Clinical trials: Dexamethasone
Coronary Artery Disease, Aortic Valve Disease
Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) is associated with a significant risk of mortality.
- Trial name
- GLORIOUS-II (NCT05635227)
- Testing
- Dexamethasone phosphate, Isotonic sodium chloride (0.9%), Olanzapine 10 MG
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, Neuroinflammatory Response
Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia
The goal of this clinical trial is to investigate the immunomodulatory effects of the drugs dexamethasone, tocilizumab and anakinra in healthy male subjects aged 18 to 35 undergoing experimental endotoxemia.
- Conditions
- Sepsis, Neuroinflammatory Response, Immunosuppresion, Endotoxemia
- Trial name
- DEDICATE-LPS (NCT06624436)
- Testing
- Dexamethasone, Tocilizumab, Anakinra
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Multiple Myeloma
Ixazomib Plus Lenalidomide Plus Dexamethasone for Newly Diagnosed Myeloma Patients
This study will evaluate the efficacy and safety of 3-drug all-oral combination, ixazomib plus lenalidomide plus dexamethasone (IRd) as induction treatment for autologous stem cell transplantation eligible patients followed by…
- Trial name
- NCT03376672
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 26 sites in Finland, Lithuania and 2 more
- Volunteers
- 120 people
- Sponsor
- Raija Silvennoinen
Relapsed/Refractory Multiple Myeloma
Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma
Evaluate the efficacy and safety of Belantamab Mafodotin, cyclophosphamide, and dexamethasone in patients with Relapsed/Refractory Multiple Myeloma
- Trial name
- NCT04896658
- Testing
- Belantamab Mafodotin, Cyclophosphamide and Dexamethasone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Acute Graft Versus Host Disease
Efficacy of Human Chorionic Gonadotropin in Acute GVHD Treatment
Graft-versus-host disease is a complication of allogeneic hematopoietic cell transplantation with high morbidity and mortality. The standard treatment is corticosteroids, and based on the response within 3 to 7 days, a…
- Trial name
- NCT06904599
- Testing
- Human chorionic gonadotropin (hCG), Prednisone, Dexamethasone
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Metastatic Non-squamous Non Small Cell Lung Cancer
Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab in First Line Metastatic Non-squamous NSCLC
This is an efficacy and safety study of cosibelimab (CK-301) combined with pemetrexed/platinum chemotherapy versus pemetrexed/platinum chemotherapy alone in participants with advanced or metastatic non-squamous non-small cell…
- Trial name
- CONTERNO (NCT04786964)
- Testing
- Cosibelimab, Cisplatin, Carboplatin
- Where
- 22 sites in Brazil, Georgia and 6 more
- Volunteers
- 25 people
- Sponsor
- Checkpoint Therapeutics, Inc.
Bowel Disease
Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy
This study will be a single center, prospective triple blinded randomized controlled study, comparing the use of liposomal bupivacaine (Exparel) to regular bupivacaine with adjuncts in bilateral mid-abdominal transverse abdominis…
- Trial name
- TAPLIP (NCT05224089)
- Testing
- Liposomal Bupivicaine/Bupivacaine Admixture, Bupivacaine HCL
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Hartford Hospital
Plantar Fasciitis
The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis
This single-blinded, randomized-controlled trial compares the efficacy of ultrasound-guided onabotulinumtoxinA (BTX-A) injections to the flexor digitorum brevis with current standard of care corticosteroid injections to the…
- Trial name
- NCT05367271
- Testing
- Botulinum Toxin A, Dexamethasone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Western Institute for Veterans Research
Neurocysticercosis
Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)
Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis
- Trial name
- NCT02945527
- Testing
- Acetazolamide, Dexamethasone
- Where
- Peru
- Volunteers
- 4 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Relapse Multiple Myeloma
Melflufen for Elderly Patients With Relapsed Myeloma
This is a pilot study aimed to evaluate the efficacy and tolerability of melflufen plus dexamethasone in elderly patients at second relapse. Thirty elderly patients at second or subsequent relapse.
- Trial name
- NCT06682637
- Testing
- Melflufen, Dexamethasone
- Where
- 10 sites in Italy
- Sponsor
- Fondazione EMN Italy Onlus
Multiple Myeloma
Daratumumab Retreatment in Participants With Multiple Myeloma Who Have Been Previously Treated With Daratumumab
The purpose of this study is to compare the efficacy (rate of very good partial response [VGPR] or better as best response as defined by the International Myeloma Working Group [IMWG] criteria) of daratumumab subcutaneous…
- Trial name
- NCT03871829
- Testing
- Carfilzomib 20 mg/m^2, Carfilzomib 70 mg/m^2, Dexamethasone 40 mg
- Where
- 108 sites in United States, Belgium and 11 more
- Volunteers
- 88 people
- Sponsor
- Janssen Research & Development, LLC
Leptomeningeal Metastasis
A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases
The goal of this clinical trial is to learn if the intraventricular injection of Pemetrexed and Nivolumab works to treat refractory non-squamous non-small cell lung cancer with leptomeningeal metastases.
- Trial name
- NCT06901817
- Testing
- Intraventricular Pemetrexed, Intraventricular Nivolumab, Intraventricular Dexamethasone
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Shanghai Cancer Hospital, China
Multiple Myeloma
Treatment of Relapsed/Refractory Multiple Myeloma (rrMM) With Pomalidomide in Clinical Practice
There is a high unmet medical need for an anti-myeloma therapy for RRMM patients previously treated with Lenalidomide and Bortezomib, due to poor prognosis.
- Trial name
- NCT02555839
- Testing
- Pomalidomide, Dexamethasone, Bortezomib
- Where
- 13 sites in Austria
- Volunteers
- 127 people
- Sponsor
- Celgene
Multiple Myeloma
Iberdomide Combined With Low-dose Cyclophosphamide and Dexamethasone
Evaluation of the effect iberdomide combined with low-dose cyclophosphamide and dexamethasone in patients with relapsed/refractory multiple myeloma.
- Trial name
- ICON (NCT04392037)
- Testing
- Iberdomide plus low-dose cyclophosphamide and dexamethasone
- Where
- 9 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Colorectal Cancer, Metastatic Cancer
Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer
The purpose of this study is to find the highest dose that can be given safely to people who have had liver disease resected. This is a Phase I study.
- Trial name
- NCT00059930
- Testing
- FOLFOX regimen, dexamethasone, floxuridine
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Carbon Monoxide Poisoning, Delayed Neurocognitive Sequelae
The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury.
- Trial name
- NCT06811675
- Testing
- Dexamethasone and N-acetylcysteine (NAC)
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- China Medical University Hospital
Post Operative Pain Control, Endodontic Treatment
Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic…
- Trial name
- NCT06894069
- Testing
- Dexamethasone
- Volunteers
- 80 people
- Sponsor
- University of Jordan
Hip Osteoarthritis, Hip Arthropathy
Dexamethasone for PENG Block in Total Hip Arthroplasty
Effect of adding Dexamethasone to Periarticular Nerve Group Block in Patients undergoing Total Hip Arthroplasty
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Hip Pain Chronic
- Trial name
- NCT06470139
- Testing
- Ropivacaine 0.2% Injectable Solution, Ropivacaine 0.2% Injectable Solution + 4mg Dexamethasone
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Opioid Use, Pain, Acute
TAP Block Using Liposomal Bupivacaine for Post-cesarean Delivery Analgesia- Walking Towards Recovery
The TAP block offers analgesia by blocking the sensory nerves of the anterior abdominal wall. The procedure is performed under ultrasound guidance, after identification of the external oblique, internal oblique and transverse…
- Trial name
- NCT04393207
- Testing
- Liposomal bupivacaine (LB), Dexamethasone and methylprednisolone (CG), Control group (Bupivacaine)- (BPG)
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Yale University