Clinical trials: Midazolam
Postoperative Cognitive Dysfunction, Post Operative Delirium
Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination
Postoperative cognitive dysfunction (POCD) is one of the most common complications after anesthesia, with a prevalence of approximately 12% and a higher prevalence of up to 41.4% in older surgical patients during the entire…
- Trial name
- NCT07074262
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Beni-Suef University
Postoperative Pain
Fentanyl Versus Midazolam As Additives To Bupivacaine In Ultrasound Guided Transversus Abdominis Plane Block
Pain triggers a complex biochemical and physiological stress response leading to impairment of pulmonary, immunological and metabolic functions.
- Trial name
- NCT04426617
- Testing
- Ultrasound Guided Transversus Abdominis Plane Block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Bassant M. Abdelhamid
Urethrocutaneous Fistulas
2-octyl Cyanoacrylate for Closure of Urethrocutaneous Fistula.
Urethrocutaneous fistulae (UCF) represent one of the most frequent causes of morbidity after urethroplasty. Hypospadias can be repaired using different surgical techniques, but regardless of technique, the incidence of UCF ranges…
- Trial name
- NCT02115191
- Testing
- 2-octylcyanoacrylate, Surgical reintervention
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Mexicano del Seguro Social
VA Drug Interactions
Study to Evaluate the Effect of Delafloxacin on the Pharmacokinetics of Midazolam in Healthy Subjects
The purpose of this study is to evaluate the effect of repeated doses of oral delafloxacin on the pharmacokinetic (PK) profile of a single oral dose of midazolam.
- Trial name
- NCT02505997
- Testing
- Midazolam, Delafloxacin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Melinta Therapeutics, Inc.
Behavior Problem
Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children
The goal of this clinical trial is to learn the effect of dexmedetomidine premedication in postoperative negative behavior changes in children compared to midazolam premedication.
- Trial name
- NCT06417125
- Testing
- Dexmedetomidine Hydrochloride, Midazolam, normal Saline
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Fujian Provincial Hospital
Bladder Tumor, Postoperative Cognitive Dysfunction
The Assessment of POCD After TURBT Under Spinal Anesthesia
This study evaluates the influence of premedication on cognitive functions in patients undergoing transurethral resection of bladder tumor under spinal anesthesia.
- Trial name
- NCT03029676
- Testing
- benzodiazepines, opioid, spinal anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Drug Safety
Use of Intranasal Midazolam to Reduce Stress and Procedural Pain in Premature Infants During Routine ROP Examination.
The goal of this study is to learn about the safety and effectiveness of intranasal midazolam in newborns and infants born prematurely, undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06889376
- Testing
- Intranasal midazolam administration via the DART™ intranasal atomization device along with routine comfort care.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Sedation, Dexmedetomidine
Sedation With Dexmedetomidine or Midazolam in Combination With Propofol for Removal of Double-J Ureteral Stent
The aim of this study is to compare the efficacy of intravenous sedation using propofol alone or in combination with dexmedetomidine or midazolam for the removal of double J (D-J) ureteral stent.
- Conditions
- Sedation, Dexmedetomidine, Midazolam, Propofol
- Trial name
- NCT07580768
- Testing
- Propofol, Propofol and Dexmedetomidine, Propofol and Midazolam
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Drug Interactions
Open-Label, Multiple-Dose, Non-Randomized Study to Assess Drug-Drug Interactions of Proellex® in Female Subjects
This study will assess possible drug-drug interactions with specific isoenzymes over a total study duration of 6-8 weeks. Blood samples collected pre and post-dose, and urine samples collected post dose will be analyzed.
- Trial name
- NCT00741468
- Testing
- Proellex, CYP1A2 probe, CYP2C9 probe
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Dental Anxiety
Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment
The aim of the study is to evaluate the effect of nebulized Midazolam, Dexmedetomidine, and their combination as procedural, moderate sedative agents in preschoolers undergoing dental treatment.
- Trial name
- NCT03827408
- Testing
- Midazolam group (MDZ), Dexmedetomidine group (DEX), Combination of Midazolam and Dexmedetomidine (MDZ/DEX)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Nourhan M.Aly
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Abuse, Drug
Abuse Potential of Intravenous Remimazolam Compared to Midazolam and Placebo in Recreational CNS Depressant Users
A double-blind, randomized crossover study to assess the subjective abuse potential of intravenous remimazolam compared to midazolam and placebo in recreational CNS depressant users
- Trial name
- NCT04110535
- Testing
- Remimazolam, Midazolam, Saline
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Paion UK Ltd.
Umbilical Hernia, Spinal Aneshtesia
Spinal Or General Anesthesia For Umblical Hernia Surgery
In this study, the investigators compared spinal anesthesia under ketofol (ketamine-propofol combination) sedation with general anesthesia in terms of intraoperative and postoperative hemodynamics, respiratory parameters and cost…
- Conditions
- Umbilical Hernia, Spinal Aneshtesia, General Anesthesia
- Trial name
- NCT06426225
- Testing
- General Anesthesia, Spinal Aneshtesia
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ankara City Hospital Bilkent
Mechanically Ventilated and Intubated Subjects
A Safety and Efficacy Study of Dexmedetomidine in ICU Patients Requiring Continuous Sedation
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine in ICU subjects who are initially intubated, mechanically ventilated and require sedation for beyond 24 hours.
- Trial name
- NCT00216190
- Testing
- Dexmedetomidine HCL Injection, Midazolam Injection
- Where
- 96 sites in United States, Argentina and 3 more
- Volunteers
- 420 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Tonsillectomy
Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents
Pain and anxiety have a direct correlation. Patients who experience anxiety are more susceptible to feeling pain, and patients who experience pain are more likely to have a component of anxiety associated with their pain.
- Trial name
- NCT03239743
- Testing
- Virtual Reality, Midazolam
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Colitis, Ulcerative, Crohn Disease
Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
The purpose of this study is to evaluate in a step-wise approach the disease drug-drug interaction (DDI) potential for vedolizumab to indirectly affect the exposure of cytochrome P-450 (CYP) substrate drugs by modulating…
- Trial name
- NCT02760615
- Testing
- Caffeine, Losartan, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Multiple Sclerosis, Fatigue
Ketamine for Treatment of MS Fatigue
Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disease of the central nervous system and, after trauma, is the most common cause of disability in young adults, affecting more than 400,000 individuals…
- Trial name
- NCT03500289
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Healthy Participants
Pharmacokinetic Interaction Trial of Clofutriben With Midazolam and Prednisolone
Drug: 2 single oral doses of midazolam, 2 single oral doses of prednisolone , and clofutriben once daily for 16 days.
- Trial name
- DDI (NCT07226635)
- Testing
- midazolam, clofutriben once daily for 16 days, 2 single oral doses of prednisolone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sparrow Pharmaceuticals
Rhythm; Disorder
Audiovisuell Distraction Via 2d Videoglasses During Catheter Ablation Procedures in Cardiac Rhythm Disorders.
In this randomized controlled trial, amount of sedation exposure and patient satisfaction is evaluated in patients undergoing catheter ablation for rhythm disorders via an audiovisual distraction.
- Trial name
- NCT04873076
- Testing
- Audiovisual distraction using 2d video glasses from HappyMed GmbH
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital, Essen