Clinical trials: Ibuprofen
Coronavirus Infection
Role of Ibuprofen and Other Medicines on Severity of Coronavirus Disease 2019
It has been suggested that ibuprofen might be associated with more severe cases of coronavirus infections, based on the observation that severe COVID cases had been exposed to ibuprofen, resulting in a warning by the French…
- Trial name
- RISC (NCT04383899)
- Testing
- Questionnaire
- Sponsor
- University Hospital, Bordeaux
Musculoskeletal Pain
Acetaminophen (APAP) +/- Oxycodone
This is an emergency department based randomized study of oxycodone/ acetaminophen versus acetaminophen alone for patients with acute musculoskeletal pain refractory to ibuprofen
- Trial name
- NCT04122443
- Testing
- Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Montefiore Medical Center
Hip Fractures, Hip Injuries
Retrospective Evaluation of Efficacy of Meta-PENG Block
The components of the lumbar plexus and capture the articular branches of hip capsule may be effectively blocked by administering a relatively high volume of local anesthetic deep to the iliacus muscle at the level of the…
- Trial name
- NCT06721052
- Testing
- meta-Peng block, Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 7 people
- Sponsor
- Medipol University
Sunburn
Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn
A phase II multicenter, double-blinded clinical trial of the safety and efficacy of SP160412 in the temporary relief of mild to moderate, (i.e. first degree) sunburn
- Trial name
- NCT03332524
- Testing
- SP160412 Ibuprofen 400 mg and Chlorpheniramine maleate 4 mg
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- Sephoris Pharmaceuticals LLC
Depression, Myalgia
IV Ibuprofen for Post-Electroconvulsive Therapy Myalgia
Post-procedure myalgia (muscle ache) is a well-known and common complication of Electro-convulsive Treatment (ECT). Myalgias are a serious concern of patients and occur in approximately 50% of these cases.
- Trial name
- NCT01200069
- Testing
- ibuprofen intravenous
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rutgers, The State University of New Jersey
Osteoarthritis
Ibuprofen-PC Compared With Ibuprofen in a GI Safety Trial
To determine the safety and efficacy of 3 x 800 mg/day IBU-PC assessed by endoscopy and incidence of adverse events
- Trial name
- NCT00219700
- Testing
- Ibuprofen-PC
- Volunteers
- 125 people
- Sponsor
- PLx Pharma
Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis
Effect of Preoperative Oral Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Block With Supplemental Buccal and Lingual Infiltrations Using Articaine in Mandibular Molar Teeth With Irreversible Pulpitis
Effect of preoperative oral Ibuprofen on anesthetic efficacy of inferior alveolar nerve block with supplemental buccal and lingual infiltrations using articaine in mandibular molar teeth with irreversible pulpitis.
- Trial name
- NCT05927922
- Testing
- Oral Ibuprofen (Abbott, Egypt)
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Contraception
The Effect of Ibuprofen on Intrauterine Contraceptive Device Associated Uterine Bleeding
The Copper intrauterine device is the most common method of reversible contraception worldwide. Abnormal uterine bleeding and pain are the most common medical indications for the discontinuation of the intrauterine device.
- Trial name
- NCT02580344
- Testing
- Ibuprofen
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Assiut University
Malocclusion
Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic Pain
The goal of this clinical trial is to find out which method works best to reduce pain after braces are adjusted for the first time (when the first archwire is placed).
- Trial name
- NCT07638644
- Testing
- Acupressure, Ibuprofen 400 mg (if necessary), Chewing Gum
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Bahria University
Gastroduodenal Erosions
Pilot Study of OXP001(2) and Brufen in Healthy Subjects
The study will compare the study drug to an already marketed formulation of prescription strength ibuprofen (Brufen® the reference product) by looking at how the drug is taken up by the body and also by performing a specialist…
- Trial name
- NCT02521207
- Testing
- Ibuprofen
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Surgical Procedures, Operative
The Excess Opioid Disposal Study
This study is designed to test the hypothesis that providing information to patients about excess opioid disposal, calling patients prior to their outpatient post-operative surgical appointment and providing a convenient drop box…
- Trial name
- NCT03694899
- Testing
- phone contact
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Gingival Pigmentation, Depigmentation
Gingival Hyperpigmentation Treatment
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
- Conditions
- Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione
- Trial name
- NCT07595705
- Testing
- Vitamin c and glutathione, Surgical depigmentation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiovascular Diseases
Impact of Extra Virgin Olive Oil Oleocanthal Content on Platelet Reactivity
Data from limited dietary intervention trials suggest that the cardiovascular health benefit of extra virgin olive oil (EVOO) may increase with phenolic content.
- Trial name
- NCT02902913
- Testing
- D2i2, D2i0.5, D2i0
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Musculoskeletal Pain
Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg…
- Trial name
- NCT03173456
- Testing
- oxycodone/APAP, hydrocodone/APAP, codeine/APAP
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine
Pancreatic Cancer, Pain
Invasive Treatment of Pain Associated With Pancreatic Cancer on Different Levels of WHO Analgesic Ladder
Pancreatic cancer is a difficult to treat disease, mainly due to the fact that diagnosis is made usually in the late stage of this condition.
- Trial name
- NCT02424279
- Testing
- Splanchnicectomy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Gdansk
Shoulder Pain, Shoulder Injuries
Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder Surgery
Postoperative pain is a significant problem in patients undergoing arthroscopic shoulder surgery. This situation disrupts the patient's comfort and affects the functional outcome after surgery by preventing early rehabilitation.
- Trial name
- NCT06866054
- Testing
- SPSIPB block, Postoperative analgesia management
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Lateral Ankle Sprain, Ankle Injuries
PRICE vs PEACE and LOVE in Adolescent Lateral Ankle Sprain Rehabilitation
This study compared two early management strategies for adolescents with first-time lateral ankle sprain: the traditional PRICE protocol (Protection, Rest, Ice, Compression, Elevation) combined with non-steroidal…
- Conditions
- Lateral Ankle Sprain, Ankle Injuries, Sprain of Lateral Ligament, Rupture of Ligaments at Ankle and Foot Level
- Trial name
- NCT07287020
- Testing
- PRICE + NSAIDs protocol, PEACE and LOVE protocol
- Where
- Lithuania
- Volunteers
- 76 people
- Sponsor
- Lithuanian University of Health Sciences
Immune System and Related Disorders
Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation
The purpose of this clinical investigation is to evaluate the efficacy and immunologic effects of a non-pharmacological exercise intervention (push-ups) compared to an oral NSAID (ibuprofen) and an oral placebo to decrease local…
- Trial name
- NLP (NCT02807623)
- Testing
- Ibuprofen, Compound Exercise of Push-ups
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Womack Army Medical Center
Healthy Volunteers
Effect of CYP2C9*3 Polymorphism on Ibuprofen in Pakistani Population
The goal of the study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were: to evaluate the effect of this genetic polymorphism on the clinical efficacy of…
- Trial name
- NCT05983042
- Testing
- Ibuprofen 400 mg
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Riphah International University