Clinical trials: Hydroxychloroquine
Recurrent Miscarriage, First Trimester Abortion
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples. Most women have recurrent early loss with a failure of development before 10 weeks' gestation.
- Trial name
- BBQ (NCT03165136)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Glioblastoma
Phase II/III Trial of CCRT With or Without JP001 for Newly Diagnosed GBM
This is a multi-center, phase II/III, open-label, randomized, parallel and standard chemoradiation-controlled study where eligible subjects will be randomized at 1:1 ratio to receive control treatment or study treatment.
- Trial name
- NCT03008148
- Testing
- CCRT, Temozolomide, Siroquine
- Where
- 2 sites in Taiwan
- Volunteers
- 288 people
- Sponsor
- Johnpro Biotech, Inc.
Primary Sjögren's Syndrome
Hydroxychloroquine Versus Placebo in Primary Sjögren's Syndrome
Primary Sjögren's syndrome (SJp) affects 0.1% of the population. This systemic autoimmune disease systemic is characterized by disabling dryness, fatigue and pain, and systemic complications in 30% of patients.
- Trial name
- JOQUER (NCT00632866)
- Testing
- Hydroxychloroquine
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID19, Hydroxychloroquine
Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19)
This is a Italian, superiority, open label cluster-randomised, interventional clinical trial aimed at assessing whether the treatment with Hydroxychloroquine can reduce the percentage of symptomatic subjects compared to…
- Conditions
- COVID19, Hydroxychloroquine, Prophylaxis, Treatment
- Trial name
- PROTECT (NCT04363827)
- Testing
- Hydroxychloroquine
- Where
- Italy
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Pancreatic Cancer
Study of Pre-surgery Gemcitabine + Hydroxychloroquine (GcHc) in Stage IIb or III Adenocarcinoma of the Pancreas
The primary goal of the research study is to determine whether treating pancreatic cancer patients with hydroxychloroquine in combination with gemcitabine before surgery is safe.
- Trial name
- NCT01128296
- Testing
- Hydroxychloroquine, Gemcitabine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Amer Zureikat
Metastatic Colorectal Cancer
Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer
This is a two arm, 2-center, Phase II, study of 5-FU, irinotecan, bevacizumab (FOLFIRI-beva) and hydroxychloroquine (HCQ) in patients with previously untreated metastatic colorectal cancer (mCRC).
- Trial name
- NCT05843188
- Testing
- Hydroxychloroquine, Irinotecan, Leucovorin
- Where
- 2 sites in Canada
- Volunteers
- 155 people
- Sponsor
- University Health Network, Toronto
Discoid Lupus Erythematosus
A Multicentre, Randomised, Double-blind, Positive-control Clinical Trial Evaluating Dihydroartemisinin Tablets for the Treatment of Discoid Lupus Erythematosus
This study is a multicentre, randomised, double-blind, double-dummy, phase II clinical trial with a positive-control group, designed to evaluate the efficacy and safety of dihydroartemisinin tablets in the treatment of discoid…
- Trial name
- NCT07557927
- Testing
- Dihydroartemisinin tablets, Hydroxychloroquine tablets
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Kunming Pharmaceuticals, Inc.
Lupus or SLE, Interstitial Lung Disease
Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease
Recent data indicate that Telitacicept is beneficial for lupus nephritis. Our goal is to determine whether Telitacicept is an effective and safe treatment, compared to standard-of-care Cyclophosphamide, for subclinical and…
- Conditions
- Lupus or SLE, Interstitial Lung Disease, Systemic Lupus Erythematosus
- Trial name
- NCT07077486
- Testing
- Methylprednisolone (Corticosteroid), Immunosuppressant other than CYC, Telitacicept Freeze-dried powder Injection 80mg
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Influenza
The Chloroquine for Influenza Prevention Trial
A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza
- Trial name
- CHIP (NCT01078779)
- Testing
- Chloroquine
- Where
- Singapore
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Coronavirus Infection
Efficacy and Tolerability of Hydroxychloroquine in Adult Patients With COVID-19
The effective medical treatment against COVID-19 infection is still unknown. Chloroquine phosphate is a well-known antimalarial drug which has been on the market for many years.
- Trial name
- NCT04384380
- Testing
- Hydroxychloroquine Sulfate 200 MG [Plaquenil]
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Taoyuan General Hospital
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Covid19, Diarrhea
COVID-19 Disease Duration and GIT Manifestations. A New Disease Severity Classification. An Egyptian Experience
The present study conducted to correlate symptoms not only constitutional and respiratory, but GIT as a principle presentation, with laboratory markers and COVID-19 severe acute respiratory syndrome (SARS-COV2) disease outcomes…
- Trial name
- NCT04554979
- Testing
- Hydroxychloroquine Pill
- Where
- Egypt
- Volunteers
- 199 people
- Sponsor
- Cairo University
Rheumatoid Arthritis
CD40L Antagonism in Rheumatoid Arthritis (RA)
The primary objective is to determine if the addition of a 12-week course of treatment with VIB4920 to TNFi treatment will result in improved clinical disease control in patients with RA who have had an inadequate response to a…
- Trial name
- CONTROL-RA (NCT05306353)
- Testing
- VIB4920 with TNFi, VIB4920 without TNFi
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
SARS-CoV Infection
Chemoprevention Clinical Trial of COVID-19: Hydroxychloroquine Post Exposure Prophylaxis
Protocol summary Title A Prospective, randomized, adaptive phase II/III clinical trial, controlled, open-label, chemoprevention, 3-arms, parallel, multi-centred, to A Prospective, randomized, clinical trial, controlled…
- Trial name
- APCC-19 (NCT04597775)
- Testing
- hydroxychloroquine
- Volunteers
- 93 people
- Sponsor
- Regional Center for Disease Control and Prevention, Jordan
SARS-CoV-2, COVID-19
VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL)
We propose a 3-arm RCT to determine the efficacy of hydroxychloroquine or azithromycin in treating mild to moderate COVID-19 among Veterans in the outpatient setting.
- Trial name
- VA-REACH (NCT04363203)
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Salomeh Keyhani MD
Melanoma (Skin)
Hydroxychloroquine in Patients With Stage III or Stage IV Melanoma That Can Be Removed by Surgery
RATIONALE: Studying samples of blood, tumor tissue, and skin in the laboratory from patients with melanoma receiving hydroxychloroquine may help doctors understand the effect of hydroxychloroquine on biomarkers.
- Trial name
- NCT00962845
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rutgers, The State University of New Jersey
Pancreatic Cancer Resectable
Pre-Operative Trial (PGHA vs. PGH) for Resectable Pancreatic Cancer
This is a randomized phase II trial that will examine the ability of Avelumab to improve the clinical activity of a pre-operative regimen of gemcitabine, nab-paclitaxel and hydroxychloroquine in subjects with potentially…
- Trial name
- 17-134 (NCT03344172)
- Testing
- Gemcitabine, Nab-Paclitaxel, hydroxychloroquine and Avelumab, Gemcitabine, Nab-Paclitaxel, and hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Nathan Bahary, MD
Advanced Solid Tumor, Tumor Infiltrating Lymphocytes
A Clinical Study on TIL for the Treatment of Advanced Solid Tumors
This study is to investigate the safety and efficacy of tumor infiltrating lymphocyte (TIL) therapy in patients with advanced solid tumors. Autologous TILs are expanded from tumor resections or biopsies and infused i.v.
- Conditions
- Advanced Solid Tumor, Tumor Infiltrating Lymphocytes, Treatment Side Effects, Effects of Immunotherapy
- Trial name
- NCT05087745
- Testing
- Tumor Infiltrating Lymphocytes
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Juncell Therapeutics
Seronegative Spondyloarthropathies
Combination Disease-Modifying Antirheumatic Drugs (DMARDs) Versus Sulfasalazine in Inflammatory Back Pain
Till now no drug has been conclusively shown to affect the natural course of the inflammatory back ache in seronegative spondylarthropathies.
- Trial name
- NCT01040195
- Testing
- Methotrexate, Hydroxychloroquine
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast Cancer
This phase I/II trial studies the side effects and best dose of hydroxychloroquine when given together with palbociclib and letrozole before surgery in treating patients with estrogen receptor positive, HER2 negative breast…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03774472
- Testing
- Hydroxychloroquine, Letrozole, Palbociclib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center