Clinical trials: Lidocaine
Turbinate Surgery, Sphenopalatine Block
Blocking Sphenopalatine Ganglion by Intranasal Lidocaine Spray in Partial Turbinectomy Surgeries
Nasal turbinectomy surgeries are usually done as day case surgeries as most patients are young with unremarkable comorbidities. However, considerations are still present towards patients of old age or those suffering from obesity…
- Trial name
- SPG block (NCT07299630)
- Testing
- Balanced anesthesia, Lidocaine spray
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Renal Pelvis and Ureter Urothelial Carcinoma
Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma
This clinical trial tests how well office based ureteroscopy utilizing a single use digital, flexible ureteroscope works for the assessment of upper tract urothelial carcinoma.
- Trial name
- NCT07630155
- Testing
- Analgesic Agent, Electronic Health Record Review, Lidocaine Topical
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan Rogel Cancer Center
Hysterosalpingography-Related Pain
Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial
Hysterosalpingography (HSG) is commonly performed during infertility evaluation and may cause pain during cervical manipulation, uterine distension, and contrast-medium injection.
- Trial name
- HSG-PAIN (NCT07792668)
- Testing
- Indomethacin 100Mg Suppository, Lidocaine %2 ampoule
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Post Tonsillectomy Pain, Post Operative Analgesia
Transnasal Sphenopalatine Ganglion Block for Postoperative Pain and Recovery in Tonsillectomy (TONwoPA)
The aim of this clinical trial is to evaluate the effectiveness of transnasal transmucosal sphenopalatine ganglion block in reducing post-tonsillectomy pain.
- Conditions
- Post Tonsillectomy Pain, Post Operative Analgesia, Opioid Consumption, Sphenopalatine Ganglion Block
- Trial name
- TONwoPA (NCT07370129)
- Testing
- Transnasal Transmucosal Sphenopalatine Ganglion Block, Lidocaine %5, Saline (0.9% NaCl)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ankara University
Head & Neck Cancer, Oral Mucositis
A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer.
Most patients who receive radiation therapy for head and neck cancer develop painful sores in the mouth called oral mucositis. For many of them, these sores are severe and result in debilitating pain.
- Trial name
- BEAM-Pain (NCT07672236)
- Testing
- BupiZenge 25 mg, Lidocaine viscous 2%
- Where
- 11 sites in Denmark, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- OncoZenge AB
Emergence Agitation, Emergence Delirium
Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy
Emergence agitation is a frequent recovery complication in young children following general anesthesia with sevoflurane. It is characterized by confusion, crying, disorientation, and non-purposeful thrashing during early…
- Conditions
- Emergence Agitation, Emergence Delirium, Postoperative Pain
- Trial name
- NCT07871266
- Testing
- Lidocaine, 0.9% Normal Saline
- Volunteers
- 60 people
- Sponsor
- Assiut University
Malignant Pleural Neoplasm
EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement
This phase II trial investigates the effect of EXPAREL compared to lidocane as a local anesthetic in patients who are undergoing pleuroscopy with pleural biopsy and indwelling pleural catheter placement.
- Trial name
- NCT05044468
- Testing
- Lidocaine, Liposomal Bupivacaine, Questionnaire Administration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Breast Hypertrophy
ESPB Versus Intravenous Lidocaine for Pain After Mastopexy
Elective breast reduction surgery is associated with moderate-to-severe postoperative pain and a risk of developing chronic postsurgical pain.
- Trial name
- NCT07687069
- Testing
- Ultrasound - guided Erector Spine Plane Block (ESPB), Intraoperative intravenous lidocaine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block
Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis
Local anesthetic is used to numb a tooth before a root canal treatment. In lower back teeth with irreversible pulpitis (a painful, inflamed tooth nerve), the standard numbing injection near the jaw nerve, called an inferior…
- Trial name
- ARTLID-IP (NCT07869394)
- Testing
- Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Rehman Medical Institute - RMI
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Ehlers-Danlos Syndrome, Low Back Pain
The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients
1. Specific Aim: To show the safety and efficacy of prolotherapy injection for chronic sacroiliac and myofascial lumbar pain while standardizing an ultrasound guided injection technique 2.
- Conditions
- Ehlers-Danlos Syndrome, Low Back Pain, Sacroiliac Instability
- Trial name
- NCT05279937
- Testing
- Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution
- Sponsor
- Tulane University
Migraine Disorders, Medication Overuse Headache
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Migraine is among the leading causes of disability worldwide. Inappropriate use of acute medications in the setting of primary headache, particularly migraine can result in a debilitating condition known as medication overuse…
- Conditions
- Migraine Disorders, Medication Overuse Headache, Greater Occipital Nerve Block
- Trial name
- GONB_MOH (NCT07568496)
- Testing
- Lidocaine 2% and Methylprednisolone 80 mg
- Where
- 3 sites in Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Tracheal Extubation, Cough
Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy
This randomized, double-blind clinical trial will compare the effects of remifentanil alone and remifentanil combined with intravenous lidocaine on the quality of tracheal extubation in adult patients undergoing elective…
- Trial name
- NCT07857356
- Testing
- remifentanil, Lidocaine %2 ampoule
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Postoperative Pain, Cholelithiasis
Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (gallbladder removal) is one of the most common abdominal operations performed worldwide. Despite its minimally invasive approach, up to half of patients experience notable postoperative pain, which…
- Trial name
- NCT07865455
- Testing
- Labetalol, Magnesium Sulfate, Lidocaine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Neuroma, Phantom Limb Pain After Amputation
Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Conditions
- Neuroma, Phantom Limb Pain After Amputation, Stump Pain, Platelet-rich Plasma (PRP)
- Trial name
- PRP-NEUROMA (NCT07624890)
- Testing
- Platelet-Rich Plasma (PRP) Injections, Local Anesthetic Injection
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Catheterization, Central Venous, Pain, Procedural
Comparison of Local Infiltration Anesthesia and Superficial Cervical Plexus Block in Ultrasound-Guided Internal Jugular Vein Catheterization: Efficacy, Duration, and Local Anesthetic Volume
Internal jugular vein (IJV) catheterization is a common invasive procedure performed under ultrasound (USG) guidance. Providing effective analgesia during the procedure is essential for patient comfort.
- Conditions
- Catheterization, Central Venous, Pain, Procedural, Internal Jugular Vein Cannulation
- Trial name
- NCT07841782
- Testing
- Lidocaine HCl 1%
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Kayseri City Hospital
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Mid Face Volume Deficit
A Study to Assess Safety and Effectiveness of HArmonyCa Lidocaine Injectable Gel for Restoration and/or Creation of Mid-Face Volume in Adult Participants
The cumulative effect of aging and environmental exposures (ie, ultraviolet, infrared, and visible light radiation and pollution) leads to wrinkles, discoloration, laxity, and roughness of sun exposed skin.
- Trial name
- NCT07032597
- Testing
- HArmonyCa Lidocaine Injectable Gel, Restylane® Perlane® Lidocaine
- Where
- 9 sites in China
- Volunteers
- 252 people
- Sponsor
- AbbVie