Clinical trials: Infliximab
Juvenile Rheumatoid Arthritis
Infliximab to Treat Children With Juvenile Rheumatoid Arthritis
This study will determine whether a stepwise increase of the drug infliximab (Remicade® (Registered Trademark)) controls juvenile rheumatoid arthritis more effectively than a fixed dose.
- Trial name
- NCT00029042
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Diabetic Retinopathy, Macular Degeneration
Intravitreal Infliximab for Diabetic Macular Edema (DME) and Choroidal Neovascularization (CNV)
Injections of medicine into the middle of the eye (intravitreal injections) are commonly used in a multitude of retinal diseases.
- Trial name
- ITVR (NCT00695682)
- Testing
- intravitreal injection of infliximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Retina Research Foundation
Ankylosing Spondylitis
Examination of Radiographic Progression, Efficacy and Safety of Long-Term Treatment With Infliximab in Patients With Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease that involves the sacroiliac joints, axial skeleton, entheses and peripheral joints.
- Trial name
- NCT00237419
- Testing
- infliximab
- Where
- 15 sites in Belgium, Finland and 4 more
- Volunteers
- 149 people
- Sponsor
- Rheumazentrum Ruhrgebiet
Obesity, Insulin Resistance
Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity
The aim of the study is to test whether neutralizing TNF-alpha with infliximab affects insulin resistance and phenotypical manifestations of the metabolic syndrome as fasting plasma insulin, total body fat, plasma lipid profile…
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00636142
- Testing
- Infliximab
- Where
- Austria
- Volunteers
- 9 people
- Sponsor
- Medical University of Graz
Rheumatoid Arthritis
Infliximab for the Treatment of Early Rheumatoid Arthritis
This study will test whether the drug combination of methotrexate and infliximab (anti-TNF-alpha antibody) is more effective than methotrexate alone for treating rheumatoid arthritis early in the disease.
- Trial name
- NCT00006292
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Endometriosis
Effect of Anti TNFa Upon Deep Endometriosis Associated Pain
Deep endometriosis associated pain is believed to be caused by inflammation. Anti TNFa has been proved to be an effective treatment for other inflammation related conditions as Crohn's disease Endometriosis is associated with an…
- Trial name
- Infliximab (NCT00604864)
- Testing
- anti TNFa monoclonal antibody - Infliximab
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Spondylarthropathies
Efficacy, Safety, and Tolerability Study of Infliximab in Juvenile Spondyloarthropathies
Tumor necrosis factor (TNF) alpha is a pro-inflammatory cytokine playing a significant role in the pathogenesis of the spondyloarthropathies (SpA).
- Trial name
- NCT00591201
- Testing
- infliximab
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- Hospital General de Mexico
Wegener's Granulomatosis, Churg-Strauss Syndrome
RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides
The purpose of this study is to compare a 2 immunosuppressant regimen for the treatment of relapsing or refractory necrotizing antineutrophil cytoplasmic antibody (ANCA) associated vasculitides.
- Conditions
- Wegener's Granulomatosis, Churg-Strauss Syndrome, Microscopic Polyangiitis
- Trial name
- NCT00307593
- Testing
- Infliximab, Rituximab
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Top Down Versus Step Up Strategies in Crohn's Disease
The study prospectively compares two treatment algorithms for newly diagnosed Crohn's disease: one 'aggressive' treatment with early introduction of immunomodulators and biologicals and one 'standard treatment' with…
- Trial name
- NCT00554710
- Testing
- infliximab+azathioprine, methylprednisolone or budesonide
- Where
- Belgium
- Volunteers
- 129 people
- Sponsor
- Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW
Rheumatoid Arthritis
A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
The purpose of the study is to compare the effects of methotrexate (MTX) alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab (IFX) on MRI-detected synovitis, bone edema and erosive changes in early…
- Trial name
- NCT00396747
- Testing
- Infliximab, methylprednisolone, methotrexate, Methotrexate, Methotrexate + Methylprednisolone
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Université Catholique de Louvain
Spondylarthropathies, Ankylosing Spondylitis
TNFalfa Blocking Treatment of Spondylarthropathies
The purpose of the study is to establish a Danish cohort of spondylarthropathy (SpA) patients who are being treated with TNFalfa blockers.
- Conditions
- Spondylarthropathies, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT00133315
- Testing
- Infliximab, Etanercept, Adalimumab
- Where
- 9 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Refractory Myositis
Treatment With TNF Blockade, Infliximab, in Patients With Myositis
This is a 4 month open trial with TNF-blockade using infliximab (an antibody that blocks TNF) in adult patients with chronic myositis (polymyositis, dermatomyositis, inclusion body myositis) who have persisting muscle weakness…
- Trial name
- NCT00443222
- Testing
- Infliximab
- Sponsor
- Karolinska Institutet
Ankylosing Spondylitis
Study of Two Schedules of Infliximab Maintenance Therapy in Ankylosing Spondylitis
Continuous treatment with the anti-tumor necrosis factor alpha monoclonal antibody infliximab is efficacious in ankylosing spondylitis (AS), whereas treatment discontinuation results in disease relapse, with variable delay.
- Trial name
- NCT00439283
- Testing
- infliximab, methotrexate
- Where
- 31 sites in France
- Volunteers
- 240 people
- Sponsor
- Association de Recherche Clinique en Rhumatologie
Reactive Arthritis
New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis
1. to investigate, whether one of the two alternative therapy strategies (antibiotic plus immunostimulation versus antibiotic plus immunosuppression) in chronic reactive arthritis is therapeutical superior to conventionel…
- Trial name
- NCT00244179
- Testing
- interferon-gamma, infliximab, dmard
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
COPD, Cachexia
Effects of Infliximab (Remicade) on Fat Free Mass in Patients With Moderate to Severe COPD Suffering From Cachexia
The purpose of this study is to determine whether infliximab is effective on fat-free mass in the treatment of patients with moderate to severe COPD suffering from cachexia.
- Trial name
- NCT00244192
- Testing
- infliximab (Remicade)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Center for Integrated Rehabilitation and Organ Failure Horn