Clinical trials: Dexmedetomidine, open to volunteers
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy
Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates
About ~3/ 1000 live-born newborns may suffer from brain injury due to a transient drop in oxygen supply to the brain during the birth process.
- Conditions
- Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
- Trial name
- COOL-SED (NCT06985290)
- Testing
- Dexmedetomidine Infusion, Morphine Infusion
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ipsita Goswami
Pain, Pain Management Following Cardiopulmonary Bypass Surgery
Addition of Dexmedetomidine to Ropivacaine in Bilateral Erector Spinae Plane Block in Patients Undergoing Coronary Artery Bypass Surgery
Coronary artery bypass surgery (CABG), typically performed through a median sternotomy, causes significant postoperative pain. Managing this pain effectively while reducing reliance on opioids is essential, as opioids can lead to…
- Conditions
- Pain, Pain Management Following Cardiopulmonary Bypass Surgery, Erector Spinae Plane Block
- Trial name
- NCT06981949
- Testing
- Dexmedetomidine, Ropivacaine
- Volunteers
- 110 people
- Sponsor
- Lebanese American University
Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY
Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries
The study aims to compare the efficacy, safety and overall effectiveness of dexmedetomidine and dexmedtomidine and ketamine (ketodex) in achieving controlled hypotension during Ear and nose surgeries.
- Trial name
- NCT06981494
- Testing
- Dexmedetomidine, Dexmedetomidine and ketamine ( Ketodex )
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Herpes Zoster (HZ)
Clinical Study on the Treatment of Herpes Zoster Pain With Dexmedetomidine Combined With Long-term High Voltage
Participants will be invited to take part in clinical research. This informed consent form will provide information to the participants to help them decide whether to participate in the clinical study.
- Trial name
- NCT06978192
- Testing
- dexmedetomidine nasal spray group, long duration high voltage pulse RF therapy group
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Fenghui Deng
Laparoscopic Sleeve Gastrectomy
Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in Combination With Paragastric Neural Block
The goal of this clinical trial is to learn which is better, combining Dexmedetomidine infusion and paragastric neural block or combining laparoscopic TAP block and paragastric neural block to enhance recovery after laparoscopic…
- Trial name
- NCT06970626
- Testing
- Dexmedetomidine infusion, Paragastric neural block, Laparoscopic Transversus Abdominis Plane (LTAP) block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Laparoscopic Sleeve Gastrectomy (LSG)
Combining Dexmedetomidine Infusion and Paragastric Autonomic Neural Block to Enhance Postoperative Recovery in Patients Undergoing Laparoscopic Sleeve Gastrectomy
The goal of this clinical trial is to learn if combining Dexmedetomidine infusion and paragastric autonomic neural block will enhance the postoperative recovery of patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- NCT06970678
- Testing
- Dexmedetomidine infusion, paragastric autonomic neural block
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Alexandria University
Delirium - Postoperative, Opioid-Free Anaesthesia
Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery
Background Postoperative delirium (POD) is a common acute and transient form of brain dysfunction in elderly patients following surgery that can lead to serious adverse clinical outcomes and even death.
- Trial name
- NCT06958393
- Testing
- Dexmedetomidine, Esketamine, Esmolol
- Where
- China
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Laceration of Skin, Distress, Emotional
Anxiolysis for Laceration Repair in Children
This is a 3-arm adaptive clinical trial to the optimal light sedative for reducing distress during laceration repair in children.
- Trial name
- ALICE (NCT05383495)
- Testing
- Dexmedetomidine, Midazolam Nasal Spray, Nitrous oxide
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dexmedetomidine, Lidocaine
Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat
Objective: The present study was to investigate the effect of intravenous lidocaine combined with intratracheal dexmedetomidine on postoperative sore throat in patients undergoing thyroid cancer surgery.
- Conditions
- Dexmedetomidine, Lidocaine, Sore Throat
- Trial name
- NCT06952309
- Testing
- Intracheal dexmedetomidine, Intravenous lidocaine, Intravenous lidocaine combined with intracheal dexmedetomidine
- Volunteers
- 144 people
- Sponsor
- Anqing Municipal Hospital
Modified Radical Mastectomy, Breast Cancer
Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy
The goal of this clinical trial is to compare Ultrasound Guided Erector Spinae and Ultrasound Guided Serratus Anterior Plane Block post Modified Radical Mastectomy in adult females.
- Trial name
- FMASUMD66/2025 (NCT06947330)
- Testing
- Unilateral Erector Spinae group, Unilateral Serratus Anterior group
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kholoud Usama
Post Spinal Anesthesia Shivering
Intrathecal DEX With Bupivacaine Inpost-spinal Shivering After CS.
This prospective, randomized, double-blind, placebo-controlled study to determine whether intrathecal dexmedetomidine, administered along with hyperbaric bupivacaine for covering Cesarean delivery decreases the incidence of…
- Trial name
- DEX (NCT06942000)
- Testing
- dexmedetomidine 3mcg group, dexmedetomidine 5mcg, preservative-free 0.9% saline.
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Post Operative Analgesia
Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery
The aim of this study to compare the analgesic effects of intraarticular dexmedetomidine added to bupivacaine with those of bupivacaine alone after knee arthroscopy
- Trial name
- DEXMED (NCT06665438)
- Testing
- Bupivacaine 0.25%, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Tracheal Intubation Morbidity, Laryngoscopy
Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients
The aim of this study is to compare the efficacy of oral melatonin versus nebulized dexmedetomidine in attenuating the hemodynamic response to direct laryngoscopy and endotracheal intubation in controlled hypertensive patients…
- Conditions
- Tracheal Intubation Morbidity, Laryngoscopy, Hemodynamic Response
- Trial name
- NCT06935292
- Testing
- Dexmedetomidine, Melatonin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Pain Management, Noncardiac Surgery
Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain
Background:Preemptive analgesia is the initiation of analgesic regimen before the onset of nociceptive stimulation, preventing the amplification of pain due to peripheral and central sensitization and thereby reducing subsequent…
- Trial name
- NCT06671327
- Testing
- Preemptive Dexmedetomidine injection, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 208 people
- Sponsor
- China International Neuroscience Institution
Dexmedetomidine, Lidocaine
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy
This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.
- Conditions
- Dexmedetomidine, Lidocaine, Infusion, Adjuvants
- Trial name
- NCT06910644
- Testing
- Dexmedetomidine, Lidocaine, Isotonic saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Pain Management
Dexmedetomidine in Sonographic Guided Erector Spinae Plane Block
to investigate the postoperative analgesic effect of dexmedetomidine addition with different doses as an adjuvant to bupivacaine to Erector spinae plane block after renal surgeries.
- Trial name
- NCT06899841
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Preoperative Anxiety, Emergence Agitation
Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation, Intraoperative Brain Electrical Activity, and Incidence of Agitation During Recovery in Children
Pre - operative anxiety and emergence agitation are common issues among pediatric patients, which have various influences on the recovery progress and prognosis of children.
- Trial name
- NCT06896721
- Testing
- Preoperative sedation with dexmedetomidine was administered nasal before surgery, Preoperative sedation with normal saline was administered nasal before surgery
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Fuzhou Hua
Postoperative Pain
Dexmedetomidine Wound Infiltration in Cesarean Section
The effects of four different wound infiltration protocols in cesarean section will be investigated on parturient' pain intensity, PCA morphine consumption given, side effects and parturient' overall satisfaction.
- Trial name
- NCT03382938
- Testing
- Dexmedetomidine, Ropivacaine, Dexmedetomidine - Ropivacaine
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital