Clinical trials: Dexamethasone
Cancer, Metastasis
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
To determine the safety and efficacy of using the drug azeliragon combined with stereotactic radiosurgery. Specifically, to determine if this combination will lead to improved response in the brain (tumor shrinking in size) and…
- Conditions
- Cancer, Metastasis, Metastatic Cancer, Brain Metastases
- Trial name
- ADORATION (NCT05789589)
- Testing
- Azeliragon, Stereotactic radiosurgery, Corticosteroid
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Baptist Health South Florida
Multiple Myeloma in Relapse
Clinical Trial of Clarithromycin, Lenalidomide and Dexamethasone in the Treatment of the First Relapsed Multiple Myeloma
BiRd regimen consisting of clarithromycin and Rd is safe and effective in NDMM. It can significantly increase ORR (up to 90.3%) , relief depth (≥VGPR), and prolong PFS to 43 months.
- Trial name
- NCT04063189
- Testing
- Clarithromycin Lenalidomide Dexamethasone (BiRd) Regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Jilin University
Hoarseness, Post Operative Complicaiton
Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery
The goal of this clinical trial is to evaluate whether intraoperative spraying of dexamethasone onto the abdominal vagal nerve-rich areas can prevent postoperative hoarseness in patients undergoing elective upper abdominal…
- Trial name
- NCT07722091
- Testing
- Dexamethasone, Saline (0.9% NaCl)
- Where
- 4 sites in China
- Volunteers
- 584 people
- Sponsor
- Fujian Medical University Union Hospital
Implant Stability and Osseointegration
Topical Dexamethasone, Ascorbic Acid, and BGP for Enhancing Implant Osseointegration
The goal of this clinical trial was to evaluate whether the topical application of a combination of dexamethasone, ascorbic acid, and β-sodium glycerophosphate could enhance implant osseointegration in adult dental implant…
- Trial name
- DAG (NCT07060859)
- Testing
- Topical Application of Dexamethasone, Ascorbic Acid, and β-Sodium Glycerophosphate
- Where
- Palestinian Territories
- Volunteers
- 18 people
- Sponsor
- Manar Ziad Foura-Matar
Recurrent Plasma Cell Myeloma
Pembrolizumab, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
This phase II trial studies how well pembrolizumab works when given together with ixazomib citrate and dexamethasone in treating patients with multiple myeloma that has come back (relapsed).
- Trial name
- NCT03506360
- Testing
- Dexamethasone, Ixazomib Citrate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Breast Cancer
RCT Comparing ESPB Solutions in Breast Surgery
The object of our research is to investigate the relative efficacy of liposomal bupivacaine administered via an Erector Spinae Plane (ESP) block as compared to our standard of care medication solution of (bupivacaine mixed with…
- Trial name
- NCT04603911
- Testing
- Liposomal bupivacaine, Bupivacaine, epinephrine, dexamethasone, and clonidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Tufts Medical Center
Airway Obstruction
Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults
The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume…
- Trial name
- NCT00548483
- Testing
- dexamethasone (Oradexon, Nederland)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Mackay Memorial Hospital
Quality of Life, Pelvic Organ Prolapse
Does Dexamethasone Administration Improve Recovery In Patients Undergoing Minimally Invasive Sacrocolpopexy?
The primary aim is to evaluate whether standard administration of Dexamethasone at the time of general anesthesia induction at the time of minimally invasive sacrocolpopexy (MISC) would result in improved quality of recovery…
- Conditions
- Quality of Life, Pelvic Organ Prolapse, Prolapses, Vaginal Vault
- Trial name
- NCT03094442
- Testing
- Dexamethasone, Normal saline
- Where
- United States
- Sponsor
- The Cleveland Clinic
Nausea, Vomiting
A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy.
- Conditions
- Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms
- Trial name
- NCT07169851
- Testing
- LY3537021, Standard of Care Antiemetic Therapies, Background Chemotherapy
- Where
- 67 sites in United States, Australia and 8 more
- Volunteers
- 204 people
- Sponsor
- Eli Lilly and Company
Myeloma
Pomalidomide With Melphalan and Dexamethasone for Untreated Systemic AL Amyloidosis
The goal of this clinical research study is to find the highest tolerable dose of pomalidomide that can be given in combination with melphalan and dexamethasone that can be given to patients with AL amyloidosis.
- Trial name
- NCT01807286
- Testing
- Pomalidomide, Melphalan, Dexamethasone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Croup
Croup Dosing Study
Croup is a common childhood respiratory disease that often leads to frequent emergency department visits. It is a viral infection that causes cough, throat, and airway swelling, making breathing difficult.
- Trial name
- NCT06272383
- Testing
- 0.15 mg/kg dexamethasone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Multiple Myeloma
Lenalidomide Intensification in Patients With Serologic/Asymptomatic Progression of Multiple Myeloma While on Lenalidomide Maintenance
The purpose of this study is to determine whether this disease will get better if treated with higher doses of Lenalidomide even if the disease returns while taking low doses of Lenalidomide.
- Trial name
- NCT01463670
- Testing
- lenalidomide
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Myeloma
MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma
The purpose of this study is to determine the Recommended Phase 2 Dose and clinical benefit of elranatamab in combination with other anti-cancer therapies in participants with multiple myeloma.
- Trial name
- NCT05090566
- Testing
- Elranatamab + Nirogacestat, Elranatamab + lenalidomide + dexamethasone
- Where
- 25 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Pfizer
Retinal Vein Occlusion, Macular Edema
Safety and Efficacy Study of Ozurdex® Compared to Lucentis® in Patients With Branch Retinal Vein Occlusion
This study will evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex®) compared to ranibizumab (Lucentis®) in patients with branch retinal vein occlusion (BRVO).
- Trial name
- NCT01427751
- Testing
- dexamethasone intravitreal implant, ranibizumab
- Where
- 6 sites in France, Germany and 4 more
- Volunteers
- 307 people
- Sponsor
- Allergan
Sensorineural Hearing Loss, Bilateral Hearing Loss
Cochlear Implant With Dexamethasone Eluting Electrode Array
An evaluation of Cochlear's cochlear implant electrode array which passively elutes dexamethasone for a defined period of time to help reduce inflammatory responses.
- Trial name
- NCT04750642
- Testing
- CI632D, CI632
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 42 people
- Sponsor
- Cochlear
Bronchiolitis
Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study
We hypothesize that infants with bronchiolitis treated with inhaled epinephrine in the Emergency Department (ED) and a 2-day course of oral dexamethasone will have fewer hospitalizations over 7 days compared to infants treated…
- Trial name
- BIPED (NCT03567473)
- Testing
- Oral dexamethasone, Nebulized Epinephrine, Nebulized normal saline
- Where
- 12 sites in Australia, Canada and 1 more
- Volunteers
- 864 people
- Sponsor
- Children's Hospital of Eastern Ontario
Refractory Multiple Myeloma
Bortezomib, Liposomal Doxorubicin Hydrochloride, Dexamethasone, and Cyclophosphamide in Treating Patients With Multiple Myeloma That Relapsed After Autologous Stem Cell Transplant
This phase II trial is studying how well giving bortezomib together with liposomal doxorubicin hydrochloride, dexamethasone, and cyclophosphamide works in treating patients with multiple myeloma that relapsed after autologous…
- Trial name
- NCT01078441
- Testing
- liposomal doxorubicin, bortezomib, dexamethasone
- Where
- 130 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Third Molar Surgery
Intraosseous Versus Submucosal Dexamethsone Injection in Third Molar Surgery
The goal of this clinical trial is to learn if intraosseous dexamethasone injection is better for pain and swelling postop 3rd molar surgery than submucosal dexamethasone injection.
- Trial name
- NCT06720051
- Testing
- Intraosseous dexamethasone injection after 3rd molar surgery, Submucosal dexamethasone injection after 3rd molar surgery
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Postoperative Nausea and Vomiting
Prevention of Nausea and Vomiting in Patients After Surgery
Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. The incidence can be as high as 80 percent in high-risk patients.
- Trial name
- NCT02021851
- Testing
- Dexamethasone and aprepitant, Dexamethasone and ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Yeditepe University Hospital
Lymphoma, Follicular
Bortezomib (Velcade) With Standard Chemotherapy for Relapsed or Refractory Follicular Lymphoma
The purpose of this study is to evaluate the effectiveness and safety of combining bortezomib (Velcade) with rituximab, fludarabine, mitoxantrone, and dexamethasone in treating patients with follicular cell lymphoma.
- Trial name
- NCT00510887
- Testing
- Bortezomib, Rituximab, Fludarabine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University