Clinical trials: Best Practice
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer
This clinical trial compares the use of a shared decision-making communication tool during a clinical encounter to standard care for improving the quality of the shared decision-making process among patients with non-small cell…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06122064
- Testing
- Best Practice, Communication Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Voice Disorders, Muscle Tension Dysphonia
RCT Face-to-face Group Voice Therapy vs Telepractice Group Voice Therapy for Muscle Tension Dysphonia
The goal of this clinical trial is to compare face-to-face group voice therapy to telepractice group voice therapy for muscle tension dysphonia (MTD).
- Conditions
- Voice Disorders, Muscle Tension Dysphonia, Aphonia
- Trial name
- NCT06524193
- Testing
- Telepractice group voice therapy, Face-to-face group voice therapy
- Where
- Hong Kong
- Volunteers
- 168 people
- Sponsor
- Chinese University of Hong Kong
Ischemic Stroke
Normobaric Oxygen in AIS Transferred for EVT
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic stroke
- Trial name
- AN-O2 (NCT06666764)
- Testing
- NBO, Control
- Where
- 112 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Capital Medical University
Advanced Breast Adenocarcinoma, Advanced HER2-Negative Breast Carcinoma
Effects of Ribociclib and Palbociclib on Tumor and Blood Characteristics in Patients With Metastatic Breast Cancer
This clinical trial attempts to understand the differences between two chemotherapy drugs, ribociclib and palbociclib, and how they fight cancer.
- Conditions
- Advanced Breast Adenocarcinoma, Advanced HER2-Negative Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
- Trial name
- NCT05244434
- Testing
- Best Practice, Biopsy, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Low-Birth-Weight Infant, Premature Infants
Analyzer of Human Milk: Applicability in Clinical Practice in Order to Achieve the Best Nutrition for Infants
An observational and prospective study involving about 30 healthy lactating mothers whose preterm infant(s) is/are hospitalized at Neonatal Intensive Care Unit after childbirth and who can provide enough maternal milk (3mL) to be…
- Trial name
- MISTU (NCT02971904)
- Testing
- human milk collection
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danone Early Life Nutrition Brazil
Obesity
WOOP VA: Promoting Weight Management in Primary Care
Approximately 40% of Veterans have obesity and are at increased risk for cardiometabolic disease. Intensive lifestyle-based weight management programs can lead to clinically significant ( 5%) weight loss.
- Trial name
- WOOP VA (NCT05014984)
- Testing
- mental contrasting with implementation intentions, telephone-delivered, telehealth-delivered, and or in-person MOVE! or TeleMOVE!, Information About Diet, Physical Activity, and Weight Management (Baseline Visit - 10 minutes): All
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Central Nervous System Infections
Effect of a Bundle of Interventions on the Outcomes of Patients With Intracranial Devices (ICP Monitor e EVD)
Non-randomized clinical trial conducted in the adult ICUs of Brazilian hospitals participating in the IMPACTO MR Platform, involving adult patients using an intracranial pressure monitoring catheter device or external ventricular…
- Trial name
- NCT06412549
- Testing
- Health care practices and routines
- Volunteers
- 1,300 people
- Sponsor
- Beneficência Portuguesa de São Paulo
Medication Adherence
Development and Evaluation of an Electronic Health Record-based Medication Complete Communication (EMC2) Strategy
There is a well-documented need for effective interventions that can help patients understand and safely adhere to prescribed medications, particularly those with greater potential for harm if not taken correctly.
- Trial name
- NCT03652272
- Testing
- EMC2
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Kidney Transplant, Patient Education
A Randomized Controlled Trial of a Pre-Transplant Education Intervention
A multi-center, randomized, controlled clinical trial will be conducted to test the effectiveness of a home-based video intervention on improving kidney transplant candidate's knowledge, self-efficacy, quality of life, beliefs in…
- Conditions
- Kidney Transplant, Patient Education, Quality of Life
- Trial name
- NCT03633136
- Testing
- electronic video education
- Where
- 3 sites in Canada
- Volunteers
- 162 people
- Sponsor
- University of Saskatchewan
Difficult Airway
Thyromental Height Test Versus Sternomental Displacement in Elderly
The study is designed to evaluate the validity of the SMDD as a predictor of difficult airway in elderly and to compare its validity with that of the TMHT.
- Trial name
- NCT05414214
- Testing
- Thyromental Height Test, Sternomental displacement, General anesthesia
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Heart Failure With Preserved Ejection Fraction (HFPEF), Coronary Artery Disease
Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
HFpEF (heart failure with preserved ejection fraction) is a condition in which the heart muscle becomes stiff and can't pump blood properly.
- Trial name
- REPRIEVED (NCT07560436)
- Testing
- Percutaneous coronary intervention
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- King's College London
Depression
Cluster Randomized Trial of Knowledge Brokering to Integrate Mood and Smoking Cessation in Ontario Primary Care
Compared to smokers who are not depressed, smokers with depression who try to quit smoking are 10% less likely to succeed when given standard treatment.
- Trial name
- NCT03130998
- Testing
- Remote Knowledge Broker (rKB), Emails
- Where
- Canada
- Volunteers
- 2,765 people
- Sponsor
- Centre for Addiction and Mental Health
Hiv, Insomnia
HIV-related Insomnia and Inflammation
This randomized trial will determine the effects of internet cognitive behavioral therapy on measures of systemic inflammation in HIV-positive people receiving antiretroviral therapy.
- Trial name
- NCT04721067
- Testing
- SHUTi, Sleep Education/Hygiene
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Osteoarthritis, Knee
Boosting Exercise Adherence in Knee Osteoarthritis
This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise among Veterans receiving physical therapy (PT) for…
- Trial name
- BOOST-OA (NCT07219732)
- Testing
- Usual PT Care (UC), BOOST-OA
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Healthy, Exercise
Digital Mindset Intervention for Half Marathon Performance
The goal of this randomized controlled trial is to test whether a brief digital mindset training program can improve performance among recreational runners training for a half marathon in New Zealand in 2025.
- Conditions
- Healthy, Exercise, Psychological Intervention
- Trial name
- NCT06972121
- Testing
- Mindset Intervention, Marathon Performance Training
- Where
- New Zealand
- Volunteers
- 207 people
- Sponsor
- University of Auckland, New Zealand
Acute Lymphoblastic Leukemia
MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence
This clinical trial identifies and addresses barriers to pediatric medication adherence among families of children with acute lymphoblastic leukemia.
- Trial name
- NCT06323044
- Testing
- Best Practice, Biospecimen Collection, Electronic Health Record Review
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Communication
A Communication Tool to Assist Severely Injured Older Adults
The purpose of this study is to test the effect of the "Best Case/Worse Case" (BC/WC) communication tool on the quality of communication with older patients admitted to two trauma units.
- Trial name
- NCT03188055
- Testing
- Best Case/Worst Case communication tool
- Where
- 2 sites in United States
- Volunteers
- 298 people
- Sponsor
- University of Wisconsin, Madison
Non-Muscle Invasive Bladder Carcinoma
Home-Based Outpatient Model for BCG Delivery to Reduce Undue Burden on Patients Undergoing Treatment for Non-Muscle Invasive Bladder Carcinoma
This phase I/II trial tests the feasibility of home based BCG delivery to reduce undue burden on patients undergoing treatment for non-muscle invasive bladder carcinoma.
- Trial name
- NCT07874347
- Testing
- BCG Solution, Best Practice, Cystoscopy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cervical Carcinoma, Human Papillomavirus-Related Malignant Neoplasm
I Vaccinate: Testing Multi-Level Interventions to Improve HPV Vaccination
This trial studies how well a multi-level health system-based intervention works in improving human papillomavirus (HPV) vaccine initiation and completion among children in health systems in four Appalachian states.
- Trial name
- IVaccinate (NCT04452526)
- Testing
- Best Practice, Educational Intervention, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Alzheimer Disease, At Risk, Alzheimer Disease, Protection Against
The STEP 4Life Trial
The objective of this study is to test the feasibility of using behavioral economic interventions (gamification with social incentives) targeting daily step counts to prevent or delay the development of Alzheimer's Disease and…
- Conditions
- Alzheimer Disease, At Risk, Alzheimer Disease, Protection Against, Dementia
- Trial name
- NCT05069155
- Testing
- Gamification
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pennsylvania