Clinical trials: Pregabalin, completed
Epilepsy
Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures
This study will evaluate the long term safety and efficacy of pregabalin (Lyrica) when administered by itself (without any other anti-epileptic medication) to epilepsy patients for the treatment of partial seizures.
- Trial name
- NCT00596466
- Testing
- pregabalin
- Where
- 44 sites in United States, Czechia and 2 more
- Volunteers
- 75 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Primary Total Knee Arthroplasty
Effects of Pregabalin on Pain After Total Knee Arthroplasty
Total knee arthroplasty can cause severe postoperative pain, and patients typically receive oral opioid analgesics for over 2 weeks.
- Trial name
- NCT01333956
- Testing
- Pregabalin 50mg, Pregabalin 100mg, Pregabalin 150mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hospital for Special Surgery, New York
Post Herpetic Neuralgia
Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia
The purpose of the study is to explore the safety and efficacy of a new once a day pregabalin formulation versus placebo for patients with post herpetic neuralgia (Shingles)
- Trial name
- NCT01270828
- Testing
- Pregabalin
- Where
- 146 sites in United States, Bulgaria and 15 more
- Volunteers
- 806 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Opioid Use
A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery
The primary objective of this trial is to determine whether the combination of three non-opioid analgesics (multimodal analgesia) can significantly reduce or eliminate the need for opioids after ambulatory surgery.
- Trial name
- NCT04015908
- Testing
- Celecoxib, Acetaminophen, Pregabalin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Neuropathy, Diabetic
A Study In Patients With Neuropathic Pain From Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to determine whether gabapentin enacarbil (XP13512/GSK1838262), hereafter referred to as GEn is effective in the treatment of neuropathic pain associated with diabetic peripheral neuropathy(DPN)
- Trial name
- NCT00643760
- Testing
- GEn 1200mg/day, GEn 2400mg/day, GEn 3600mg/day
- Where
- 90 sites in United States
- Volunteers
- 421 people
- Sponsor
- XenoPort, Inc.
Diabetic Peripheral Neuropathic Pain
Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management
This is a multicenter, randomized, open-label, parallel, Phase 4 clinical trial to compare efficacy and safety of gabapentin/B-complex versus pregabalin in diabetic peripheral neuropathy pain (DPNP) management.
- Trial name
- NCT01364298
- Testing
- Gabapentin/B-complex, Pregabalin
- Where
- Mexico
- Volunteers
- 353 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Diabetic Neuropathy, Painful
A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the efficacy and safety of PF-05089771 as a monotherapy and as an add-on to pregabalin for the treatment of painful diabetic peripheral neuropathy (DPN)
- Trial name
- NCT02215252
- Testing
- PF-05089771 150 mg, Pregabalin 300 mg, PF-05089771 150 mg + Pregabalin 300 mg
- Where
- 32 sites in United States
- Volunteers
- 141 people
- Sponsor
- Pfizer
Idiopathic Restless Legs Syndrome
Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients
This purpose of this study is to investigate the efficacy and tolerability of pregabalin in treating idiopathic RLS patients for up to 12 months.
- Trial name
- RLS (NCT00806026)
- Testing
- pramipexol, Pregabalin
- Where
- 110 sites in United States, Austria and 7 more
- Volunteers
- 731 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Intervertebral Disk Displacement, Disk Prolapse
Analgetic and Anxiolytic Effect of Preoperative Pregabalin
The purpose of this study is to determine whether the use of oral pregabalin 150 mg as premedication reduces the amount and degree of postoperative pain.
- Trial name
- NCT00353704
- Testing
- pregabalin, morphine
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Asker & Baerum Hospital
Low Back Pain, Pain
Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)
The purpose of this study is to determine if a stepped-care intervention makes pain symptoms better and reduces activity limitations because of pain. Our two primary hypotheses are that in OIF/OEF veterans with chronic pain: 1.
- Conditions
- Low Back Pain, Pain, Pain, Intractable
- Trial name
- ESCAPE (NCT00386243)
- Testing
- Cognitive behavioral therapy, Pain self-management program, Co-Analgesic Therapy
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- VA Office of Research and Development
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Pain, Peripheral Neuropathy
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel
This randomized pilot clinical trial studies pregabalin in preventing acute pain syndrome in patients receiving paclitaxel. Pregabalin may control the pain caused by cancer treatment.
- Trial name
- NCT01637077
- Testing
- pregabalin, questionnaire administration
- Where
- 6 sites in United States
- Volunteers
- 46 people
- Sponsor
- Academic and Community Cancer Research United
Nonspecific Pain Post Traumatic Injury
MAST Trial: Multi-modal Analgesic Strategies in Trauma
This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared [original multimodal pain…
- Trial name
- MAST (NCT03472469)
- Testing
- Acetaminophen IV/PO, Acetaminophen PO, Ketorolac
- Where
- United States
- Volunteers
- 1,561 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Diseases, Spinal Cord Injuries
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis…
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neuralgia, Pain
- Trial name
- NCT01202227
- Testing
- pregabalin
- Where
- 26 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pain Associated With Fibromyalgia
Special Investigation of Pregabalin for Fibromyalgia (Regulatory Post Marketing Commitment Plan)
To collect the efficacy and safety information of Pregabalin on Fibromyalgia patients related to their appropriate use in daily practice.
- Trial name
- NCT01773993
- Testing
- Pregabalin
- Volunteers
- 534 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy
Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica
Phase 4, double-blind, placebo-controlled, four treatment, four sequence crossover study comparing simulated driving performance, daytime sedation and cognition in healthy volunteers administered therapeutic doses of Gralise®…
- Trial name
- NCT03179345
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Depomed
Neuralgia, Spinal Cord Injuries
A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
The purpose of this study is to evaluate if pregabalin relieves nerve pain associated with spinal cord injury compared to placebo (pill that contains no active medicine).
- Trial name
- NCT00407745
- Testing
- pregabalin
- Where
- 67 sites in United States, Chile and 8 more
- Volunteers
- 220 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Focal Epilepsy
A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice
Assessment of the efficacy under daily clinical conditions of the new antiepileptic drugs (AEDs) gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine and topiramate, used as first-choice combination…
- Trial name
- NCT00855738
- Testing
- Gabapentin, Lamotrigine, Levetiracetam, Pregabalin, Oxcarbacepine, Tiagabine, Topiramate, Zonisamide
- Volunteers
- 111 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pain, Postoperative, Hernia, Inguinal
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
The purpose of this study is to test whether pregabalin added to the standard of care with dosing starting preoperatively and continuing for 1 week post surgery will decrease the intensity of acute post-operative pain following…
- Trial name
- NCT00551135
- Testing
- Pregabalin
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 425 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.