Clinical trials: Lidocaine, open to volunteers
Cholecystectomy, Laparoscopic, Gynecologic Surgical Procedures
Synergistic Effect of Intravenous Lidocaine on Anesthetic Induction and Emergence in Patients Undergoing Laparoscopic Cholecystectomy or Gynecological Surgery
This study aims to evaluate the effect of intravenous lidocaine on consciousness changes during anesthesia in patients undergoing laparoscopic cholecystectomy or gynecologic surgery.
- Conditions
- Cholecystectomy, Laparoscopic, Gynecologic Surgical Procedures, Anesthesia and Procedure Related Time Intervals
- Trial name
- Li (NCT07193836)
- Testing
- Normal Saline (0.9% NaCl), Lidocaine, Lidocaine Bolus + Infusion
- Where
- China
- Volunteers
- 195 people
- Sponsor
- General Hospital of Ningxia Medical University
Pain Perception
Effectiveness of Vibratory Versus Cold Stimuli on Pain Perception in Children
Local anesthesia is an anxiety-provoking procedure. Pain control is important for effective behavior guidance, specially among pediatric patients.
- Trial name
- NCT06841601
- Testing
- topical anesthetic gel, Vibration, Cold pack
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Thoracal Epidural Block, Echocardiography
Effect of Thoracic Epidural Anesthesia on Left Ventricular Functions: A Strain Echocardiography Study
Post-thoracic surgery pain management thoracic epidural catheter is the most commonly used method. Thoracic epidural anesthesia, in which cardiac sympathetic nerves (T1-T5) are involved in neural blockade, is the focus of our…
- Trial name
- TEA-strain (NCT06770790)
- Testing
- strain echocardiography
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Kidney Disease, End-Stage, Kidney Transplant
Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes.
- Conditions
- Kidney Disease, End-Stage, Kidney Transplant, Kidney, Kidney Disease
- Trial name
- NCT07678073
- Testing
- Sevoflurane General Anesthesia, Bupivacaine and Morphine for Combined Spinal-Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- University of Gaziantep
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Cystectomy, Myomectomy
Lidocaine for LESS Postoperative Shoulder Pain Alleviation
Objective: To evaluate the efficacy of subdiaphragmatic spray of 0.08% lidocaine in relieving postoperative acute pain and psychological status of patients undergoing single-port laparoscopic surgery for benign gynecological…
- Trial name
- NCT07537127
- Testing
- subdiaphragmatic lidocaine sprayed, standard ERAS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Hip Osteoarthritis
Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain
Prospective, single-center that may go on to being multicenter, randomized trial comparing platelet rich plasma (PRP) versus corticosteroid injection for the treatment of symptoms of Hip osteoarthritis.
- Trial name
- NCT06793982
- Testing
- Platelet Rich Plasma Joint Injection, Corticosteroid Injection
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
Pain, Procedural, Minor Laceration
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
This trial is a double-blind randomized controlled clinical trial of adults and children (ages 7 to less than 70 years). Patients who present to the ED and who undergo minor bedside procedures that require local anesthesia will…
- Conditions
- Pain, Procedural, Minor Laceration, Abscess
- Trial name
- INK-MP (NCT06284473)
- Testing
- Ketamine, Saline
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Loyola University
Non-Small Cell Lung Cancer, Recurrence
Lidocaine Decreases Postoperative Lung Cancer Reoccurance and Metatasis Risk
The goal of this clinical trial is to explore if perioperative lidocaine infusion decreases disease reoccurrence and metastasis risk in non-small cell lung cancer patients.
- Conditions
- Non-Small Cell Lung Cancer, Recurrence, Survival Analysis
- Trial name
- LidCRM (NCT07347977)
- Testing
- Lidocaine (drug)
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Hemodynamics Instability, Post Operative Pain
Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy
Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications.
- Conditions
- Hemodynamics Instability, Post Operative Pain, Gastrointestinal Dysfunction, Cholecystitis
- Trial name
- NCT06740903
- Testing
- inj. dexmedetomidine infusion @ 0.2-0.4 μg/kg/h, inj. lignocaine infusion @1-2 mg/kg/h
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Labor Induction
Pain Control for Cervical Ripening Balloon
No standard of care exists for pain management during cervical ripening balloon placement. The purpose of this study is to evaluate if vaginal topical lidocaine reduces pain related to cervical ripening balloon placement during…
- Trial name
- NCT07268118
- Testing
- topical vaginal application lidocaine gel
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Beth Israel Deaconess Medical Center
Myofacial Pain, Pelvic Pain
Lidocaine-prilocaine Cream as Analgesia for In-office Levator Muscle Trigger Point Injections
Levator muscle trigger point injections (TPI) are a commonly performed procedure in the office for treatment of pelvic pain related to pelvic floor muscles. The most common concern related to in-office TPI is pain.
- Trial name
- NCT07778043
- Testing
- Lidocaine-Prilocaine Cream 2.5-2.5%, Permeation-enhancing vanishing cream
- Volunteers
- 36 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Cervical Radiculopathy, Cervical Radicular Pain
Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Proprioception in Patients With Chronic Cervical Radiculopathy
Cervical radiculopathy is a common condition caused by irritation or compression of cervical nerve roots, often leading to unilateral neuropathic pain and functional impairment.
- Conditions
- Cervical Radiculopathy, Cervical Radicular Pain, Proprioception
- Trial name
- NCT07307846
- Testing
- Interlaminar Epidural Steroid Injection (ILESI)
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Marmara University
Pain During Saline Infusion Sonogram
Paracervical Block for Pain Reduction in Saline Infusion Sonograms
Inadequate pain management during gynecologic procedures is a growing women's health concern, especially as it reduces access to care for patients who may subsequently avoid further treatment.
- Trial name
- NCT07048769
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Montefiore Medical Center
Emergency Abdominal Surgery, Opioid Sparing Anaesthesia
Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery.
- Trial name
- NCT07262242
- Testing
- Lidocaine (drug), Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Rhinovirus
The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study
The goal of this study is to determine the burden of Rhinoviruses (RVs) as a cause of acute, severe, respiratory illnesses leading to hospitalization.
- Trial name
- NCT07342582
- Testing
- Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Pain
VCOM Pain Free Research Collaborative
Studies estimate that 30% of people worldwide experience chronic pain. The mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue…
- Trial name
- MERCI (NCT06533345)
- Testing
- Behavior Change Coaching, Nutrition, Autonomic Recalibration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Pain
This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.
We are doing this study to find the best way to manage pain during a procedure called urethral bulking. This procedure treats urine leakage that happens with coughing, laughing, sneezing, or physical activity.
- Trial name
- NCT07889687
- Testing
- Lidocaine injection, Gyldo, Saline
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Northwell Health
Chronic Low Back Pain (Non-specific, Uncomplicated)
Evaluation of the Effectiveness and Safety of Mesotherapy in the Treatment of Chronic Low Back Pain Syndrome
The aim of this study is to evaluate the effectiveness of collagen mesotherapy in the treatment of chronic low back pain (CLBP) in the lumbosacral spine.
- Trial name
- NCT07675304
- Testing
- Tropocollagen type I, Lignocaine 1% concentration solution
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland