Clinical trials: Oxaliplatin
Metastatic Colorectal Cancer
JS212 Combination Therapies in Metastatic Colorectal Cancer
This is an open-label, multicenter Phase 2 clinical study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of JS212-based combination therapies in patients with metastatic colorectal…
- Trial name
- NCT07503756
- Testing
- JS212, Capecitabine, Bevacizumab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Esophageal Cancer, Gastric (Stomach) Cancer
Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma
Purpose of the Study: This clinical study investigates whether a shorter or longer duration of systemic therapy before local treatment (surgery or radiation) results in better disease control in patients with esophageal or…
- Conditions
- Esophageal Cancer, Gastric (Stomach) Cancer, Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
- Trial name
- OMEC-5 (NCT07000253)
- Testing
- Chemotherapy, Targeted Systemic Therapy, Immunotherapy
- Where
- 5 sites in Netherlands, Norway and 1 more
- Volunteers
- 290 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophagus Cancer
Chemoradiation Versus Esophagectomy for Locally Advanced Esophageal Cancer
The aim of this study is to compare outcomes in Chinese patients with locally advanced resectable esophageal squamous cell cancer who have received either surgery or definitive chemoradiation (CRT) by the randomized, open-label…
- Trial name
- CELAEC (NCT02972372)
- Testing
- CRT, surgery
- Where
- 2 sites in China
- Volunteers
- 196 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Cancer of Pancreas
Induction Chemotherapy, FOLFIRINOX Followed With Concurrent Capecitabine and Radiation Therapy in Inoperable Locally Advanced Cancer of the Pancreas
This prospective cohort, phase II, trial is studying induction chemotherapy combination, FOLFIRINOX regimen, consisted of oxaliplatin, irinotecan, leucovorin and fluorouracil (5-FU), for 4 cycles, followed by consolidation…
- Trial name
- NCT02311439
- Testing
- FOLFIRINOX + CRT
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Unresectable Hepatocellular Carcinoma, Hepatocellular Carcinoma by BCLC Stage
A Trial of Hepatic Arterial Infusion Combined With Bevacizumab and Sintilimab for Unresectable A-staged Hepatocellular Carcinoma in BCLC Classification (D-TRIPLET)
This study was designed to evaluate the effectiveness and safety of hepatic arterial infusion chemotherapy combined with Bevacizumab and Sintilimab (Triplet-combined Therapy) for Unresectable A-staged Hepatocellular Carcinoma in…
- Trial name
- NCT05214339
- Testing
- Hepatic Arterial Infusion(mFOLFOX7) combined with Bevacizumab and Sintilimab
- Where
- 5 sites in China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer
To increase the efficacy of neoadjuvant PD-1/PD-1 checkpoint inhibitor in local advanced rectal cancer (LARC), we propose preoperative arterial infusion of Tirellizumab and oxaliplatin followed by tumor artery embolization with…
- Trial name
- NCT05957016
- Testing
- CIETAI-R
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Third Military Medical University
Low Rectal Cancer
Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer
This is an open-label, prospective, multicenter phase II clinical trial to evaluate modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph nodes) combined with…
- Trial name
- mRCAT (NCT05972655)
- Testing
- Modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sir Run Run Shaw Hospital
Biliary Tract Cancer
A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy Failure
This trial is a registrational Phase III, randomized, open-label, multicenter study to evaluate the efficacy and safety of BL-M07D1 in patients with HER2-expressing locally advanced or metastatic biliary tract cancer after…
- Trial name
- NCT07606599
- Testing
- BL-M07D1, Oxaliplatin, Calcium levofolinate
- Where
- 2 sites in China
- Volunteers
- 398 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Metastatic Colorectal Carcinoma
A Clinical Trial of LBL-024 Combination Drug in Patients With Metastatic Colorectal Carcinoma
This study is an open-label, multi-center Phase Ib/II clinical trial evaluating the safety and efficacy of LBL-024 in combination with other drugs for the treatment of metastatic colorectal carcinoma (mCRC), aiming to evaluate…
- Trial name
- NCT07791758
- Testing
- LBL-024 for Injection, Bevacizumab injection, Oxaliplatin injection
- Where
- 10 sites in China
- Volunteers
- 369 people
- Sponsor
- Nanjing Leads Biolabs Co.,Ltd
Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Stomach
Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer
This randomized phase II trial studies combination chemotherapy when given together with vismodegib to see how well it works compared with combination chemotherapy without vismodegib in treating patients with advanced stomach…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Stomach, Recurrent Gastric Cancer, Stage IIIA Gastric Cancer
- Trial name
- NCT00982592
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- 30 sites in United States
- Volunteers
- 124 people
- Sponsor
- National Cancer Institute (NCI)
Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder
Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies
This study is being done to determine the dose of a chemotherapy drug (irinotecan [irinotecan hydrochloride]) that can be tolerated as part of a combination of drugs.
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder, Adenocarcinoma of Unknown Primary, Adult Primary Cholangiocellular Carcinoma
- Trial name
- NCT01643499
- Testing
- oxaliplatin, irinotecan hydrochloride, leucovorin calcium
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- University of Chicago
Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma
A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer
Precision Promise is a multi-center, seamless Phase 2/3 platform trial designed to evaluate multiple regimens in metastatic pancreatic cancer.
- Trial name
- NCT04229004
- Testing
- Gemcitabine combined with nab-paclitaxel, Dose -mFOLFIRINOX, Dose - Pamrevlumab combined with gemcitabine and nab-paclitaxel
- Where
- 25 sites in United States
- Volunteers
- 502 people
- Sponsor
- Pancreatic Cancer Action Network
Colorectal Cancer
OPTIMOX1 in Chinese mCRC Patients
Previous OPTIMOX1 study investigated the use of oxaliplatin discontinuation and reintroduction in a novel stop-and-go strategy. Previously untreated patients were randomly assigned to either FOLFOX4 administered every 2 weeks…
- Trial name
- NCT01023633
- Testing
- Oxaliplatin, LV, 5-FU
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Colorectal Tumors, Colorectal Neoplasms
Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004
Background: Colorectal cancer is a common cancer in the Unites States (U.S.) It causes the second most cancer-related deaths. The drug avelumab and vaccine Ad-CEA together help the immune system fight cancer.
- Conditions
- Colorectal Tumors, Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Adenocarcinoma
- Trial name
- NCT03050814
- Testing
- Avelumab, Ad-CEA vaccine, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Peritoneal Carcinomatosis
Study of Efficacy and Safety of Laparoscopic Intra-abdominal Chemotherapy (PIPAC) Performed in Patients With Peritoneal Carcinomatosis From Colorectal, Ovarian, Gastric Cancer and Primary Peritoneal Tumors
Single center, open label, phase I-II, non-randomized, two-cohort, repeated single dose study to explore the feasibility, efficacy, safety, and Overall Response Rate (ORR) of oxaliplatin, or cisplatin and doxorubicin when given…
- Trial name
- PI-CaP (NCT02604784)
- Testing
- Pressurized IntraPeritoneal Air-flow Chemotherapy (PIPAC) fixed repeated dose, Pressurized IntraPeritoneal Air-flow Chemotherapy (PIPAC) increasing single dose
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Gastric Cancer
Phase II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumab in Advanced Gastric Cancer
This study is a single center, phase II study, to evaluate the effectiveness and safety of PD-1 Antibody(Tislelizumab) Plus Irinotecan Combined With POF(paclitaxel plus oxaliplatin plus 5-fluorouracil plus leucovorin) , in the…
- Trial name
- NCT06197438
- Testing
- Tislelizumab, Oxaliplatin, Levo-Leucovorin
- Volunteers
- 36 people
- Sponsor
- Fujian Cancer Hospital
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer
RATIONALE: Everolimus may stop the growth of stomach or esophageal cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, and oxaliplatin, work in different ways to stop…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Diffuse Adenocarcinoma of the Stomach, Intestinal Adenocarcinoma of the Stomach
- Trial name
- NCT01231399
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- City of Hope Medical Center
Rectal Cancer
A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk
A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk
- Trial name
- NCT04664504
- Testing
- Concurrent Chemoradiotherapy Radiotherapy, Short-course Radiotherapy, Local dose increase of Short-course Radiotherapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jing Jin, M.D.
GI Cancers
Modified Capecitabine and Oxaliplatin (mCAPOX) for Patients With GI Malignancies
This study is a single arm, non-randomized feasibility study with tolerability and toxicity evaluation as primary endpoints which seeks to determine if a modified administration schedule of capecitabine with oxaliplatin will…
- Trial name
- NCT06648785
- Testing
- oxaliplatin, Fluoropyrimidine
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont Medical Center
Metastases, Colorectal Neoplasms
Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy.
Primary Objective : Compare the risk of occurrence of Grade3-4 cumulative peripheral sensory neuropathy (PSN) relative to cumulative dose of oxaliplatin between treatment group and placebo group.
- Conditions
- Metastases, Colorectal Neoplasms, Colorectal Carcinoma
- Trial name
- NCT00305188
- Testing
- Xaliproden (SR57746A), Oxaliplatin, 5-Fluorouracil
- Where
- 13 sites in United States, Argentina and 11 more
- Volunteers
- 879 people
- Sponsor
- Sanofi
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