The Cleveland Clinic
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- ISO-DRIVE (NCT06014138)
- Testing
- Propofol, Isoflurane
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Liver Disease
Propofol and Remifentanyl Versus Midazolam and Fentanyl for Diagnostic Colonoscopy in Patients With Compensated Cirrhosis Child A-B
This is a prospective, randomized-controlled trial (RCT) comparing the use of Propofol and Remifentanyl and traditional sedation (Midazolam and Fentanyl) for diagnostic colonoscopies in patients with compensated cirrhosis child…
- Trial name
- NCT01148277
- Testing
- Propofol and Remifentnyl, midazolam and fentanyl, midazolam anf fentanyl
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Ziv Hospital
Propofol Injection Pain in Children
Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children
Propofol is a drug commonly used for induction of general anesthesia in children as well as adults; however, propofol can cause pain on injection, possibly more frequently in children.
- Trial name
- NCT07770581
- Testing
- Buzzy device, Intravenous lidocaine
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anesthetics
A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values
The aim of this study is to determine whether induction of anesthesia with thiopental followed by propofol infusion is able to maintain sufficient depth of anesthesia .
- Trial name
- NCT01140100
- Testing
- propofol, thiopental,propofol
- Where
- Iran
- Volunteers
- 82 people
- Sponsor
- Shiraz University of Medical Sciences
Electroencephalography
EEG Characteristics of Different Sedation Depths in Neurosurgery Patients
Gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments…
- Trial name
- NCT04365777
- Testing
- OAA/S=5, OAA/S=3, OAA/S=1
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- Beijing Tiantan Hospital
Intubation; Difficult or Failed, Obesity
The Role of Anthropometric Measurements and Ultrasonograpic Suprasternal Adipose Tissue Thickness
Prediction of difficult preoperative intubation in obese patients and completion of preparations for difficult intubation both reduce the risk of repeated intubation and prevent complications.
- Conditions
- Intubation; Difficult or Failed, Obesity, Anesthesia
- Trial name
- NCT06457165
- Testing
- Difficult Intubation, Not Difficult Intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries
Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries
Sinus surgery is one of the most prevalent ear, nose, and throat (ENT) surgeries, which is mainly carried out nowadays through functional endoscopic sinus surgery (FESS) and leads to significant improvement in the clinical…
- Conditions
- Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries, Hypotension
- Trial name
- NCT07585201
- Testing
- controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Anesthesia, General
Automated Anesthesia During Bronchoscopy
The purpose of this study is to compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during rigid bronchoscopy.
- Trial name
- NCT00571181
- Testing
- Closed-loop system, TCI (Infusion Toolbox)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Hopital Foch
Cognition
Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy
To investigate the effect on cognition under sedation by Rimazole toluenesulfonatein elderly patients undergoing colonoscopy
- Trial name
- NCT05255211
- Testing
- Remimazolam tosilate, Propofol, saline solution
- Where
- China
- Volunteers
- 90 people
- Sponsor
- RenJi Hospital
Tracheal Intubation Morbidity, Pain
Prediction of Hemodynamic Response to Intubation by ANI Variation During Standardized Stimulation
The objective : to investigate a correlation between ANI following a standardized nociceptive stimulus and hemodynamic or somatic reactions during orotracheal intubation. Piloted study.
- Trial name
- ANI_LARYNGO (NCT04354311)
- Testing
- ANI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Sedation
Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia
Controversies exist about the use of propofol in sedation of patients for cataract surgery. This prospective randomised double-blind study evaluates the efficacy of patient-controlled sedation compared with placebo using the same…
- Trial name
- CATARSIS (NCT02771912)
- Testing
- Propofol
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Inguinal Hernia
Awake Caudal Catheter vs General Anesthesia
It is well established that preterm inguinal hernias discovered in the NICU pose a significant surgical risk due to the associated co-morbid conditions that accompany these patients.
- Trial name
- NCT05919732
- Testing
- Bupivacaine, Dexmedetomidine, Caffeine, Tylenol, Propofol, rocuronium, caffeine, Tylenol, bupivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Status Epilepticus
Ketamine in Refractory Convulsive Status Epilepticus
To evaluate the efficacy of intravenous administration of ketamine in the treatment of refractory convulsive status epilepticus in children compared to administration of midazolam at high doses, thiopental and / or propofol.
- Trial name
- KETASER01 (NCT02431663)
- Testing
- Ketamine
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Meyer Children's Hospital IRCCS