Clinical trials: Propofol
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Oocyte Retrieval for IVF
Virtual Reality Hypnosis as Sedation During Oocyte Retrieval: Effect on Propofol Consumption
An egg retrieval is performed during an IVF course. This painful procedure is performed using sedation to ensure patient comfort.
- Trial name
- VRH-IVF (NCT07104409)
- Testing
- virtual reality hypnosis device
- Volunteers
- 72 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Delirium on Emergence
Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
Children who receive general anesthesia may become agitated (emergence delirium) in the recovery period. This occurs more often after inhalational anesthetics, particularly sevoflurane and desflurane than after propofol.
- Trial name
- NCT02111447
- Testing
- Propofol, Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York at Buffalo
Delirium in Old Age
How Different Sedatives Affect Hip Fracture Patient's Postoperative Delirium
the hypothesis is that Dexmedetomidine seems to decrease incidence of post-operative delirium . one possible mechanism is that Dex have a minor influence on cognition, since it has no effect on GABA receptor，another is that Dex…
- Trial name
- NCT03346226
- Testing
- Dexmedetomidine Hydrochloride, Propofol
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Remimazolam, Desflurane
Remimazolam vs Propofol as an Induction Agent for Morbid Obesity Patients
It is known that morbidly obese patients are often accompanied by cardiovascular complications such as hypertension, cardiac hypertrophy, and diastolic dysfunction, and are known to increase the risk of hypotension during…
- Conditions
- Remimazolam, Desflurane, Morbid Obesity, Sleeve Gastrectomy
- Trial name
- NCT05856617
- Testing
- Remimazolam besylate
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Seoul National University Bundang Hospital
Dexmedetomidine Induced Sedation, Nasal Administration
Efficacy Study of Dexmedetomidine Nasal Spray Combined With Propofol for Deep Sedation in ERCP
This prospective randomized single-blind study evaluated the safety and efficacy of combining dexmedetomidine nasal spray with propofol for ERCP (Endoscopic Retrograde Cholangiopancreatography) sedation in eligible patients aged…
- Conditions
- Dexmedetomidine Induced Sedation, Nasal Administration, Sprays
- Trial name
- NCT07204106
- Testing
- Dexmedetomidine Injection (nasal spray) + Propofol Injection + Sufentanil Injection, Normal Saline (nasal spray) + Dexmedetomidine Injection (intravenous) + Propofol Injection + Sufentanil Injection, Regular sedation protocol
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shiyou Wei
Colon Cancer, IBS
Patient Satisfaction With Propofol for Out Patient Colonoscopy
The primary purpose of this study is to determine if patient satisfaction with propofol is better than with non-propofol anesthesia for outpatient colonoscopies.
- Conditions
- Colon Cancer, IBS, Polyps
- Trial name
- NCT02937506
- Testing
- Propofol, Fentanyl Plus Midazolam
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mount Carmel Health System
Myocardial Ischemia
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
This study evaluates the myocardial protection against perioperative ischemia comparing two standard anesthetic regimes in diabetic patients undergoing elective cardiac surgery.
- Trial name
- OPT (NCT02407626)
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Triemli Hospital
Gastric Cancer
The Effect of Dexmedetomidine During Opioid Free Anesthesia on Postoperative Recovery After Gastrectomy
"Want to know the effect of dexmedetomidine during opioid free anesthesia on postoperative recovery after gastrectomy. Patients undergoing open gastrectomy are divided into dexmedetomidine group and control(remifentanil) group…
- Trial name
- NCT04529135
- Testing
- Dexmedetomidine, Remifentanil
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Gangnam Severance Hospital
Stress Reaction, Opioid Use
Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.
Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human…
- Trial name
- NCT03248076
- Testing
- Fentanyl Citrate
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Papanicolaou Hospital
Cardiac Arrest, Acute Coronary Syndrome
Mild Therapeutic Hypothermia for Patients With Acute Coronary Syndrome and Cardiac Arrest Treated With PCI
Mild Therapeutic Hypothermia for Patients with Acute Coronary Syndrome and Cardiac Arrest Treated with Percutaneous Coronary Intervention (UNICORN) study is designed to determine whether mild therapeutic hypothermia (MTH) applied…
- Trial name
- UNICORN (NCT02611934)
- Testing
- Mild Therapeutic Hypothermia (MHT)
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jacek Kubica
Children Requiring Sedation for MRI/CT
The Incidence and Nature of Adverse Events During Pediatric Sedation for MRI/CT in One Korean University Hospital: Prospective Study
Sedation and anesthesia for which to perform diagnostic imaging represents a rapidly growing field of practice, especially in children. Propofol is the most common sedative drug administered for MRI/CT.
- Trial name
- NCT01855555
- Testing
- sedation with propofol
- Where
- South Korea
- Volunteers
- 2,948 people
- Sponsor
- Yonsei University
Total Knee Arthroplasty
Intraoperative VR for Older Patients Undergoing TKA
The objective of this study is to investigate whether the use of virtual reality (VR) during total knee arthroplasty (TKA) can facilitate reductions in intraoperative sedative requirements while maintaining high levels of patient…
- Trial name
- NCT04748549
- Testing
- Virtual Reality Immersive Relaxation, Immersive Audio Experience
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
PONV, Opioid Sparing Anaesthesia
Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery
In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and…
- Trial name
- NCT04706897
- Testing
- Dexmedetomidine, ketamine and lidocaine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Intubation, Intratracheal, Obesity
Thyromental Height Test as a New Method for Prediction of Difficult Intubation in Obese Patients
The main objective of this trial is to assess the clinical usefulness of thyromental height test (TMHT) in prediction of difficult intubation in obese patients scheduled for elective surgical procedures.
- Conditions
- Intubation, Intratracheal, Obesity, Predictive Value of Tests
- Trial name
- NCT04439487
- Testing
- Anthropometric measurements during routine preoperative visit, Assesment of intubation parameters during induction of general anaesthesia
- Where
- 2 sites in Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Thyroid Surgeries, Intraoperative Analgesic Use
qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery
The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative…
- Conditions
- Thyroid Surgeries, Intraoperative Analgesic Use, Anesthesia Depth Monitoring
- Trial name
- NCT07445659
- Testing
- Connox EEG Monitoring, standard anesthesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Cardiac Disease, Anesthesia
The Use of Remimazolam for TEE
This is a prospective randomized study. The purpose of this study is to compare the use of remimazolam vs propofol (standard practice) for transesophageal echocardiogram (TEE).
- Trial name
- NCT07829458
- Testing
- Remimazolam, Propofol
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anesthesia Recovery Period, Pain, Postoperative
Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery
The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients…
- Trial name
- NCT00681174
- Testing
- Morphine, oxycodone, Paravertebral block
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- University of Parma
Depressive Disorder
Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients
In this clinical study, propofol was used as the positive control, and a randomized controlled trial design was used to observe the effects of ciprofol anesthesia on learning and memory function and antidepressant efficacy in…
- Trial name
- NCT05266560
- Testing
- ciprofol, Propofol
- Volunteers
- 390 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University